Sarcopenic osteoarthritis: a new entity in geriatric medicine?
- 91 Downloads
Osteoarthritis, a disease characterized by cartilage degradation, abnormal subchondral bone remodeling and some grade of inflammation, and sarcopenia, a condition of low muscle mass associated with reduced strength and function, are prevalent disorders in older adults. In this review, we examine what is known about the relationship between osteoarthritis and sarcopenia, with particular focus on the older population. We also discuss how osteoarthritis and sarcopenia may interact and affect each other in clinical progression and the potential benefits from developing treatments that address such muscular-skeletal interaction.
We searched in Pubmed and Scopus through a combination of search and MESH terms, for osteoarthritis and sarcopenia.
Even if more literature is needed, there is increasing evidence that decline in lower limb muscle strength is associated with knee or hip osteoarthritis in a pathological network of pain, altered joint stability, maladapted postures and defective neuromuscular communication. At the cellular levels, chondrocytes and myoblasts share common pathways, and the close anatomical location of both cell types also suggest the possibility of paracrine communication.
Sarcopenia and osteoarthritis are significantly intercorrelated and in the near future should be considered as an only entity, as we have recently proposed for sarcopenia and osteoporosis. The treatment of both sarcopenia and osteoarthritis is based on physical exercise and nutritional interventions with the aim of improving cartilage, bone and muscle health. Future studies are needed, particularly to know the exact prevalence of sarcopenia in people with osteoarthritis, its peculiar consequences and the most appropriate treatments.
KeywordsSarcopenia Osteoarthritis Physical performance Therapy
We sincerely thank prof. Luigi Ferrucci, National Istitutes of Aging, Baltimore, MD, USA for his careful revision of this manuscript.
This work was not supported by any funding. This review is a product of the Task and Finish Group on “Arthritis” of the European Geriatric Medicine Society.
Compliance with ethical standards
Conflict of interest
None of the authors have any financial arrangements, organizational affiliations or other relationships that might give rise to any conflict of interest regarding the subject matter of the manuscript submitted.
This article does not contain any studies with human participants performed by any of the authors.
For this type of study formal consent is not required.
- 1.Cruz-Jentoft AJ, Baeyens JP, Bauer JM, Boirie Y, Cederholm T, Landi F et al (2010) Sarcopenia: European consensus on definition and diagnosis: report of the European working group on sarcopenia in older people. Age Ageing 39(4):412–423. https://doi.org/10.1093/ageing/afq034 CrossRefPubMedPubMedCentralGoogle Scholar
- 4.Bernabei R, Mariotti L, Bordes P, Roubenoff R (2017) The, “sarcopenia and physical frailty in older people: multi-component treatment strategies” (SPRINTT) project: advancing the care of physically frail and sarcopenic older people. Aging Clin Exp Res 29(1):1–2. https://doi.org/10.1007/s40520-016-0707-2 CrossRefPubMedGoogle Scholar
- 9.Byeon CH, Kang KY, Kang SH, Kim HK, Bae EJ (2016) Sarcopenia is not associated with depression in Korean adults: results from the 2010–2011 Korean National Health and Nutrition Examination Survey. Korean J Fam Med 37(1):37–43. https://doi.org/10.4082/kjfm.2016.37.1.37 CrossRefPubMedPubMedCentralGoogle Scholar
- 19.Castell MV, van der Pas S, Otero A, Siviero P, Dennison E, Denkinger M et al (2015) Osteoarthritis and frailty in elderly individuals across six European countries: results from the European Project on OSteoArthritis (EPOSA). BMC Musculoskelet Disord 16:359. https://doi.org/10.1186/s12891-015-0807-8 CrossRefPubMedPubMedCentralGoogle Scholar
- 20.Schaap LA, Peeters GMEE, Dennison EM, Zambon S, Nikolaus T, Sanchez-Martinez M et al (2011) European Project on Osteoarthritis (EPOSA): methodological challenges in harmonization of existing data from five European population-based cohorts on aging. BMC Musculoskelet Disord 12:272. https://doi.org/10.1186/1471-2474-12-272 CrossRefPubMedPubMedCentralGoogle Scholar
- 24.Veronese N, Trevisan C, De Rui M, Bolzetta F, Maggi S, Zambon S et al (2016) Association of osteoarthritis with increased risk of cardiovascular diseases in the elderly: findings from the progetto veneto anziano study cohort. Arthr Rheumatol (Hoboken, NJ) 68(5):1136–1144. https://doi.org/10.1002/art.39564 Google Scholar
- 30.Veronese N, Stubbs B, Noale M, Solmi M, Luchini C, Maggi S (2016) Adherence to the Mediterranean diet is associated with better quality of life: data from the osteoarthritis initiative. Am J Clin Nutr 104(5):1403–1409. https://doi.org/10.3945/ajcn.116.136390 CrossRefPubMedPubMedCentralGoogle Scholar
- 33.Edwards MH, van der Pas S, Denkinger MD, Parsons C, Jameson KA, Schaap L et al (2014) Relationships between physical performance and knee and hip osteoarthritis: findings from the European Project on Osteoarthritis (EPOSA). Age Ageing 43(6):806–813. https://doi.org/10.1093/ageing/afu068 CrossRefPubMedPubMedCentralGoogle Scholar
- 35.Chaisson CE, Zhang Y, Sharma L, Kannel W, Felson DT (1999) Grip strength and the risk of developing radiographic hand osteoarthritis: results from the Framingham Study. Arthr Rheum 42(1):33–38. doi: 10.1002/1529-0131(199901)42:1<33::AID-ANR4>3.0.CO;2-IGoogle Scholar
- 36.Kemmler W, Teschler M, Goisser S, Bebenek M, von Stengel S, Bollheimer LC et al (2015) Prevalence of sarcopenia in Germany and the corresponding effect of osteoarthritis in females 70 years and older living in the community: results of the FORMoSA study. Clin Interven Aging 10:1565–1573. https://doi.org/10.2147/cia.s89585 CrossRefGoogle Scholar
- 37.Wang Y, Wluka AE, Berry PA, Siew T, Teichtahl AJ, Urquhart DM et al (2012) Increase in vastus medialis cross-sectional area is associated with reduced pain, cartilage loss, and joint replacement risk in knee osteoarthritis. Arthr Rheum 64(12):3917–3925. https://doi.org/10.1002/art.34681 CrossRefGoogle Scholar
- 47.Andriamanalijaona R, Duval E, Raoudi M, Lecourt S, Vilquin JT, Marolleau JP et al (2008) Differentiation potential of human muscle-derived cells towards chondrogenic phenotype in alginate beads culture. Osteoarthr Cartil 16(12):1509–1518. https://doi.org/10.1016/j.joca.2008.04.018 CrossRefPubMedGoogle Scholar
- 52.Vlietstra L, Meredith-Jones K, Stebbings S, Abbott JH, Treharne GJ, Waters DL (2017) Sarcopenic obesity is more prevalent in osteoarthritis than rheumatoid arthritis: are different processes involved? Rheumatol (Oxf, Engl) 56(10):1816–1818. https://doi.org/10.1093/rheumatology/kex303 CrossRefGoogle Scholar
- 56.Landi F, Cesari M, Calvani R, Cherubini A, Di Bari M, Bejuit R et al (2017) The “sarcopenia and physical frailty in older people: multi-componenT Treatment strategies” (SPRINTT) randomized controlled trial: design and methods. Aging Clin Exp Res 29(1):89–100. https://doi.org/10.1007/s40520-016-0715-2 CrossRefPubMedGoogle Scholar
- 58.Brosseau L, Taki J, Desjardins B, Thevenot O, Fransen M, Wells GA et al (2017) The Ottawa panel clinical practice guidelines for the management of knee osteoarthritis. Part three: aerobic exercise programs. Clin Rehabil 31(5):612–624. https://doi.org/10.1177/0269215517691085 CrossRefPubMedGoogle Scholar
- 66.Shahar DR, Houston DK, Hue TF, Lee J-S, Sahyoun NR, Tylavsky FA et al (2012) Adherence to Mediterranean diet and decline in walking speed over 8 years in community-dwelling older adults. J Am Geriatr Soc 60(10):1881–1888. https://doi.org/10.1111/j.1532-5415.2012.04167.x CrossRefPubMedPubMedCentralGoogle Scholar
- 68.Rizzoli R, Boonen S, Brandi ML, Bruyere O, Cooper C, Kanis JA et al (2013) Vitamin D supplementation in elderly or postmenopausal women: a 2013 update of the 2008 recommendations from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO). Curr Med Res Opin 29(4):305–313. https://doi.org/10.1185/03007995.2013.766162 CrossRefPubMedGoogle Scholar
- 69.Cianferotti L, Cricelli C, Kanis JA, Nuti R, Reginster JY, Ringe JD et al (2015) The clinical use of vitamin D metabolites and their potential developments: a position statement from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) and the International Osteoporosis Foundation (IOF). Endocrine 50(1):12–26. https://doi.org/10.1007/s12020-015-0606-x CrossRefPubMedGoogle Scholar
- 73.Bauer JM, Verlaan S, Bautmans I, Brandt K, Donini LM, Maggio M et al (2015) Effects of a vitamin D and leucine-enriched whey protein nutritional supplement on measures of sarcopenia in older adults, the PROVIDE study: a randomized, double-blind, placebo-controlled trial. J Am Med Dir Assoc 16(9):740–747. https://doi.org/10.1016/j.jamda.2015.05.021 CrossRefPubMedGoogle Scholar
- 75.McAlindon T, LaValley M, Schneider E et al (2013) Effect of vitamin d supplementation on progression of knee pain and cartilage volume loss in patients with symptomatic osteoarthritis: a randomized controlled trial. JAMA 309(2):155–162. https://doi.org/10.1001/jama.2012.164487 CrossRefPubMedPubMedCentralGoogle Scholar