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A facile iron catalyzed cross-coupling reaction under micro-flow conditions

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Abstract

The iron-catalyzed cross-coupling reaction between an aromatic Grignard reagent and a haloalkane was investigated under micro-flow conditions. The reaction proceeded smoothly by the separate feeding of the substrate solutions to give the desired cross-coupling product. Compared to the previously reported batch reaction, the effect of additives was more predominant in the micro-flow reaction. The flow reactor system appears to contribute to the stabilization and rapid trapping of the unstable catalytic species.

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Scheme 1
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Correspondence to Koji Machitani or Hajime Mori.

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Machitani, K., Tanaka, Y., Nishiyama, Y. et al. A facile iron catalyzed cross-coupling reaction under micro-flow conditions. J Flow Chem 10, 491–495 (2020). https://doi.org/10.1007/s41981-020-00091-9

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  • DOI: https://doi.org/10.1007/s41981-020-00091-9

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