Three-dimensional bioprinting of gelatin methacryloyl (GelMA)


The three-dimensional (3D) bioprinting technology has progressed tremendously over the past decade. By controlling the size, shape, and architecture of the bioprinted constructs, 3D bioprinting allows for the fabrication of tissue/organ-like constructs with strong structural–functional similarity with their in vivo counterparts at high fidelity. The bioink, a blend of biomaterials and living cells possessing both high biocompatibility and printability, is a critical component of bioprinting. In particular, gelatin methacryloyl (GelMA) has shown its potential as a viable bioink material due to its suitable biocompatibility and readily tunable physicochemical properties. Current GelMA-based bioinks and relevant bioprinting strategies for GelMA bioprinting are briefly reviewed.

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The authors gratefully acknowledge funding from the National Institutes of Health (K99CA201603, R21EB025270, R21EB026175) and Doctoral New Investigator Grant from American Chemical Society Petroleum Research Fund (56840-DNI7). G. L. Y. acknowledges Natural and Science Foundation of Hubei Province (2014CFB778).

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Correspondence to Cunjiang Yu or Yu Shrike Zhang.

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Ying, G., Jiang, N., Yu, C. et al. Three-dimensional bioprinting of gelatin methacryloyl (GelMA). Bio-des. Manuf. 1, 215–224 (2018).

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  • Bioprinting
  • Bioink
  • Gelatin methacryloyl (GelMA)
  • Biofabrication
  • Tissue engineering
  • Tissue model