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Multi-Functional Fibrous Dressings for Burn Injury Treatment with Pain and Swelling Relief and Scarless Wound Healing

Advanced Fiber Materials volume 5, pages 1963–1985 (2023)Cite this article

Abstract

As one of the most common forms of skin injuries, skin burns are often accompanied by edema pain, suppuration of infection, slow tissue regeneration, and severe scar formation, which significantly delay wound healing as well as affect the quality of life. We prepared multifunctional electrospun poly(L-lactide-co-glycolide)/gelatin (P/G)-based dressings to synergistically harness the therapeutic benefits of peppermint essential oil (T), burn ointment (B), and Oregano essential oil (O) (P/G@TBO) for skin regeneration in punch and burn injury models. The P/G@TBO can afford the sustained release of bioactive cues for up to 72 h as well as remarkably promote cell migration (ca. P/G@TBO, 89% vs. control group, 51%) at 24 h. The P/G@TBO membranes also showed significant angiogenic effect as well as antibacterial and anti-inflammatory properties than that of the control group in vitro. Moreover, P/G@TBO dressings enabled fast wound healing (ca. P/G@TBO, 100% wound closure vs. control group, 95%) in a full-thickness excisional defect model up to 14 days in rats. Further evaluation of membranes in different animal models, including tail wagging model, facial itch model, and hot burn injury model showed significant pain relieve effect as well as itching and swelling relief functions during earlier stages of wound healing. Membranes were next transplanted into a scalded wound model in rats and an ear punch wound model in rabbits, which manifested antibacterial and anti-inflammatory properties and promoted re-epithelialization to achieve scarless wound healing percentage wound closure at day 28: P/G@TBO, 96% vs. control group 66%. Taken together our approach of simultaneously harnessing T, B, and O to enable multifunctionality to fibrous dressings may hold great promise for burn wound healing applications and other related disciplines.

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Data availability

The extended data will be available upon request.

Abbreviations

P/G:

Poly(L-lactide-co-glycolide)/gelatin

HUVECs:

Human umbilical vein endothelial cells

Gel:

Gelatin

ROS:

Reactive oxygen species

P:

Peppermint essential oil

ECM:

Extracellular matrix

B:

Burn ointment

E. coli:

Escherichia coli

O:

Oregano essential oil

S. aureus:

Staphylococcus aureus

FBS:

Fetal bovine serum

3D:

Three-dimensional

TE:

Tissue engineering

DMEM:

Dulbecco's Modified Eagle Medium

Rpm:

Rotations per minute

V c :

Vitamin C

SEM:

Scanning electron microscopy

OD:

Optical density

DI:

Deionized

RBCs:

Red blood cells

DPPH:

2,2-Diphenyl-1-picrylhydrazyl

PBS:

Phosphate-buffered saline

WCA:

Water contact angle

UV:

Ultraviolet

LB:

Luria–Bertani

MT:

Masson’s trichrome staining

H&E:

Hematoxylin and Eosin

SD:

Sprague–Dawley

FGF:

Fibroblast growth factor

DDS:

Drug delivery system

PFA:

Paraformaldehyde

HFIP:

1,1,1,3,3,3-Hexafluoro-2-propanol

T max :

Maximum degradation temperature

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Acknowledgements

This work was supported by Science and Technology Commission of Shanghai Municipality (No. 20S31900900, 20DZ2254900), Sino German Science Foundation Research Exchange Center (M-0263), Taishan Scholars Program of Shandong Province (tsqn201812141), Shandong Provincial Natural Science Foundation (ZR2021MH004) and Academic promotion program of Shandong First Medical University (2019RC016). This project was also supported by Researchers Supporting Project Number (RSP2023R65), King Saud University, Riyadh, Saudi Arabia, China Education Association for International Exchange (2022181) and Donghua University Postgraduate Innovation and Entrepreneurship Ability Training Program (yjssc2023002). This research was also partially supported by Grant-in-Aid for JSPS Research Fellows (JP21F21353). M.S. is an International Research Fellow of the Japan Society for the Promotion of Science (Postdoctoral Fellowships for Research in Japan (Standard)). M.S. is keenly grateful to the Gifu University, Japan for Special Cooperative Research Program and College of Biological Science and Medical Engineering, Donghua University, Shanghai, China for cooperative research.

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Author notes

  1. Zhengchao Yuan, Yue Zhao and Muhammad Shafiq contributed equally to this work.

Authors and Affiliations

  1. State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, College of Biological Science and Medical Engineering, Donghua University, Shanghai, 201620, People’s Republic of China

    Zhengchao Yuan, Yue Zhao, Jiahui Song, Xiao Yu, Yujie Chen, Fan Yu & Xiumei Mo

  2. Department of Chemical Engineering, Faculty of Engineering, Graduate School, Kyushu University, Fukuoka, 819-0395, Japan

    Muhammad Shafiq

  3. United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, 1-1 Yanagido, Gifu, 501-1193, Japan

    Muhammad Shafiq

  4. Department of Orthopedics, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, People’s Republic of China

    Jing Hou, Yuqing Liang & Shichao Jiang

  5. Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, 11451, Riyadh, Saudi Arabia

    Mohamed EL-Newehy & Hany EL-Hamshary

  6. Faculty of Engineering and Industrial Sciences, Swinburne University of Technology, Boroondara, VIC, 3122, Australia

    Yosry Morsi

  7. Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, 250117, People’s Republic of China

    Shichao Jiang

  8. Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, 200443, People’s Republic of China

    Hui Zheng

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  1. Zhengchao Yuan
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  2. Yue Zhao
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  7. Xiao Yu
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  8. Yujie Chen
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  9. Fan Yu
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  10. Mohamed EL-Newehy
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  11. Hany EL-Hamshary
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  12. Yosry Morsi
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  13. Shichao Jiang
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  14. Hui Zheng
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  15. Xiumei Mo
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Correspondence to Shichao Jiang, Hui Zheng or Xiumei Mo.

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Yuan, Z., Zhao, Y., Shafiq, M. et al. Multi-Functional Fibrous Dressings for Burn Injury Treatment with Pain and Swelling Relief and Scarless Wound Healing. Adv. Fiber Mater. 5, 1963–1985 (2023). https://doi.org/10.1007/s42765-023-00320-5

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