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Hormones

, Volume 18, Issue 3, pp 267–272 | Cite as

Radiosensitivity-related postirradiation hypothyroidism in Graves’ disease patients

  • Xi Jia
  • Kun Guo
  • Rui Gao
  • Yan Yu
  • Aimin YangEmail author
Original article

Abstract

Purpose

The cumulative incidence of hypothyroidism, in 131I-treated patients with hyperthyroidism caused by Graves’ disease, has been gradually increasing each year. Meanwhile, the role of the genes that control radiation sensitivity (GCRS) involved in 131I therapy is yet to be defined. The main purpose of the present study is to find GCRS that could indicate hypothyroidism in Graves’ disease patients treated with 131I.

Methods

Thyroid tissue was collected from 59 patients who were diagnosed with Graves’ disease. GCRS (including Bcl-2, NF-κB, Survivin, Ku-70, Tob1, EGFR, Egr-1, TP-53, BRCA-1, and ATM) mRNA levels were analyzed with qRT-PCR before radioiodine therapy. Patients were followed up and then grouped by end-point outcomes. The association of the variation of target genes with susceptibility to hypothyroidism was analyzed.

Results

Altogether 44 patients were enrolled, including 11 men and 33 women with an average age of 44.79 ± 12.94 years. Based on their clinical outcomes after at least 2-year follow-up, 59% (26/44) patients were evaluated as hypothyroid, while the remaining 41% (18/44) patients were non-hypothyroid, including 18% (8/44) with persistent hyperthyroidism. The hypothyroid group showed significantly lower Ku-70 mRNA expression levels than the non-hypothyroid group (p = 0.022), whereas no significance was detected regarding other target genes (p > 0.1). Multivariate analysis showed that Ku-70 was significantly correlated with hypothyroidism after 131I treatment (p = 0.033).

Conclusions

The opposing changes in mRNA expression levels of Ku-70 in patients with hypothyroidism indicate its potential as a prognostic marker for hypothyroidism induced by 131I treatment.

Keywords

Hyperthyroidism 131I therapy Hypothyroidism Ku-70 Radiosensitivity 

Notes

Acknowledgments

We thank all staff of the Nuclear Medicine Department of the First Affiliated Hospital of Xi’an Jiaotong University College of Medicine for their support. We thank Ramone A. Williamson for the help with the manuscript.

Funding information

The project was supported by the National Natural Science Foundation of China (Grant Nos. 81871389, 81172598).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Hellenic Endocrine Society 2019

Authors and Affiliations

  1. 1.Department of Nuclear Medicine, First Affiliated HospitalMedical School of Xi’an Jiaotong UniversityXi’anChina
  2. 2.Department of Nuclear Medicine, Xuanwu HospitalCapital Medical UniversityBeijingChina
  3. 3.Department of Public HealthMedical College of Xi’an Jiaotong UniversityXi’anPeople’s Republic of China

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