European Geriatric Medicine

, Volume 9, Issue 2, pp 169–174 | Cite as

Proton pump inhibitors therapy and the risk of hip fracture in older people in Taiwan

  • Shih-Wei Lai
  • Chih-Hsueh Lin
  • Cheng-Li Lin
  • Kuan-Fu Liao
Research Paper



Conflicting results exist on the relationship between proton pump inhibitors use and hip fracture in old people. The objective of the paper was to explore this issue in Taiwan.


We conducted a population-based case–control study using the database of the Taiwan National Health Insurance Program. Cases included subjects aged 65 years and over with newly diagnosed hip fracture between 2000 and 2013 (n = 7208). Controls included subjects aged 65 years and over without a diagnosis of hip fracture (n = 7208). The cases and the controls were matched with sex, age, comorbidities, and index year of diagnosing hip fracture. The odds ratio and 95% confidence interval for hip fracture associated with proton pump inhibitors use were estimated by the multivariable logistic regression model.


The adjusted odds ratio of hip fracture was 0.96 for subjects with current use of proton pump inhibitors (95% confidence interval 0.76, 1.22), 1.17 for subjects with recent use (95% confidence interval 0.90, 1.52), and 1.12 for subjects with late use (95% confidence interval 0.91, 1.38), compared with never use.


No significant association can be detected between proton pump inhibitors use and the risk of hip fracture in older people in Taiwan.


Aged Hip fractures Old people Proton pump inhibitors National Health Insurance Program Taiwan 



This study was supported in part by Taiwan Ministry of Health and Welfare Clinical Trial Center (MOHW106-TDU-B-212-113004), China Medical University Hospital, Academia Sinica Taiwan Biobank Stroke Biosignature Project (BM10601010036), Taiwan Clinical Trial Consortium for Stroke (MOST 106-2321-B-039-005), Tseng-Lien Lin Foundation, Taichung, Taiwan, Taiwan Brain Disease Foundation, Taipei, Taiwan, and Katsuzo and Kiyo Aoshima Memorial Funds, Japan. These funding agencies did not influence the study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Author contributions

Shih-Wei Lai contributed to the conception of the article, initiated the draft of the article, and revised the article. Chih-Hsueh Lin and Cheng-Li Lin conducted the data analysis and revised the article. Kuan-Fu Liao participated in the data interpretation and revised the article.

Compliance with ethical statements

Conflict of interest

The authors disclose no conflicts of interest.

Ethical approval

The study was approved by the Research Ethics Committee of China Medical University and Hospital in Taiwan (CMUH-104-REC2-115).

Informed consent

Insurance reimbursement claims data used in this study were available for public access. Patient identification numbers had been scrambled to ensure confidentiality. Patient informed consent was not required.


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Copyright information

© European Geriatric Medicine Society 2018

Authors and Affiliations

  • Shih-Wei Lai
    • 1
    • 2
  • Chih-Hsueh Lin
    • 1
    • 2
  • Cheng-Li Lin
    • 1
    • 3
  • Kuan-Fu Liao
    • 4
    • 5
  1. 1.College of MedicineChina Medical UniversityTaichungTaiwan
  2. 2.Department of Family MedicineChina Medical University HospitalTaichungTaiwan
  3. 3.Management Office for Health DataChina Medical University HospitalTaichungTaiwan
  4. 4.College of MedicineTzu Chi UniversityHualienTaiwan
  5. 5.Department of Internal MedicineTaichung Tzu Chi General HospitalTaichung CityTaiwan

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