To investigate current practices of specialists in the use of thyroid hormone preparations in Greece as part of an ongoing international survey, namely THESIS—Treatment of Hypothyroidism in Europe by Specialists: an International Survey.
An electronic link leading to an anonymized questionnaire was sent to all (n = 837) members of the Hellenic Endocrine Society.
In total, 501 respondents participated in the survey, though only part of the questionnaire was filled in by some participants. A total of 88.2% were endocrinologists and 57.9% worked in private practice. Levothyroxine (LT4) was the first-line choice (98.6%) for the treatment of hypothyroid patients. In total, 70.2% preferred LT4 soft-gel capsules for patients reporting intolerance to various foods. Soft-gel capsules were the preferred LT4 formulation for patients on generic LT4 and with unexplained poor biochemical control of hypothyroidism (66.3%) or inability to take LT4 fasted and separate from food/drink (68.3%). It was found that 48.4% would never use combined LT4 + LT3. However, 25% would use combination therapy for a short period in patients recovering from protracted hypothyroidism or in patients with normal serum TSH but persistent symptoms. Concerning euthyroid individuals, 31.9% considered treatment with thyroid hormones in infertile females with positive thyroid antibodies and 24.4% in patients with growing goiter. Selenium or iodine supplementation was used occasionally, mostly in patients with coexisting autoimmune thyroiditis.
LT4 tablets are the treatment of choice for hypothyroidism in Greece. Several conditions may lead to various other practices, some of which deviate from current evidence-based guidelines and need more scrutiny.
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Ethical approval was not required.
Consent to participate
A signed informed consent was not required from participants in this anonymous and voluntary questionnaire survey.
Conflict of interest
THESIS is supported by IBSA Institut Biochimique SA. PP, LH, EVN, and EP are scientific board members of and have received consultancy fees from IBSA Biochimique. IBSA had no role in the design of the survey, data analysis, data presentation, data interpretation, or writing the manuscript.
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THESIS - Treatment of Hypothyroidism in Europe by Specialists: An International Survey
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Paschou, S.A., Alevizaki, M., Attanasio, R. et al. Use of thyroid hormones in hypothyroid and euthyroid patients: a 2020 THESIS questionnaire survey of members of the Hellenic Endocrine Society.. Hormones (2021). https://doi.org/10.1007/s42000-021-00335-w
- Thyroid hormones
- Autoimmune thyroiditis