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Improvement of anti-Müllerian hormone and oxidative stress through regular exercise in Chinese women with polycystic ovary syndrome

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Abstract

Purpose

Structured exercise is shown to be one of the most effective lifestyle interventions for women with polycystic ovary syndrome (PCOS). Anti-Müllerian hormone (AMH) has been proposed as a marker of ovarian dysfunction, and oxidative stress plays an important role in the development of PCOS. We sought to investigate whether there was any effect of aerobic exercise on AMH levels and oxidative stress in Chinese PCOS women.

Methods

Thirty-eight PCOS women were enrolled and divided into two groups. The exercise group carried out a 12-week exercise program, while the control group maintained their normal lifestyle. All women underwent blood tests and cardiopulmonary exercise tests (CPETs) at enrollment and at 12-week follow-up.

Results

At baseline, there was no statistically significant difference between the two groups in clinical characteristics, AMH, oxidative biomarkers, and CPET parameters. After 12 weeks, body mass index (BMI) and cardiovascular fitness indexes of the exercise group were improved. We also found a decrease in AMH (P = 0.021) and malondialdehyde (MDA) (P = 0.002) and an increase in superoxide dismutase (SOD) (P = 0.009) and total antioxidant capacity (TAC) (P = 0.012) in the exercise group, while there was no change in the control group. Moreover, the change of AMH was positively associated with the change of MDA (r = 0.23, P = 0.003) in the exercise group.

Conclusions

Our findings demonstrated that 12 weeks of aerobic exercise produced beneficial effects on BMI, cardiovascular fitness, AMH, and oxidative stress in PCOS women. Favorable modification of oxidative stress might thus be an effective method for improvement of AMH in these women, which deserves further exploration in the future.

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Author information

Author notes

  1. Xia Wu and Heng Wu contributed equally to this work.

Authors and Affiliations

  1. Department of Endocrinology, Jing’an District Centre Hospital of Shanghai (Huashan Hospital Fudan University Jing’an Branch), Shanghai, China

    Xia Wu

  2. Department of Psychosomatic Medicine, Shanghai Tongji Hospital, School of Medicine, Tongji University, Shanghai, China

    Heng Wu

  3. Department of Rehabilitation, Shanghai General Hospital, Jiaotong University, Shanghai, China

    Wenjiang Sun

  4. Department of General Medicine, Shanghai Tongji Hospital, School of Medicine, Tongji University, Shanghai, China

    Chen Wang

Authors
  1. Xia Wu
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  2. Heng Wu
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  3. Wenjiang Sun
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  4. Chen Wang
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Correspondence to Chen Wang.

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Ethical approval

The study was approved by the Ethics Committee of Shanghai Tongji Hospital Affiliated to Tongji University (Approval number: 2017TJ-021).

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All participants gave their informed consent prior to information collection.

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Wu, X., Wu, H., Sun, W. et al. Improvement of anti-Müllerian hormone and oxidative stress through regular exercise in Chinese women with polycystic ovary syndrome. Hormones 20, 339–345 (2021). https://doi.org/10.1007/s42000-020-00233-7

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  • DOI: https://doi.org/10.1007/s42000-020-00233-7

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