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Idiopathic Hypersomnia in a Patient Suffering from MELAS (Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Stroke-Like Episodes): a New Mitochondrial Feature?

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Abstract

Hypersomnia is a rare neurologic disorder characterized by an excessive daytime sleepiness with long naps, despite an undisturbed nocturnal sleep. The impaired daytime alertness and sleep inertia are different from general fatigue. This disorder is often classified as idiopathic. Here, we report the case of a young patient presenting both a mitochondrial disease and a hypersomnia. We discuss the links between the two pathologies and propose to systematically investigate personal and familial mitochondrial features in case of hypersomnia, to offer suitable genetic tests. Conversely, fatigue could be one of the complaints reported by patients with a confirmed mitochondrial disease, which is multifactorial. Sleep quality and somnolence should be examined in these patients as specific treatments exist for this debilitating disorder.

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Acknowledgements

David Seguy for patient’s care and Mylene Gilleron for metabolic investigations

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Authors and Affiliations

  1. Inserm, CHU Lille, U1172 - LilNCog - Lille Neuroscience & Cognition, Univ. Lille, F-59000, Lille, France

    Céline Tard, Grégory Kuchcinski, Luc Defebvre, Claire-Marie Dhaenens & Christelle Charley Monaca

  2. Clinique de neurologie, Unité d’expertise cognitivo-motrice, Centre de référence des maladies neuromusculaires Nord Est Ile de France, Lille, France

    Céline Tard

  3. Department of Neurology, Salengro Hospital, University Lille Hospital, Emile Laine Street, 59037, Lille cedex, France

    Céline Tard & Luc Defebvre

  4. Hôpital Huriez, Service d’Endocrinologie-Métabolisme et Centre de référence des maladies héréditaires du métabolisme, Lille University Hospital, Lille, France

    Claire Douillard

  5. Service de neuroradiologie, Lille, France

    Grégory Kuchcinski

  6. Centre de Biologie Pathologie Génétique, UF Métabolisme Général et Maladies Rares, CHU Lille, F-59000, Lille, France

    Anne-Frédérique Dessein

  7. Centre de Biologie Pathologie Génétique, UF Génopathies, CHU Lille, F-59000, Lille, France

    Claire-Marie Dhaenens

  8. Unité des troubles du sommeil, Service de neurophysiologie clinique, Lille, France

    Christelle Charley Monaca

Authors
  1. Céline Tard
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  2. Claire Douillard
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  3. Grégory Kuchcinski
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  4. Anne-Frédérique Dessein
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  5. Luc Defebvre
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  6. Claire-Marie Dhaenens
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  7. Christelle Charley Monaca
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Contributions

Céline Tard conceived the case report, collected the data, and wrote the paper; Claire Douillard contributed data; Grégory Kuchcinski contributed data; Anne-Frédérique Dessein contributed data; Luc Defebvre contributed the data analysis; Claire-Marie Dhaenens contributed data, data presentation, and edited the paper; and Christelle Charley Monaca contributed data and data presentation.

Corresponding author

Correspondence to Céline Tard.

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All procedures performed in this case report were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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The authors declare no competing interests.

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Tard, C., Douillard, C., Kuchcinski, G. et al. Idiopathic Hypersomnia in a Patient Suffering from MELAS (Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Stroke-Like Episodes): a New Mitochondrial Feature?. SN Compr. Clin. Med. 3, 2038–2041 (2021). https://doi.org/10.1007/s42399-021-00970-9

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  • DOI: https://doi.org/10.1007/s42399-021-00970-9

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