This is our first Editor’s Note of 2023, a year during which we anticipate that endocrine research will undoubtedly forge ahead at an ever increasing pace and Hormones will continue to publish impressive new data from laboratories and clinics around the world.
Unsurprisingly, 3 years after the first emergence of coronavirus disease 2019 (COVID-19), the virus itself being known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), there is an abundance of new data on the disease. As mentioned last summer , Hormones continues to have keen interest in COVID-19, the endocrine morbidity associated with it, as well as what was initially called “long-COVID-19” syndrome, also known as “post-COVID-19 conditions” (PCC): the latter condition may, in fact, be in large part due to hormonal dysfunction . The current issue of Hormones features reports and correspondence on the administration of the COVID-19 BNT162b2 mRNA vaccine, publications that add significantly to the field [3,4,5,6]. It is truly amazing what we are learning today about both the disease and the vaccinations together with their possible long-lasting effects. For example, a large cohort study recently identified a possible association between postural orthostatic tachycardia syndrome (POTS) and COVID-19 vaccination ; however, POTS is much more frequently associated with SARS-CoV-2 infection . Indeed, POTS may be in part an adrenal dysfunction syndrome. On the subject of POTS and other manifestations of COVID-19 and PCC, we will continue to encourage submissions to Hormones.
Although not a diabetes journal per se, Hormones publishes a fair amount of data and findings on diabetes research. The most recent publication by Chantzaras et al.  and studies by a number of other authors previously underscore our abiding interest in the causes and pathophysiology, genetics, and treatment, as well as clinical complications of the various types of diabetes. In this issue, there are two excellent studies on BNP levels and erectile dysfunction in type 2 diabetes mellitus [10, 11], one focusing on continuous insulin infusion treatment , as well as an animal study of diabetic peripheral neuropathy .
Endocrine genetics is a rapidly developing new component of endocrinology and of everyday clinical endocrine practice. This issue of Hormones includes observations recently made in children with neurofibromatosis type 1  and a case of salt-wasting congenital adrenal hyperplasia due to TNXA/TNXB chimera .
Publishing on pituitary and adrenal diseases forms, of course, a major part of any journal dedicated to endocrinology. The present issue of Hormones contains highly interesting and important articles on growth hormone excess and acromegaly [16,17,18] and on adrenal diseases and their diagnoses [19,20,21,22].
The other articles in this issue include Dellino et al.  who discuss the very important matter of hormone replacement therapy in patients who are carriers of the BRCA1 and BRCA2 gene variants that cause breast and ovarian cancers (while also predisposing to several other tumors). Sakiz et al.  have studied the prevalence and risk factors of simple renal cysts in primary hyperparathyroidism and Tripyla et al.  have evaluated the impact of classical music on pain and respiratory rate in patients after thyroidectomy. Although the latter study does not entirely belong to the field of endocrinology, there is no question that the effects of the arts, especially music, on pain perception and our patients’ comfort are in part hormonal , a crucial issue given the number of our patients who undergo surgery.
On behalf of our Editorial team, we wish to all a healthy and productive 2023. We thank you for your continuing support of Hormones and look forward to publishing yet again this year the best in all fields of endocrinology.
Constantine A. Stratakis
HORMONES, Editor in Chief
Stratakis CA (2022) Note by Hormones’ new editor: metabolic syndrome plus obesity and COVID-19, the two concurrent pandemics and the field of endocrinology. Hormones (Athens) 21(3):347–348. https://doi.org/10.1007/s42000-022-00390-x
Tomo S, Banerjee M, Karli S, Purohit P, Mitra P, Sharma P, Garg MK, Kumar B (2022) Assessment of DHEAS, cortisol, and DHEAS/cortisol ratio in patients with COVID-19: a pilot study. Hormones (Athens) 21(3):515–518. https://doi.org/10.1007/s42000-022-00382-x
Paschou SA, Karalis V, Psaltopoulou T, Charitaki I, Sklirou AD, Iconomidou VA, Vasileiou V, Kassi GN, Vryonidou A, Kokkinos A, Tentolouris N, Hatziaggelaki E, Trougakos IP, Terpos E, Dimopoulos MA (2022) COVID-19 BNT162b2 mRNA vaccine for patients with type 2 diabetes mellitus. Hormones (Athens) 11:1–2. https://doi.org/10.1007/s42000-022-00419-1
Yavropoulou MP, Sfikakis PP (2022) Cortisol and DHEAS in COVID-19. Hormones (Athens) 14:1–2. https://doi.org/10.1007/s42000-022-00417-3
Paschou SA, Karalis V, Psaltopoulou T, Charitaki I, Sklirou AD, Iconomidou VA, Vasileiou V, Kassi GN, Vryonidou A, Kokkinos A, Tentolouris N, Hatziaggelaki E, Trougakos IP, Terpos E, Dimopoulos MA (2022) Patients with type 2 diabetes mellitus present similar immunological response to COVID-19 BNT162b2 mRNA vaccine to healthy subjects: a prospective cohort study. Hormones (Athens) 21:1–7. https://doi.org/10.1007/s42000-022-00405-7
Sookaromdee P, Wiwanitkit V (2022) Patients with type 2 diabetes mellitus and response to COVID-19 BNT162b2 mRNA vaccine: correspondence. Hormones (Athens) 11:1–2. https://doi.org/10.1007/s42000-022-00420-8
Kwan AC, Ebinger JE, Wei J et al (2022) Apparent risks of postural orthostatic tachycardia syndrome diagnoses after COVID-19 vaccination and SARS-Cov-2 Infection. Nat Cardiovasc Res 1:1187–1194. https://doi.org/10.1038/s44161-022-00177-8
Rubin R (2023) Largecohort study finds possible association between postural orthostatic tachycardia syndrome and COVID-19 vaccination but far stronger link with SARS-CoV-2 infection. JAMA 329(6):454–456. https://doi.org/10.1001/jama.2023.0050
Chantzaras A, Yfantopoulos J (2022) Association between medication adherence and health-related quality of life of patients with diabetes. Hormones (Athens) 21(4):261–705. https://doi.org/10.1007/s42000-022-00400-y
Zhang Z, Chen Y, Wang Q, Xie L, Shan Y, Yang N, Wu W (2022) Influence of fasting plasma glucose-lowering rate on BNP levels in type 2 diabetes mellitus patients with coronary microcirculation dysfunction. Hormones (Athens). https://doi.org/10.1007/s42000-022-00404-8
Coppola A, Gallotti P, Montalcini T, Terruzzi I, Pujia A, Luzi L, Gazzaruso C (2022) Association of erectile dysfunction with diabetic foot and its outcomes in type 2 diabetic men. Hormones (Athens). https://doi.org/10.1007/s42000-022-00407-5
Figueiredo AR, Matos T, do Vale S (2022) Monitoring of continuous subcutaneous insulin infusion treatment in Portugal and its implications for diabetes management. Hormones (Athens). https://doi.org/10.1007/s42000-022-00412-8.
Zhang T, Zhang D, Zhang Z, Tian J, An J, Zhang W, Ben Y (2022) Alpha-lipoic acid activates AMPK to protect against oxidative stress and apoptosis in rats with diabetic peripheral neuropathy. Hormones (Athens). https://doi.org/10.1007/s42000-022-00413-7
Pinheiro SL, Maciel J, Cavaco D, Figueiredo AA, Damásio IL, Donato S, Passos J, Simões-Pereira J (2022) Precocious and accelerated puberty in children with neurofibromatosis type 1: results from a close follow-up of a cohort of 45 patients. Hormones (Athens). https://doi.org/10.1007/s42000-022-00411-9
Fanis P, Skordis N, Phylactou LA, Neocleous V (2022) Salt-wasting congenital adrenal hyperplasia phenotype as a result of the TNXA/TNXB chimera 1 (CAH-X CH-1) and the pathogenic IVS2-13A/C > G in CYP21A2 gene. Hormones (Athens). https://doi.org/10.1007/s42000-022-00410-w
Mutlu U, Telci Caklili O, Barburoglu M, Yarman S (2022) Frequency of hyperostosis frontalis interna in patients with active acromegaly: is there a possible role of GH excess or hyperprolactinemia in its etiopathogenesis? Hormones (Athens). https://doi.org/10.1007/s42000-022-00401-x
Ozisik H, Yurekli BS, Suner A, Copur O, Sozmen EY, Ozbek SS, Karabulut AK, Simsir IY, Erdogan M, Cetinkalp S, Saygili F (2022) High chitotriosidase and AGE levels in acromegaly: a case-control study. Hormones (Athens). https://doi.org/10.1007/s42000-022-00409-3
Koroglu EP, Soyaltin UE, Yeral S, Yurekli BS (2022) An acromegaly case treated with clomiphene citrate: add-on treatment in primary medical therapy. Hormones (Athens). https://doi.org/10.1007/s42000-022-00414-6
Araujo-Castro M, García Cano AM, Escobar-Morreale HF, Valderrabano P (2022) Predictive model for autonomous cortisol secretion development in non-functioning adrenal incidentalomas. Hormones (Athens). https://doi.org/10.1007/s42000-022-00406-6
Gubbi S, Mathias P, Palaiodimos L, Hulkower R, Schubart U (2022) The clinical utility of plasma and urine metanephrines in hypertensive emergency. Hormones (Athens). https://doi.org/10.1007/s42000-022-00422-6
Maciel J, Cavaco D, Fraga D, Donato S, Simões H, Sousa R, Simões-Pereira J (2022) Adrenal findings in FDG-PET: analysis of a cohort of 1021 patients from a cancer center. Hormones (Athens). https://doi.org/10.1007/s42000-022-00423-5
Giannakopoulos A, Sertedaki A, Efthymiadou A, Chrysis D (2022) Addison's disease without hyperpigmentation in pediatrics: pointing towards specific causes. Hormones (Athens). https://doi.org/10.1007/s42000-022-00415-5
Loizzi V, Dellino M, Cerbone M, Arezzo F, Chiariello G, Lepera A, Cazzato G, Cascardi E, Damiani GR, Cicinelli E, Cormio G (2023) Hormone replacement therapy in BRCA mutation carriers: how shall we do no harm? Hormones (Athens). https://doi.org/10.1007/s42000-022-00427-1
Sakız D, Sencar ME, Çalapkulu M, Ünsal İÖ, Kızılgül M, Uçan B, Özbek M, Çakal E (2022) Prevalence and associated risk factors of simple renal cysts in primary hyperparathyroidism. Hormones (Athens). https://doi.org/10.1007/s42000-022-00416-4
Tripyla N, Katsas K, Karagkouni K, Liosis I, Ntelis S, Linos D (2022) Evaluation of the effect of Mozart music on pain and respiratory rate after thyroidectomy. Hormones (Athens). https://doi.org/10.1007/s42000-022-00421-7
Schaal NK, Brückner J, Wolf OT, Ruckhäberle E, Fehm T, Hepp P (2021) The effects of a music intervention during port catheter placement on anxiety and stress. Sci Rep 11(1):5807. https://doi.org/10.1038/s41598-021-85139-z
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Stratakis, C.A. COVID-19, diabetes mellitus type 2, endocrine genetics, and pituitary and adrenal diseases. Hormones 22, 1–2 (2023). https://doi.org/10.1007/s42000-023-00436-8