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Anabolic myokine responses and muscular performance following 8 weeks of autoregulated compared to linear resistance exercise in recreationally active males

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Abstract

Background

To date, no studies, to our knowledge, have compared the efficacy of autoregulated periodized and linear resistance exercises on anabolic myokines and muscular performance among recreationally active individuals. This study aimed to compare the effects of an 8-week autoregulated periodized resistance exercise (APRE) program with a linear resistance exercise (LRE) program on insulin-like growth factor-1 (IGF-1), follistatin (FST), myostatin (MST), body composition, muscular strength, and power in recreationally active males.

Methods

Thirty males were randomly assigned to either the APRE group (n = 15) or the LRE group (n = 15). Participants completed training three times a week for 8 weeks. The outcome measures included serum IGF-1, FST, MST, muscular strength (isometric knee extension and handgrip), power (vertical jump), lean body mass, and fat mass.

Results

IGF-1 circulating levels increased over time following APRE (34%) and with no significant change following LRE (~-1%). There were no significant differences over time or between groups for FST or MST. Muscular strength (knee extension [21.5 vs. ~16%] and handgrip [right: 31 vs. 25%; left: 31.7 vs. 28.8%]) and power (~ 33 vs. ~26%) significantly increased to a greater extent following APRE compared to LRE. Interestingly, the results revealed that lean body mass increased over time only after APRE (~ 3%), but not LRE.

Conclusion

These findings suggest that APRE may be more effective than LRE in increasing muscular strength, power, and lean body mass, as well as circulating IGF-1 levels, in recreationally active males. The observed differences may be attributed to the increased training volume associated with APRE. However, further research is needed to directly assess muscle protein synthesis.

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Authors and Affiliations

  1. Department of Exercise Physiology, Faculty of Sport Sciences, Ferdowsi University of Mashhad, Azadi Square, Mashhad, 9177948974, Iran

    Hamid Ghobadi, Seyyed Reza Attarzadeh Hosseini, Amir Rashidlamir & Gholam Rasul Mohammad Rahimi

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  1. Hamid Ghobadi
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  2. Seyyed Reza Attarzadeh Hosseini
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  3. Amir Rashidlamir
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  4. Gholam Rasul Mohammad Rahimi
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Correspondence to Seyyed Reza Attarzadeh Hosseini.

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Ethical approval

The study design and protocols were registered (IRCT20191231045963N1) and the ethics were approved by the Iran National Committee for Ethics in Biomedical Research (IR.UM.REC.1398.099) of the Ferdowsi University of Mashhad; the study was conducted in accordance with the ethical standards of the Deceleration of Helsinki.

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Ghobadi, H., Attarzadeh Hosseini, S., Rashidlamir, A. et al. Anabolic myokine responses and muscular performance following 8 weeks of autoregulated compared to linear resistance exercise in recreationally active males. Hormones (2024). https://doi.org/10.1007/s42000-024-00544-z

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