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The synthesis of Aspirin and Acetobromo-α-D-glucose using 3D printed flow reactors: an undergraduate demonstration

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Abstract

The field of flow chemistry is growing rapidly, drawing attention across different disciplines. Despite its increasing popularity in the industry and research, little attention is given to the teaching of flow chemistry in the educational environment, especially at the undergraduate level. A major challenge with teaching undergraduate flow chemistry is the high cost of flow chemistry equipment. This study reports the development of low-cost, functioning flow chemistry equipment for the teaching of flow chemistry and experimental practicum. This provides the students with hands-on instruction in fabricating flow reaction devices by 3D printing. It also allows undergraduate students to understand the basics of flow chemistry and chemical engineering. An exciting part of this study is the skills acquired by undergraduate students. This is because of the learning experience they are exposed to by training and independently operating fabrication equipment, setting up flow experiments and conducting flow experiments with the fabricated devices. Finally, due to the low cost of the equipment, the set-up is suitable for teaching flow chemistry in a low-resource environment, such as our teaching laboratories in South Africa.

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References

  1. Watts P (2015) Continuous flow reactor Technology for Nanomaterial Synthesis. J Biochips Tissue Chips 5:1–3

    Google Scholar 

  2. Watts P, Wiles C (2012) Micro reactors, flow reactors and continuous flow synthesis. J Chem Res 36:181–193

    Article  CAS  Google Scholar 

  3. Blanco-Ania D, Rutjes FPJT (2017) Continuous-flow chemistry in chemical education. J Flow Chem 7:157–158

    Article  CAS  Google Scholar 

  4. Alimi OA, Meijboom R (2021) Current and future trends of additive manufacturing for chemistry applications: a review. J Mater Sci 30:16824–16850

    Article  Google Scholar 

  5. Alimi OA, Bingwa N, Meijboom R (2019) Homemade 3-D printed flow reactors for heterogeneous catalysis. Chem Eng Res Des 150:116–129

    Article  CAS  Google Scholar 

  6. Alimi OA, Ncongwane TB, Meijboom R (2020) Design and fabrication of a monolith catalyst for continuous flow epoxidation of styrene in polypropylene printed flow reactor. Chem Eng Res Des 159:395–409

    Article  CAS  Google Scholar 

  7. Alimi OA, Akinnawo CA, Onisuru OR, Meijboom R (2020) 3-D printed microreactor for continuous flow oxidation of a flavonoid. J Flow Chem 10:517–531

    Article  CAS  Google Scholar 

  8. Onisuru OR, Alimi OA, Potgieter K, Meijboom R (2021) Continuous-flow catalytic degradation of Hexacyanoferrate ion through Electron transfer induction in a 3D-printed flow reactor. J Mater Eng Perform 30:4891–4901

    Article  CAS  Google Scholar 

  9. Alimi OA, Akinnawo CA, Meijboom R (2020) Monolith catalyst design via 3D printing: a reusable support for modern palladium-catalyzed cross-coupling reactions. New J Chem 44:18867–18878

    Article  CAS  Google Scholar 

  10. LaGrow AP, Besong TMD, AlYami NM et al (2017) Trapping shape-controlled nanoparticle nucleation and growth stages via continuous-flow chemistry. Chem Commun 53:2495–2498

    Article  CAS  Google Scholar 

  11. Sambiagio C, Noël T (2020) Flow photochemistry: Shine some light on those tubes! Trends Chem 2:92–106

    Article  CAS  Google Scholar 

  12. Noël T, Cao Y, Laudadio G (2019) The fundamentals behind the use of flow reactors in electrochemistry. Acc Chem Res 52:2858–2869

    Article  Google Scholar 

  13. Pletcher D, Green RA, Brown RCD (2017) Flow electrolysis cells for the synthetic organic chemistry laboratory. Chem Rev 118:4573–4591

    Article  Google Scholar 

  14. König B, Kreitmeier P, Hilgers P, Wirth T (2013) Flow chemistry in undergraduate organic chemistry education. J Chem Educ 90:934–936

    Article  Google Scholar 

  15. Penny MR, Tsui N, Hilton ST (2021) Extending practical flow chemistry into the undergraduate curriculum via the use of a portable low-cost 3D printed continuous flow system. J Flow Chem 11:19–29

    Article  CAS  Google Scholar 

  16. Bannock JH, Krishnadasan SH, Heeney M, de Mello JC (2014) A gentle introduction to the noble art of flow chemistry. Mater Horizons 1:373–378

    Article  CAS  Google Scholar 

  17. Kairouz V, Collins SK (2018) Continuous flow science in an undergraduate teaching laboratory: bleach-mediated oxidation in a biphasic system. J Chem Educ 95:1069–1072

    Article  CAS  Google Scholar 

  18. McMullen JP, Jensen KF (2010) Integrated microreactors for reaction automation: new approaches to reaction development. Annu Rev Anal Chem 3:19–42

    Article  CAS  Google Scholar 

  19. Tundo P, Rosamilia AE, Arico F (2010) Methylation of 2-naphthol using dimethyl carbonate under continuous-flow gas-phase conditions. J Chem Educ 87:1233–1235

    Article  CAS  Google Scholar 

  20. Vangunten MT, Walker UJ, Do HG, Knust KN (2019) 3D-printed microfluidics for hands-on undergraduate laboratory experiments. J Chem Educ 97:178–183

    Article  Google Scholar 

  21. Leibfarth FA, Russell MG, Langley DM et al (2018) Continuous-flow chemistry in undergraduate education: sustainable conversion of reclaimed vegetable oil into biodiesel. J Chem Educ 95:1371–1375

    Article  CAS  Google Scholar 

  22. Price AJN, Capel AJ, Lee RJ et al (2021) An open source toolkit for 3D printed fluidics. J Flow Chem 11:37–51

    Article  CAS  Google Scholar 

  23. Kuijpers KPL, Weggemans WMA, Verwijlen CJA, Noël T (2021) Flow chemistry experiments in the undergraduate teaching laboratory: synthesis of diazo dyes and disulfides. J Flow Chem 11:7–12

    Article  CAS  Google Scholar 

  24. Moore JL, McCuiston A, Mittendorf I et al (2011) Behavior of capillary valves in centrifugal microfluidic devices prepared by three-dimensional printing. Microfluid Nanofluid 10:877–888

    Article  Google Scholar 

  25. Prusa J (2016) 3D printing handbook.User manual for 3D printers :original Prusa i3 MK2 kit 1.75mm

  26. Neumaier JM, Madani A, Klein T, Ziegler T (2019) Low-budget 3D-printed equipment for continuous flow reactions. Beilstein J Org Chem 15:558–566s

    Article  CAS  Google Scholar 

  27. Cline L (2015) 3D printing with Autodesk 123D®, Tinkercad®, and MakerBot®. McGraw-Hill Education, New York

  28. Booeshaghi AS, da Veiga BE, Bannon D et al (2019) Principles of open source bioinstrumentation applied to the poseidon syringe pump system. Sci Rep 9:1–8

    Article  CAS  Google Scholar 

  29. Olmsted III JA (1998) Synthesis of aspirin: a general chemistry experiment. J Chem Educ 75:1261

    Article  CAS  Google Scholar 

  30. Young JC (2013) True melting point determination. Chem Educ 18:203–208

    Google Scholar 

  31. Gundlach M, Paulsen K (2015) Garry M, et al. Yin and Yang in Chemistry Education, The Complementary Nature of FT-IR and NMR Spectroscopies

    Google Scholar 

  32. Barry E, Borer LL (2000) Experiments with aspirin. J Chem Educ 77:354

    Article  Google Scholar 

  33. British Pharmacopoeia Commission (2002) British Pharmacopoeia (Vol. II, pp.780). The stationary office London, UK

  34. Pál M, Janda T, Majláth I, Szalai G (2020) Involvement of salicylic acid and other phenolic compounds in light-dependent cold acclimation in maize. Int J Mol Sci 21:1942

    Article  Google Scholar 

  35. Wang ZD, Mo Y, Chiou C-L, Liu M (2010) A simple preparation of 2, 3, 4, 6-tetra-O-acyl-gluco-, galacto-and mannopyranoses and relevant theoretical study. Molecules 15:374–384

    Article  CAS  Google Scholar 

  36. Gutierrez L, Gomez L, Irusta S et al (2011) Comparative study of the synthesis of silica nanoparticles in micromixer–microreactor and batch reactor systems. Chem Eng J 171:674–683

    Article  CAS  Google Scholar 

Download references

Acknowledgements

The authors are grateful for the financial support from the Teaching and Innovation Fund, University of Johannesburg. Thanks are also extended to the University of Johannesburg Global Excellence Stature (G.E.S.) 4.0 initiative. All undergraduate students who have assisted in this study are acknowledged for their constructive comments and participation. We would also like to thank Mr. D. Harris and Dr. R. Meyer from Shimadzu, South Africa, for the use of their instruments.

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Correspondence to Reinout Meijboom.

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Alimi, O.A., Potgieter, K., Khumalo, A.A. et al. The synthesis of Aspirin and Acetobromo-α-D-glucose using 3D printed flow reactors: an undergraduate demonstration. J Flow Chem 12, 265–274 (2022). https://doi.org/10.1007/s41981-022-00236-y

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