Journal of Flow Chemistry

, Volume 8, Issue 2, pp 81–88 | Cite as

Reductive aminations using a 3D printed supported metal(0) catalyst system

  • Charlotte Genet
  • Xuan Nguyen
  • Bita Bayatsarmadi
  • Mike D. Horne
  • James Gardiner
  • Christian H. HornungEmail author
Full Paper


Additively manufactured catalytic static mixers were used for the intensified reductive amination of aldehydes and ketones inside a continuous flow reactor. This efficient synthesis method is enabled by the use of tubular reactors fitted with 3D printed metal static mixers which are coated with a catalytically active layer, either Pd or Ni. The 3D printing process allows for maximum design flexibility for the mixer scaffold and is compatible with a range of deposition methods including electroplating and metal cold spraying. Single- and multi-stage continuous flow processing yielded high to full conversion and has the potential to scale-up these operations without the need for manual handling of reactive imine intermediates.

The continuous flow reductive amination was performed in a tubular hydrogenation reactor, using nickel or palladium containing catalytic static mixers

Graphical Abstract


Heterogeneous catalysis Flow chemistry Hydrogenation Amines Palladium Nickel 



The authors thank Winston Liew for ICP-OES measurements, Andrew Urban for cold-spraying of the nickel catalyst, Darren Fraser for 3D printing of the mixer substrates, John Tsanaktsidis, Oliver Hutt and Dayalan Gunasegaram for many helpful discussions and the Active Integrated Matter (AIM) Future Science Platform for financial support for Charlotte Genet.

Supplementary material

41981_2018_13_MOESM1_ESM.docx (4 mb)
ESM 1 (DOCX 4122 kb)


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Copyright information

© Akadémiai Kiadó 2018

Authors and Affiliations

  • Charlotte Genet
    • 1
  • Xuan Nguyen
    • 1
  • Bita Bayatsarmadi
    • 2
  • Mike D. Horne
    • 2
  • James Gardiner
    • 1
  • Christian H. Hornung
    • 1
    Email author
  1. 1.CSIRO ManufacturingClayton SouthAustralia
  2. 2.CSIRO Minerals ResourcesClayton SouthAustralia

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