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Voltage-driven microfluidic synthesis of magnetite and gold nanomaterials

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A Correction to this article was published on 16 August 2022

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A low-cost facile synthesis of electronic nanomaterials such as magnetite (Fe3O4), and gold (Au) using polyvinylpyrrolidone (PVP) as a reducing and stabilizing agent in a 3D-printed droplet-based microfluidic device has been demonstrated. The nanomaterial synthesis in terms of obtaining uniformity in size and shape or enhanced magnetism was controlled by applying voltage across the metal electrodes placed just beneath the reagent mixing chamber of the device. The transmission electron microscopy (TEM) characterization showed that application of different alternating current (AC) voltages resulted in different size nanoplate and spherical-shaped Fe3O4 and Au electronic nanomaterials, respectively. A simulation study on accessing the velocity profile of particles within the droplets and transmission probability in AC electric field at different voltages is also demonstrated.

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  1. Whitesides GM (2006) The origins and the future of microfluidics. Nature 442:368–373

    Article  CAS  Google Scholar 

  2. Ren K, Zhou J, Wu H (2013) Materials for Microfluidic Chip Fabrication. Acc Chem Res 46:2396–2406

    Article  CAS  Google Scholar 

  3. Ma J, Lee SM-Y, Yi C, Li C-W (2017) Controllable synthesis of functional nanoparticles by microfluidic platforms for biomedical applications – a review. Lab Chip 17:209–226

    Article  CAS  Google Scholar 

  4. Liu Y, Jiang X (2017) Why microfluidics? Merits and trends in chemical synthesis. Lab Chip 17:3960–3978

    Article  CAS  Google Scholar 

  5. Mornet S, Vasseur S, Grasset F, Duguet E (2004) Magnetic nanoparticle design for medical diagnosis and therapy. J Mater Chem 14:2161–2175

    Article  CAS  Google Scholar 

  6. Lu AH, Salabas E, Schüth F (2007) Magnetic nanoparticles: synthesis, protection, functionalization, and application. Angew Chem 119:1242–1266; Angew Chem Int Ed 46:1222–1244

  7. Singh V, Krishnan S (2015) Voltammetric immunosensor assembled on carbon-pyrenyl nanostructures for clinical diagnosis of type of diabetes. Anal Chem 87:2648–2654

  8. Singh V, Krishnan S (2018) Electrochemical and surface plasmon insulin assays on clinical samples. Analyst 143:1544–1555

  9. Singh V (2021) 3D-printed device for synthesis of magnetic and metallic nanoparticles. J Flow Chem 11:135–142

  10. Song H, Chen DL, Ismagilov RF (2006) Reactions in droplets in microfluidic channels. Angew Chem 118:7494–7516; Angew Chem Int Ed 45:7336–7356

  11. Teh SY, Lin R, Hung LH, Lee AP (2008) Droplet microfluidics. Lab Chip 8:198–220

  12. Ziaei-Azad H, Semagina N (2014) Bimetallic catalysts: Requirements for stabilizing PVP removal depend on the surface composition. Appl Catal A 482:327–335

  13. Si R, Zhang YW, You LP, Yan CH (2006) Self-organized monolayer of nanosized ceria colloids stabilized by poly(vinylpyrrolidone). J Phys Chem B 110:5994–6000

  14. Sun Y, Yin Y, Mayers BT, Herricks T, Xia Y (2002) Uniform silver nanowires synthesis by reducing AgNO3 with ethylene glycol in the presence of seeds and poly(vinylpyrrolidone). Chem Mater 14:4736–4745

  15. Wiley B, Sun Y, Xia Y (2007) Synthesis of silver nanostructures with controlled shapes and properties. Acc Chem Res 40:1067–1076

  16. Kim F, Connor S, Song H, Kuykendall T, Yang P (2004) Platonic gold nanocrystals. Angew Chem Int Ed 43:3673–3677

  17. Pastoriza-Santos I, Liz-Marzán LM (2009) N,N-Dimethylformamide as a reaction medium for metal nanoparticle synthesis. Adv Funct Mater 19:679–688

  18. Zheng Y, Cheng Y, Wang Y, Bao F, Zhou L, Wei X, Zhang Y, Zheng Q (2006) Quasicubic alpha-Fe2O3 nanoparticles with excellent catalytic performance. J Phys Chem B 110:3093–3097

  19. Xia Q, Chen X, Zhao K, Liu J (2008) Synthesis and characterizations of polycrystalline walnut-like CdS nanoparticle by solvothermal method with PVP as stabilizer. Mater Chem Phys 111:98–105

  20. Frenz L, El Harrak A, Pauly M, Bégin-Colin S, Griffiths AD, Baret JC (2008) Droplet-based microreactors for the synthesis of magnetic iron oxide nanoparticles. Angew Chem Int Ed 47:6817–6820

  21. Abalde-Cela S, Taladriz-Blanco P, de Oliveira MG, Abell C (2018) Droplet microfluidics for the highly controlled synthesis of branched gold nanoparticles. Sci Rep 8:2440

  22. Massart R (1981) Preparation of aqueous magnetic liquids in alkaline and acidic media. IEEE Trans Magn 17:1247–1248

  23. Zhou Y, Zhu X, Li S (2015) Effect of particle size on magnetic and electric transport properties of La0.67Sr0.33MnO3 coatings. Phys Chem Chem Phys 17:31161–31169

  24. Mamania JB, Gamarra LF, de Souza Brito GE (2014) Synthesis and characterization of Fe3O4 nanoparticles with perspectives in biomedical applications. Mater Res 17:542–549

  25. Zhu Y, Tao S, Chen C, Liu J, Chen M, Shangguan W (2021) A novel approach for evaluating the effect of external electric field on charged particles based on the Lagrangian particle tracking method. Powder Technol 394:92–102

  26. Yi DK, Selvan ST, Lee SS, Papaefthymiou GC, Kundaliya D, Ying JY (2005) Silica-coated nanocomposites of magnetic nanoparticles and quantum dots. J Am Chem Soc 127:4990–4991

  27. Luo X, Du L, Wen Z, Lv W, Zhao F, Jiang X, Peng Y, Sun L, Li Y, Rao J (2015) Remarkably enhanced red–NIR broad spectral absorption via gold nanoparticles: applications for organic photosensitive diodes. Nanoscale 7:14422–14433

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V.S is grateful to the Department of Science and Technology (DST), Government of India for the financial support under the Women Scientist Scheme (Project Number: SR/WOS-A/ET-46/2018) to carry out this work.

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Correspondence to Vini Singh.

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Singh, V., Singh, R. Voltage-driven microfluidic synthesis of magnetite and gold nanomaterials. J Flow Chem 12, 255–261 (2022).

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