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Increased frequency of blaNDM in a tertiary care hospital in southern Brazil

  • Clinical Microbiology – Short Communication
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Abstract

Resistance to carbapenems due to metallo-beta-lactamase NDM-1 was first described in Brazil in 2013. To date, only a few scattered reports of the prevalence of NDM-1 in the country have been reported, and most of them indicated a very low prevalence of this metalloenzyme. In the present study, we report a steady increase in the frequency of NDM among Enterobacterales resistant to carbapenems in a tertiary care hospital in southern Brazil. Carbapenemase genes were evaluated by multiplex real-time polymerase chain using high-resolution melting analysis among 3501 isolates of 8 different species of Enterobacterales recovered from January 2015 to May 2020. The blaKPC-like was identified in 3003 isolates (85.8%) and the blaNDM-like was the second most common gene (351 isolates—10%). There was a steady increase in frequency of blaNDM-like, from 4.2% in 2015 to 24% in 2020. The increase of blaNDM frequency raises an important matter as novel therapeutic options are currently very limited for the treatment of patients infected by bacteria carrying the blaNDM.

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Funding

This work has been funded by INPRA - Instituto Nacional de Pesquisa em Resistência Antimicrobiana - Brazil (INCT/CNPq: 465718/2014-0 and INCT/FAPERGS: 17/2551-0000514-7) and by Fundo de Incentivo a Pesquisa e Eventos do Hospital de Clínicas de Porto Alegre (FIPE/HCPA) (Project no. 19-0203).

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Authors and Affiliations

  1. LABRESIS - Laboratório de Pesquisa em Resistência Bacteriana, Centro de Pesquisa Experimental, Hospital de Clínicas de Porto Alegre (HCPA), Rua Ramiro Barcelos 2350, Porto Alegre, RS, 90.035-903, Brazil

    Priscila Lamb Wink, Amanda Silva Martins, Fabiana Volpato, Alexandre P. Zavascki & Afonso L. Barth

  2. Programa de Pós-Graduação em Ciências Farmacêuticas (PPGCF), Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil

    Priscila Lamb Wink & Afonso L. Barth

  3. Programa de Pós-Graduação em Ciências Médicas (PPGCM), Faculdade de Medicina, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil

    Fabiana Volpato & Afonso L. Barth

  4. Infectious Diseases Service, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil

    Alexandre P. Zavascki

  5. Department of Internal Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil

    Alexandre P. Zavascki

Authors
  1. Priscila Lamb Wink
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  2. Amanda Silva Martins
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  3. Fabiana Volpato
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  4. Alexandre P. Zavascki
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  5. Afonso L. Barth
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Corresponding author

Correspondence to Priscila Lamb Wink.

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Conflict of interest

APZ received a research grant from Pfizer.

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Responsible Editor: Jorge Luiz Mello Sampaio

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Wink, P.L., Martins, A.S., Volpato, F. et al. Increased frequency of blaNDM in a tertiary care hospital in southern Brazil. Braz J Microbiol 52, 299–301 (2021). https://doi.org/10.1007/s42770-020-00412-z

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  • DOI: https://doi.org/10.1007/s42770-020-00412-z

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