European Geriatric Medicine

, Volume 9, Issue 5, pp 729–730 | Cite as

Hydrogen inhalation positively affects cardiometabolic risk factors in men and women aged 65 years or older: a preliminary report

  • Darinka Korovljev
  • Valdemar Stajer
  • Dejan Javorac
  • Sergej M. OstojicEmail author
Letter to the editor

To the Editor,

Molecular hydrogen (H2) has been recently introduced as an experimental medical gas in clinical medicine [1]. Beneficial effects of H2 are attributed to its antioxidant, anti-apoptotic and anti-inflammatory properties, with H2 administered via oral, parenteral or inhalational route found beneficial in cardiometabolic disorders [2]. However, no information is currently available concerning its efficacy and safety to affect cardiometabolic risk factors in elderly. This population faces the highest risk for cardiometabolic morbidity [3], and any intervention that would help improve cardiometabolic profiles is highly required.

In this pilot study, we evaluated the impact of short-term H2 inhalation on the American Heart Association (AHA) cardiovascular risk scores, health-related physical fitness, and cardiometabolic biomarkers in men and women aged 65 years or older. Sixteen (n = 16) community-dwelling aged adults (14 women and 2 men; age 68.1 ± 5.3 years; BMI...



Supported by the Serbian Ministry of Education, Science and Technological Development (#175037) and the Provincial Secretariat for Science and Technological Development (#114-451-710).

Compliance with ethical standards

Conflict of interest

The authors declare no conflict of interest.

Ethical approval

All procedures were approved by the local institutional review board at the University of Novi Sad, in accordance with the Declaration of Helsinki.

Informed consent

All participants signed an informed consent to voluntarily participate in this trial.


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    Song G, Li M, Sang H et al (2013) Hydrogen-rich water decreases serum LDL-cholesterol levels and improves HDL function in patients with potential metabolic syndrome. J Lipid Res 54:1884–1893CrossRefPubMedPubMedCentralGoogle Scholar
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    Chung JY, Kang HT, Lee DC et al (2013) Body composition and its association with cardiometabolic risk factors in the elderly: a focus on sarcopenic obesity. Arch Gerontol Geriatr 56:270–278CrossRefPubMedGoogle Scholar
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    Ostojic SM (2017) Does H2 alter mitochondrial bioenergetics via GHS-R1α activation? Theranostics 7:1330–1332CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© European Geriatric Medicine Society 2018

Authors and Affiliations

  1. 1.FSPE Applied Bioenergetics Lab, Faculty of Sport and Physical EducationUniversity of Novi SadNovi SadSerbia
  2. 2.University of Belgrade School of MedicineBelgradeSerbia

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