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Metallorganic reactions in the polytropic microreactors

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Abstract

High exothermicity, unstable intermediates, high reaction rates are the features that make metallorganic reactions very challenging, especially in commercial operation. No wonder that there is a large interest for the alternative production technology. This paper reviews a research program by Bayer on metallorganic reactions in microreactors. Selected aspects of use of micro-reaction technology for this reaction class are discussed. Two operational issues, i.e. temperature control and clogging are highlighted. Furthermore, the design concept of a MRT based commercial unit and its economics are discussed.

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References

  1. Wolf A, Michele V, Schlüter OF-K, Herbstritt F, Heck J, Mleczko L (2015). Chem Eng Technol 38(11):2017–2024

    Article  CAS  Google Scholar 

  2. Fu M, Luan W, Tu S-T, Mleczko L (2015) J Nanomater 842365/1–842365/9

  3. Lu H, Hoheisel W, Mleczko L, Nowak S Continuous synthesis of high quantum yield InP/ZnS nanocrystals. (2014) EP2785897A1, Oct.

  4. Henig M (2011) Process, 2011. http://www.process-worldwide.com. Accessed 10/20/2010

  5. Buchholz S, Mleczko L (2008). VDI-Ber 2039:177–181

    CAS  Google Scholar 

  6. Ji G, Ding C, Zhang G, Ji S, Ji G, Ji X, Yang H (2014) Method utilizing micro-channel to prepare tris(2-chloroethyl)phosphite. CN104119374A, Oct

  7. Mleczko L, Zhao D (2015) Technology for Continuous Production of Fine Chemicals, A Case Study for Low Temperature Lithiation Reactions. In: Managing Hazardous Reactions and Compounds in Process Chemistry; Pesti, J. A., Abdel-Magid, A. F. (Eds). American Chemical Society: Washington, DC

  8. Tian S, Fu M, Hoheisel W, Mleczko L (2016). Chem Eng J 289:365–373

    Article  CAS  Google Scholar 

  9. Thaisrivongs DA, Naber JR, McMullen JP (2016). Org Process Res Dev 20:1997–2004

    Article  CAS  Google Scholar 

  10. Murray PRD, Browne DL, Pastre JC, Butters C, Guthrie D, Ley SV (2013). Org Process Res Dev 17:1192–1108

    Article  CAS  Google Scholar 

  11. Yoshida J (2009) Flash Chemistry: Fast Organic Synthesis in Microsystems. Wiley:New York,

  12. Kim H, Min K-I, Inoue K, Im DJ, Kim D-P, Yoshida J-i (2016). Science 352:691–694

    Article  CAS  PubMed  Google Scholar 

  13. Yoshida J-i, Takahashi Y, Nagaki A (2013). Chem Commun 49:9896–9904

    Article  CAS  Google Scholar 

  14. Nagaki A, Ichinari D, Yoshida J-i (2014). J Am Chem Soc 136(35):12245–12448

    Article  CAS  PubMed  Google Scholar 

  15. Hafner A, Meisenbach M, Sedelmeier J (2016). Org Lett 18(15):3630–3633

    Article  CAS  PubMed  Google Scholar 

  16. Hafner A, Filipponi P, Piccioni L, Meisenbach M, Schenkel B, Venturoni F, Sedelmeier J (2016). Org Process Res Dev 20:1833–1837

    Article  CAS  Google Scholar 

  17. Laue S, Haverkamp V, Mleczko L (2016). Org Process Res Dev 20:480–486

    Article  CAS  Google Scholar 

  18. Xie D, Zhou J, Tian S, Mleczko L, Zhou X (2016). Chem Eng Technol 39(8):1451–1456

    Article  CAS  Google Scholar 

  19. Laue S, Haverkamp V, Frye M, Michele V, Mleczko L (2007) Process for continuously preparing difluorobenzene derivatives with long operating times. WO2007054213A1, May

  20. Liu T, Yu F (2010) Continuous reacting device and method for strong exothermic reaction. CN101757881A, June

  21. Westermann T, Mleczko L (2016). Org Process Res Dev 20(2):487–494

    Article  CAS  Google Scholar 

  22. Harrington PJ (2011) Pharmaceutical process chemistry for synthesis: rethinking the routes to scale-up. Wiley: New York, pp 304–305

  23. Oppenheimer J Methods of isolating 4-chloro-2-fluoro-3-substituted-phenylboronic acids. (2014) US8822730B2, Sep

  24. Hessel V, Kralisch D, Kockmann N (2015) Novel process windows. Wiley-VCH, Weinheim

    Google Scholar 

  25. Nogaki A, Yoshida J-I (2014) In: Luisi R, Capriati V (eds) Lithium compounds in organic synthesis: from fundamentals to applications. Wiley-VCH, Weinheim

    Google Scholar 

  26. Hunter SM, Susanne F, Whitten R, Hartwig T, Schilling M (2018). Tetrahedron 74:3176–3182

    Article  CAS  Google Scholar 

  27. Haber J, Jiang B, Maeder T, Borhani N, Thome J, Renken A, Kiwi-Minskera L (2014). Chem Eng Process Process Intensif 84:14–23

    Article  CAS  Google Scholar 

  28. Hartman RL (2012). Org Process Res Dev 16(5):870–887

    Article  CAS  Google Scholar 

  29. Flowers BS, Hartman RL (2012). Challenges 3(2):194–211

    Article  Google Scholar 

  30. Hartman RL, Naber JR, Zaborenko N (2010). Org Process Res Dev 14(6):1347–1357

    Article  CAS  Google Scholar 

  31. Stubblefield CB, Bach RO (1972). J Chem Eng Data 17(4):491–492

    Article  CAS  Google Scholar 

  32. Wynn DA, Roth MM, Pollard BD (1984). Talanta 31(11):1036–1040

    Article  CAS  PubMed  Google Scholar 

  33. Jennifer J (2010) PhD thesis, Universite Francois-Rabelais de Tours

  34. Jensen KF (2017). AICHE J 63(3):858–869

    Article  CAS  Google Scholar 

  35. Poechlauer P, Colberg J, Fisher E, Jansen M, Johnson MD, Koenig SG, Lawler M, Laporte T, Manley J, Martin B, O’Kearney-McMullan A (2013). Org Process Res Dev 17:1472–1478

    Article  CAS  Google Scholar 

  36. Roberge DM, Ducry L, Bieler N, Cretton P, Zimmermann B (2005). Chem Eng Technol 28(3):318–323

    Article  CAS  Google Scholar 

  37. Roberge DM, Zimmermann B, Rainone F, Gottsponer M, Eyholzer M, Kockmann N (2008). Org Process Res Dev 12:905–910

    Article  CAS  Google Scholar 

  38. Krtschila U, Hessel V, Kralischd D, Kreiseld G, Küpperb M, Schenkb R (2006). Chimia 60:611–617

    Article  CAS  Google Scholar 

Download references

Acknowledgments

In this paper we summarized results obtained over the long time by a large team of colleagues. We can’t name them all but we would like to thank explicitly Dres S. Peper who analyzed the solubility of Li-salts, T. Westermann who studied temperature control and Shizhe Tian who dealt with economic evaluation.

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Authors and Affiliations

  1. Process Technology & Scouting, Engineering and Technology, Bayer (China) Ltd., Shanghai, 201507, China

    Min Fu

  2. Division of Process Technology Development, Engineering and Technology, Bayer GmbH, 51368, Leverkusen, Germany

    Leslaw Mleczko

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  1. Min Fu
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  2. Leslaw Mleczko
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Correspondence to Leslaw Mleczko.

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Fu, M., Mleczko, L. Metallorganic reactions in the polytropic microreactors. J Flow Chem 9, 89–100 (2019). https://doi.org/10.1007/s41981-019-00030-3

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  • DOI: https://doi.org/10.1007/s41981-019-00030-3

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