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One-dimensional microstructure-assisted intradermal and intracellular delivery

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Abstract

The advancement in the materials manufacturing at micrometer and nanometer scales has already enabled numerous applications in electronics, optics, chemistry, biology and medicine. Biomedical devices carrying micro-/nanostructures are currently being widely used in drug delivery, drug release, biosensing and therapy. New clinical methods for disease diagnosis and treatments are being developed enabled by nanotechnology. One-dimensional (1D) structures are playing an important role in the direct drug delivery both in vivo and ex vivo among various micro-/nanostructures. Here, in this paper, we reviewed recent progresses made on next-generation intradermal and intracellular delivery strategies and applications with focus on 1D microstructure-based approaches.

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Acknowledgements

The authors acknowledge the helpful discussions with Dr. Steven J. Jonas and Ms. Isaura M. Frost from University of California Los Angeles.

Funding

X.X. and W.J. acknowledges the support from Tongji University. L.M. acknowledges the support from National Natural Science Foundation of China under Grants 51875518, 81501607 and 51475419, Key Research and Development Projects of Zhejiang Province under Grant 2017C01054.

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Author notes

  1. Wensen Jiang and Liang Ma have contributed equally to this work.

Authors and Affiliations

  1. Materials Science and Engineering School, Tongji University, Shanghai, 201804, China

    Wensen Jiang & Xiaobin Xu

  2. State Key Laboratory of Fluid Power and Mechatronic Systems, Zhejiang University, Hangzhou, 310058, China

    Liang Ma

  3. School of Mechanical Engineering, Zhejiang University, Hangzhou, 310058, China

    Liang Ma

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  1. Wensen Jiang
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  2. Liang Ma
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Correspondence to Xiaobin Xu.

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WJ, L.M and X.X declare that they have no conflict of interest.

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This review does not contain any studies with human or animal subjects performed by any of the authors.

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Jiang, W., Ma, L. & Xu, X. One-dimensional microstructure-assisted intradermal and intracellular delivery. Bio-des. Manuf. 2, 24–30 (2019). https://doi.org/10.1007/s42242-019-00034-x

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