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A promising treatment for spontaneous ovarian hyperstimulation syndrome due to familial partial lipodystrophy: GnRH analogs combined with cyst aspiration

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Abstract

Purpose

To present a patient with familial partial lipodystrophy (FPLD) and polycystic ovary syndrome (PCOS) who was admitted with spontaneous ovarian hyperstimulation syndrome (OHSS)-like extremely enlarged ovaries, which was successfully treated using gonadotropin-releasing hormone analogs and abdominal cyst aspiration in combination.

Method

This is a descriptive case report of a single patient with FPLD and PCOS.

Results

Clinical improvement was achieved 6 months after therapy besides progressive reduction in total testosterone and DHEAS. Furthermore, there was a significant improvement in hyperinsulinemia and hypertriglyceridemia. Additionally, reduction in the size of ovarian cysts, reduction in the size and number of localizations of acanthosis nigricans, reduction in scores of mFGS, and weight loss were also observed.

Conclusion

Although there are few reports in the literature describing the association between PCOS with FPLD, management of this novel spontaneous OHSS-like condition has not yet been clearly defined. In the case of extremely enlarged multicystic ovaries and severe hyperandrogenemia, GnRH analogs may be considered to prevent ovarian enlargement and reduce hyperandrogenemia, especially when other treatment options are inappropriate.

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Data availability

The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions.

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Authors and Affiliations

  1. Department of Endocrinology and Metabolism, Ankara University School of Medicine, Ankara, Turkey

    Asena Gökçay Canpolat

  2. Department of Obstetrics and Gynaecology, Ankara University School of Medicine, Ankara, Turkey

    Batuhan Aslan & Yavuz Emre Şükür

Authors
  1. Asena Gökçay Canpolat
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  2. Batuhan Aslan
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  3. Yavuz Emre Şükür
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Contributions

All authors contributed to the study’s conception and design. The first draft of the manuscript was written by Asena Gökçay Canpolat and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

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Correspondence to Asena Gökçay Canpolat.

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The patient (B.V), gave written consent for the use of her personal medical records for the writing of this article.

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The authors declare no competing interests.

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Gökçay Canpolat, A., Aslan, B. & Şükür, Y.E. A promising treatment for spontaneous ovarian hyperstimulation syndrome due to familial partial lipodystrophy: GnRH analogs combined with cyst aspiration. Hormones 22, 741–745 (2023). https://doi.org/10.1007/s42000-023-00469-z

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