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Electrospun composite nanofibers for treating infectious esophagitis

Emergent Materials volume 6, pages 1549–1561 (2023)Cite this article

Abstract

The electrospinning technique enables the convenient fabrication of non-woven fibrous materials with excellent properties such as fine diameters, a large surface area per unit mass, high porosity, high gas permeability, and small pore sizes. Nanofiber applications in healthcare systems continue to be popular especially in recent years and are integrated with drug delivery systems in the treatment of diseases such as infectious esophagitis. For that reason, in this study, 13% polyvinyl alcohol (PVA), 0.5% gelatin (GEL), and 5, 10, and 15 mg of fluconazole (FCZ) were used to fabricate the drug-loaded nanofibers using the electrospinning method for local treatment of infectious esophagitis. The SEM images demonstrated the fibers’ homogeneous and beadless morphologies and the mean diameter of electrospun nanofibers ranged between 395±12 nm and 314±93 nm. With the addition of FCZ, the properties of electrospun nanofibers improved, and some shifts in FTIR peaks were observed. The thermal properties of the electrospun nanofiber were also improved, and the highest melting temperature of PVA was observed at 235 °C when the drug concentration was highest. The tensile strength of 13% PVA/0.5% GEL/15 FCZ electrospun nanofibers was the highest and resulted in 7.07±1.33 MPa. Moreover, the biocompatibility of electrospun nanofibers was tested on MSC cells, which were able to spread all over the electrospun nanofibers even on day 7, due to the biocompatibility of each electrospun nanofibers. In addition, the antimicrobial and drug release kinetics properties of the FCZ-loaded electrospun nanofiber patches were tested against S. aureus, S. agalactia, and C. albicans.

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Authors and Affiliations

  1. Center for Nanotechnology & Biomaterials Application and Research (NBUAM), Marmara University, Istanbul, Turkey

    Muge Koyun, Rabia Betul Sulutas, Yigit Turan, Hatice Karabulut, Armaghan Moradi, Huseyin Berkay Ozarici, Songul Ulag & Oguzhan Gunduz

  2. Institute of Pure and Applied Sciences, Department of Metallurgical and Materials Engineering, Marmara University, Istanbul, Turkey

    Muge Koyun, Rabia Betul Sulutas, Yigit Turan & Hatice Karabulut

  3. Department of Biomedical Engineering, Bahcesehir University, Istanbul, Turkey

    Armaghan Moradi

  4. Department of Metallurgical and Materials Engineering, Faculty of Technology, Marmara University, Istanbul, Turkey

    Songul Ulag & Oguzhan Gunduz

  5. Genetic and Metabolic Diseases Research and Investigation Center, Department of Biochemistry, Faculty of Medicine, Marmara University, Istanbul, Turkey

    Ali Sahin

  6. Institute of Health Sciences, Department of Microbiology, Marmara University, Istanbul, Turkey

    Mehmet Mucait Guncu

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  1. Muge Koyun
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  2. Rabia Betul Sulutas
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  3. Yigit Turan
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  4. Hatice Karabulut
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  6. Huseyin Berkay Ozarici
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  7. Songul Ulag
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  8. Ali Sahin
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  9. Mehmet Mucait Guncu
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  10. Oguzhan Gunduz
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Correspondence to Songul Ulag.

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Highlights

1. The use of the three materials for the treatment of infectious esophagitis has not yet been reported using the electrospinning method.

2. Nanofibrous scaffolds were successfully manufactured and demonstrated biocompatibility with mesenchymal stem cells.

3. The fluconazole addition increased the mechanical properties of the nanofibers.

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Koyun, M., Sulutas, R.B., Turan, Y. et al. Electrospun composite nanofibers for treating infectious esophagitis. emergent mater. 6, 1549–1561 (2023). https://doi.org/10.1007/s42247-023-00533-9

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  • DOI: https://doi.org/10.1007/s42247-023-00533-9

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