Arzneimittelsicherheit von Lokalanästhetika
Weinschenk S, Mergenthaler C, Armstrong C, Göllner R, Hollmann MW, Strowitzki T (2017) Local anesthetics, procaine, lidocaine, and mepivacaine show vasodilatation but no type 1 allergy: a double-blind, placebo-controlled study. BioMed Research International. https://doi.org/10.1155/2017/9804693
Therapy with local anesthetics (LAs), also known as neural therapy, is used in integrative medicine because of its anti-inflammatory properties. Ester-linked LAs are often avoided because of their alleged high allergenicity. Little data supports this assumption and hence the importance of our investigation on type-1 allergies against ester- and amide-linked LAs. We performed a prospective, double-blinded, placebo-controlled observational study.
177 patients received 340 intracutaneous injections with 1 % procaine, 0.5 % lidocaine, 1 % mepivacaine, or saline solution. Every patient received two different tests on each forearm. Reactions were...
Drug safety of local anesthetics
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