Hospitalization for asthma exacerbation is significantly related to overall poor asthma control. The study aimed to contrast post-hospitalization outcomes of those asthmatics who underwent serologic specific IgE (sIgE) testing for regional environmental allergens to an untested cohort. Of 8061 asthma encounters, 273 subjects who met the criteria were included in this retrospective cohort study. Those asthmatics identified with persistent disease were hospitalized at Miller Children’s Hospital during the period June 2008–October 2015. A total of 207 patients underwent sIgE testing during initial hospitalization for asthma and 66 were not tested. The Cox regression analysis assessed time from discharge to first emergency room (ER) visit, required systemic steroids, and next hospitalization in sIgE vs. non-tested groups, stratified by severity (mild or moderate-severe) and adjusted for age (≥ 12 or < 12), gender, and race. Serum allergy evaluation by sIgE testing reduced the hazard of an ER visit and systemic corticosteroids requirement by half in mild asthmatics (p < 0.05). The average time to next ER visit was almost 1 year in the allergy-tested group compared to < 6 months in the no-test group. Blood-based allergy evaluation as part of inpatient asthma treatment was shown to improve disease management specifically in time to next ER and/or exacerbation and systemic corticosteroids requirement in patients with mild disease. In more severe adolescent asthmatics, sIgE testing appeared protective against future hospitalization. Inpatient serologic testing may be beneficial in raising alertness in the asthma population, deploying early comprehensive care and lowering the rate of hospitalization.
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Financial support for this research activity includes MemorialCare Health System/Miller Children’s Hospital and The Translational Pulmonary and Immunology Research Center (TPIRC) of Long Beach, CA.
Conflict of Interest
The authors declare that they have no conflict of interest.
At a Glance Commentary: To date, no study has analyzed the efficacy of blood-based allergy evaluation (serologic sIgE testing) as part of inpatient asthma management to determine post-hospitalization asthma treatment and clinical outcomes. The goal of this study is to compare post-hospitalization outcomes of asthmatics who underwent objective allergy and lung function testing during initial hospitalization to a cohort which did not.
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Brock, J.P., Nussbaum, E., Morphew, T.L. et al. Allergy Evaluation During Hospitalized Asthma Improves Disease Management Outcomes. SN Compr. Clin. Med. 1, 328–333 (2019). https://doi.org/10.1007/s42399-019-0044-9
- Immunoglobulin E
- Status asthmaticus