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Temporary hypothyroidism in severe crush syndrome: a potential novel entity

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Abstract

Background

Thyroid hormone synthesis is a complex process in the human body. Although the thyroid gland is essential for thyroid hormone synthesis, skeletal muscles also have crucial roles in thyroid hormone metabolism due to the deiodinase activities of the muscle cells. Hypothyroidism-related myopathy is a well-known entity. However, systemic effects of acute myopathies, such as rhabdomyolysis, on thyroid hormone metabolism have not to date been fully clarified.

Methods

Fifty-three earthquake victims were evaluated retrospectively. We investigated the thyroid function tests (TFTs) among patients with creatine kinase (CK) levels higher than 10.000 U/L at admission. Fifteen patients had CK levels higher than 10.000 U/L and 12 of them had data of TFTs, including thyroid stimulating hormone (TSH), free T4 (FT4), and free T3 (FT3) during hospitalization. These patients were evaluated.

Results

TSH levels were increased in all seven patients who required HD due to severe crush syndrome. Decreased FT4 levels were detected in 71.4% of them. None of the five non-HD patients had increased TSH levels or reduced FT4 levels. During follow-up, all patients survived. Renal and thyroid functions were normalized during follow-up without thyroxin replacement in patients with no prior history of hypothyroidism. Moreover, TFTs were normalized in two patients with history of hypothyroidism under thyroxine treatment without dose adjustments.

Conclusions

In severe forms of crush syndrome, temporary hypothyroidism might be seen. The exact mechanism underlying this entity is not well-known. Further clinical and experimental trials should be conducted to illuminate the mechanism of disrupted thyroid hormonogenesis in crush syndrome victims.

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Data availability

The data that support the findings of this study are available from the corresponding author upon reasonable request.

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Authors and Affiliations

  1. Department of Nephrology, University of Health Sciences, Bakırkoy Dr. Sadi Konuk Education and Research Hospital, Zuhuratbaba, Tevfik Sağlam Avenue, No: 11, Bakırkoy, 34147, Istanbul, Turkey

    Ahmet Burak Dirim, Gamze Ergun Sezer, Emine Uzun & Murvet Yilmaz

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  1. Ahmet Burak Dirim
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  2. Gamze Ergun Sezer
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Correspondence to Ahmet Burak Dirim.

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Dirim, A.B., Sezer, G.E., Uzun, E. et al. Temporary hypothyroidism in severe crush syndrome: a potential novel entity. Hormones 22, 603–609 (2023). https://doi.org/10.1007/s42000-023-00475-1

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  • DOI: https://doi.org/10.1007/s42000-023-00475-1

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