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Morphologically and Genetically Diagnosed Dermal Dioctophyme Larva in a Chinese Man: Case Report

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Abstract

We present a case of a nematode larva infection found in a cutaneous nodule excised from the left flank of a 48-year-old Chinese male, who was naturalized in Japan and comes and goes frequently to China and Japan. Clinical diagnosis at his first visit to a local hospital was epidermoid cyst. Pathological diagnosis of surgical specimen was cutaneous larva migrans and detailed morphological observation suggested that the worm in the subcutis was a dioctophimatid larva. DNA sequence analysis of the formalin-fixed and paraffin-embedded tissues revealed the larva as the giant kidney worm, Dioctophyme renale (Goeze, 1972).

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Authors and Affiliations

  1. Department of Diagnostic Pathology (DDP) & Research Center of Diagnostic Pathology (RC-DiP), Gifu Municipal Hospital, 7-1 Kashima-cho, Gifu City, Gifu, 500-8513, Japan

    Takuji Tanaka

  2. Laboratory of Veterinary Parasitology, School of Veterinary Medicine, Faculty of Veterinary Science, Nippon Veterinary and Life Science University, 1-7-1 Kyonancho, Musashino, Tokyo, 180-8602, Japan

    Toshihiro Tokiwa

  3. Department of Biomedicine and Department of Infectious Disease Control, Faculty of Medicine, Oita University, 1-1 Idaigaoka, Hasama, Yufu, 879-5593, Japan

    Hideo Hasegawa

  4. Parasitology Division, Department of Microbiology and Immunology, Aichi Medical University School of Medicine, Nagakute, Aichi, 480-1195, Japan

    Teruki Kadosaka, Makoto Itoh & Fumiaki Nagaoka

  5. Division of Parasitology, Department of Infectious Diseases, Faculty of Medicine, University of Miyazaki, 5200 Kiyotake-cho, Kihara, Miyazaki, 889-1692, Japan

    Haruhiko Maruyama

  6. Department of Dermatology, Gifu Municipal Hospital, 7-1 Kashima-cho, Gifu City, Gifu, 500-8513, Japan

    Yuki Mizuno & Hiroyuki Kanoh

  7. Department of Surgery, Hayatoku Hospital, 1-8-1 Usaminami, Gifu City, Gifu, 500-8367, Japan

    Naoki Shirai

Authors
  1. Takuji Tanaka
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  2. Toshihiro Tokiwa
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  3. Hideo Hasegawa
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  4. Teruki Kadosaka
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  5. Makoto Itoh
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  6. Fumiaki Nagaoka
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  7. Haruhiko Maruyama
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  8. Yuki Mizuno
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  9. Hiroyuki Kanoh
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  10. Naoki Shirai
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Contributions

Removal of the cutaneous tumor: Naoki Shirai.

Pathological diagnosis: Takuji Tanaka, Yuki Mizuno, and Hiroyuki Kanoh.

Morphological diagnosis of the parasite in the formalin-fixed paraffin-embedded specimen: Hideo Hasegawa, Haruhiko Maruyama, and Teruki Kadosaka.

Genetic analysis of the parasite in the formalin-fixed paraffin-embedded specimen: Toshihiro Tokiwa.

Serum assay (dot-ELISA): Makoto Itoh and Fumiaki Nagaoka.

Writing—original draft: Takuji Tanaka.

Writing—review and editing: Hideo Hasegawa, Toshihiro Tokiwa, and Teruki Kadosaka.

All authors have read and agreed with the final version of the manuscript.

Corresponding author

Correspondence to Takuji Tanaka.

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Conflict of Interest

The authors declare that they have no conflict of interests.

Ethical Approval

All procedures were in accordance with the Helsinki Declaration (World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects). JAMA. 2013; 310: 2191-4.

Patient Consent

Full written informed consent was given by the patient prior to examination.

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This article is part of the Topical Collection on Medicine

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Tanaka, T., Tokiwa, T., Hasegawa, H. et al. Morphologically and Genetically Diagnosed Dermal Dioctophyme Larva in a Chinese Man: Case Report. SN Compr. Clin. Med. 2, 468–471 (2020). https://doi.org/10.1007/s42399-020-00256-6

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  • DOI: https://doi.org/10.1007/s42399-020-00256-6

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