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The Nutriss Study: A New Approach to Calibrate Diet and Exercise in Long-Term Space Missions to Maintain Body Fat, Muscle and Fluid Homeostasis

Abstract

Energy balance maintenance is crucial to preserve astronaut’s wellness and quality of life during long-duration spaceflight and nutritional intervention can effectively counteract the detrimental effect of microgravity on skeletal muscle mass and metabolism. NutrISS (Nutrition monitoring for the International Space Station) is an Italian Space Agency (ASI) biomedical experiment investigating the changes in body composition during long-term spaceflight. The goal of this proof-of-concept study is to monitor the body composition of astronauts and, if needed, to provide nutritional advice during the mission. It has been executed on the ISS, from July 2019 till January 2020 and sponsored by ESA. The payloads selected for the mission “BEYOND” result from a public-call funded and coordinated by ASI, in the frame of its national mission of promoting and fostering the culture of space across the Country and providing access to the ISS as a laboratory in space to the Italian research community. The utilization support services is ensured by Argotec/Telespazio (UTISS Team). An astronaut underwent to baseline data collections, i.e. body composition, anthropometric evaluation and energy and metabolic assessment carried out by the scientific team. Body composition, estimated through resistance/reactance to a low-intensity current has been assessed with a Bio-Impedance Analyser (BIA) device manufactured by Akern and modified by Kayser Italia. To maintain the participant in near-neutral energy balance, the science team monitored monthly the astronaut body mass during the entire space flight period. Advice on energy intake was given to the astronaut when needed.

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Abbreviations

BIA:

BioImpedance analysis

BMMD:

Body mass measuring device

COTS:

Commercial off the shelf

ENA:

European nutritional assessment

FFM:

Fat-free mass

FM:

Fat mass

PA:

Phase angle

References

  1. Biolo, G., Ciocchi, B., Stulle, M., Bosutti, A., Barazzoni, R., Zanetti, M., Antonione, R., Lebenstedt, M., Platen, P., Heer, M., Guarnieri, G.: Calorie restriction accelerates the catabolism of lean body mass during 2 wk of bed rest. Am. J. Clin. Nutr. 86(2), 366–372 (2007). https://doi.org/10.1093/ajcn/86.2.366

    Article  Google Scholar 

  2. Biolo, G., Secchiero, P., De Giorgi, S., Tisato, V., Zauli, G.: The energy balance positively regulates the levels of circulating TNF-related apoptosis inducing ligand in humans. Clin. Nutr. 31(6), 1018–1021 (2012). https://doi.org/10.1016/j.clnu.2012.04.016

    Article  Google Scholar 

  3. Biolo, G., Agostini, F., Simunic, B., Sturma, M., Torelli, L., Preiser, J.C., Deby-Dupont, G., Magni, P., Strollo, F., di Prampero, P., Guarnieri, G., Mekjavic, I.B., Pisot, R., Narici, M.V.: Positive energy balance is associated with accelerated muscle atrophy and increased erythrocyte glutathione turnover during 5 wk of bed rest. Am. J. Clin. Nutr. 88(4), 950–958 (2008)

    Article  Google Scholar 

  4. Biolo, G., Heer, M., Narici, M., Strollo, F.: Microgravity as a model of ageing. Curr. Opin. Clin. Nutr. Metab. Care 6(1), 31–40 (2003). https://doi.org/10.1097/00075197-200301000-00006

    Article  Google Scholar 

  5. Smith, S.M., Zwart, S.R., Block, G., Rice, B.L., et al.: The nutritional status of astronauts is altered after long-term space flight aboard the International Space Station. J. Nutr. 135(3), 437–443 (2005)

    Article  Google Scholar 

  6. Smith, S.M., Zwart, S.R., Heer, M.: Human adaptation to space flight: the role of nutrition. National Aeronautics and Space Administration. Book. United States Govt Printing Office (2014)

  7. Wilson, M.M., Morley, J.E.: Aging and energy balance. J. Appl. Physiol. 95, 1728–1736 (2003)

    Article  Google Scholar 

  8. World Health Organization: Energy and protein requirements. Report of a joint FAO/WHO/UNU expert consultation. World Health Organization, Geneva (1985)

    Google Scholar 

  9. Institute of Medicine: Dietary reference intakes for energy, carbohydrate, fiber, fat, fatty acids, cholesterol, protein, and amino acids (macronutrients). The National Academies Press, Washington (2002)

    Google Scholar 

  10. Jaffrin, M.Y., Morel, H.: Body fluid volumes measurements by impedance: a review of bioimpedance spectroscopy (BIS) and bioimpedance analysis (BIA) methods. Med. Eng. Phys. 30(10), 1257–1269 (2008)

    Article  Google Scholar 

  11. Wang, J., Thornton, J.C., Burastero, S., Heymsfield, S.B., Pierson Jr., R.N.: Bio-impedance analysis for estimation of total body potassium, total body water, and fat-free mass in white, black, and Asian adults. Am. J. Hum. Biol. 7(1), 33–40 (1995)

    Article  Google Scholar 

  12. Noskov, V.B., Nichiporuk, I.A., Grigorev, A.I.: Dynamics of the body liquids and composition in long-duration space flight (bio-impedance analysis). Aviakosm Ekolog Med. 41(3), 3–7 (2007)

    Google Scholar 

  13. Noskov, V.B., Kotov, A.N., Morukov, B.V., Nichiporuk, I.A., Shargin, Y.: Bioimpedance analysis of fluids and body composition under the conditions of short-term space flight or hypokinesia. Hum. Physiol. 32(5), 622–625 (2006)

    Article  Google Scholar 

  14. Noskov, V.B., Nikolaev, D.V., Tuikin, S.A., Kozharinov, V.I., Grachev, V.A.: A portable impedance meter for monitoring liquid compartments of the human body under space flight conditions. Biomed. Eng. 41(2), 94–96 (2007)

    Article  Google Scholar 

  15. Wade, C.E., Miller, M.M., Baer, L.A., Moran, M.M., Steele, M.K., Stein, T.P.: Body mass, energy intake, and water consumption of rats and humans during space flight. Nutrition 18, 829–836 (2002)

    Article  Google Scholar 

  16. Rittweger, J., Albracht, K., Flück, M., Ruoss, S., Brocca, L., Longa, E., Moriggi, M., Seynnes, O., Di Giulio, I., Tenori, L., Vignoli, A., Capri, M., Gelfi, C., Luchinat, C., Francheschi, C., Bottinelli, R., Cerretelli, P., Narici, M.: Sarcolab pilot study into skeletal muscle's adaptation to long-term spaceflight. NPJ Microgravity 4, 18 (2018). https://doi.org/10.1038/s41526-018-0052-1

    Article  Google Scholar 

  17. Capri, M., Morsiani, C., Santoro, A., Moriggi, M., Conte, M., Martucci, M., Bellavista, E., Fabbri, C., Giampieri, E., Albracht, K., Flück, M., Ruoss, S., Brocca, L., Canepari, M., Longa, E., Di Giulio, I., Bottinelli, R., Cerretelli, P., Salvioli, S., Gelfi, C., Rittweger, J.: Recovery from 6-month spaceflight at the International space station: muscle-related stress into a proinflammatory setting. FASEB J. 33(4), 5168–5180 (2019). https://doi.org/10.1096/fj.201801625R

    Article  Google Scholar 

  18. Bettis, T., Kim, B.J., Hamrick, M.W.: Impact of muscle atrophy on bone metabolism and bone strength: implications for muscle-bone crosstalk with aging and disuse. Osteoporos Int. 29(8), 1713–1720 (2018). https://doi.org/10.1007/s00198-018-4570-1. Epub 2018 May 18

    Article  Google Scholar 

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Acknowledgements

NUTRISS has been funded, coordinated during both development and utilization phase by the Italian Space Agency (ASI). Furthermore, ASI executes the role of contract management and granted access to ISS resources through a dedicated agreement with ESA.

Funding

The study has been supported by an ASI Grant.

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Correspondence to N. Fiotti.

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The authors declare no conflict or competing interests.

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Obtained from JSC-IRB, ESA-MedOP IRB and CERU (for the University of Trieste).

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Di Girolamo, F.G., Biolo, G., Fiotti, N. et al. The Nutriss Study: A New Approach to Calibrate Diet and Exercise in Long-Term Space Missions to Maintain Body Fat, Muscle and Fluid Homeostasis. Aerotec. Missili Spaz. 99, 121–125 (2020). https://doi.org/10.1007/s42496-020-00044-4

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  • DOI: https://doi.org/10.1007/s42496-020-00044-4

Keywords

  • Body impedance
  • BIA
  • ISS
  • Nutrition in space