Das Syndrom polyzystischer Ovarien und Metformin

Polycystic ovary syndrome and metformin

Zusammenfassung

Das Syndrom polyzystischer Ovarien (PCOS) gilt als die häufigste endokrine Erkrankung bei Frauen mit Kinderwunsch und ist ein klinisches Syndrom mit unterschiedlichen phänotypischen Ausprägungen. Bei PCOS gibt es kein einzelnes diagnostisches Kriterium für die klinische Diagnostik, sondern meist besteht eine Kombination mehrerer klinischer Symptome. Eine kausale Behandlung ist wegen des fehlenden Wissens der Pathogenese des PCOS derzeit nicht möglich. Obwohl noch nicht ausreichend klinische Evidenz mit Studien vorliegt, erscheint der wichtigste therapeutische Ansatz bei PCOS eine Lebensstilmodifikation mit ausgewogener Mischkost und Steigerung der körperlichen Aktivität zu sein. In diesem Manuskript beschreiben wir, warum Lebensstilmodifikation als Grundlage der Therapie bei PCOS erscheint und das antidiabetische Medikament Metformin nur als eine begleitende Therapie zu dieser Lebensstilmodifikation gelten sollte.

Abstract

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women who want to have children and is a clinical syndrome with variable phenotypic characteristics. In PCOS there is no single diagnostic criterion for clinical diagnosis, but there is usually a combination of several clinical symptoms. Because of the lack of knowledge of the pathogenesis in PCOS a causal treatment is currently not available. Although there is so far not enough clinical evidence available based on scientific studies, the most important therapeutic approach in PCOS seems to be life style modification with a balanced diet and increased physical activity. In this manuscript we describe why life style modification seems to be the basis of therapy in PCOS, and that the antidiabetic drug metformin should only be considered as an adjunctive therapy to this life style modification.

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Corresponding author

Correspondence to Univ.-Prof. Dr. Wolfgang J. Schnedl.

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Interessenkonflikt

W.J. Schnedl und M. Schenk geben an, dass kein Interessenkonflikt besteht.

Dieser Beitrag beinhaltet keine von den Autoren durchgeführten Studien an Menschen oder Tieren.

Additional information

Teile dieser Übersichtsarbeit wurden bei der gemeinsamen Jahrestagung der Österreichischen Gesellschaft für Reproduktionsmedizin und Endokrinologie und der Österreichischen IVF-Gesellschaft am 28. September 2017, Schloss Seggau, Österreich, präsentiert.

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Schnedl, W.J., Schenk, M. Das Syndrom polyzystischer Ovarien und Metformin. J. Gynäkol. Endokrinol. 28, 10–13 (2018). https://doi.org/10.1007/s41974-018-0034-z

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Schlüsselwörter

  • Syndrom polyzystischer Ovarien
  • Metabolisches Syndrom
  • Diabetes mellitus Typ 2
  • Metformin
  • Gestationsdiabetes

Keywords

  • Polycystic ovary syndrome
  • Metabolic syndrome
  • Diabetes mellitus, type 2
  • Metformin
  • Gestational diabetes