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A Facile and Microwave Assisted Solvent Free Synthesis of Novel Indole Pyrimidine Imide Derivatives

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Abstract

A series of novel indole derivatives bearing pyrimidine and cyclic imide scaffolds such as phthalic and maleic anhydrides has been designed and synthesized using both conventional and microwave irradiation (MW) methods under solvent free conditions. The title compounds have been developed by the reaction of 2-aminoo-4-hydroxy-6-(5,1-substituted-indol-3-yl) pyrimidine-5-carbonitrile with phthalic and maleic anhydrides individually using MW method. In addition, these target compounds were also synthesised under conventional heating method. A considerable increase in the reaction rate has been observed with better yields (90–92%) within 2–6 min using microwave irradiation in comparison to conventional thermal treatment.

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Acknowledgements

The authors are thankful to the authorities of Jawaharlal Nehru Technological University, Hyderabad, for providing laboratory facilities.

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Authors and Affiliations

  1. Department of Chemistry, College of Engineering, Jawaharlal Nehru Technological University Hyderabad, Kukatpally, Hyderabad, Telangana, 500 085, India

    Mahesh Goud Bakkolla, Ashok Kumar Taduri & Rama Devi Bhoomireddy

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  1. Mahesh Goud Bakkolla
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  2. Ashok Kumar Taduri
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  3. Rama Devi Bhoomireddy
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Correspondence to Mahesh Goud Bakkolla.

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Bakkolla, M.G., Taduri, A.K. & Bhoomireddy, R.D. A Facile and Microwave Assisted Solvent Free Synthesis of Novel Indole Pyrimidine Imide Derivatives. Chemistry Africa 2, 587–595 (2019). https://doi.org/10.1007/s42250-019-00083-w

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