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From biopolymer duplication to membrane duplication and beyond


The relationship between biopolymer duplication and membranes compartmentation is analyzed, by stressing their intertwinement and the different monomers that determine their forms of aggregation (linear and circular) with their functions. Both polymers and membranes are prebiotic forms of molecular assemblies, but in their integration the seed of life emerges. From membranes hosting a replicative metabolism cells stem as living unities, where an almost perfect synthesis is realized between metabolism and duplication. What is missing to perfection becomes the basis of evolution. The whole logic of the processes at the origin of life is reconstructed in general terms, in the line of Manca (Infobiotics: information in biotic systems. Springer, New York, 2013), Manca (J Proteom Bioinform 11(7), 135–137, 2018) and Manca and Santagata (Un meraviglioso accidente. La nascita della vita. Mondadori, Italy, 2018), with no biochemistry detail, but only on the basis of the needs for representing, conserving, developing, and transmitting biological information.

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Correspondence to Vincenzo Manca.

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Paper presented as invited talk at CMC 20, August 5–8, 2019, Curtea de Arges, Romania.

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Manca, V. From biopolymer duplication to membrane duplication and beyond. J Membr Comput 1, 292–303 (2019).

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  • Monomers
  • Biopolymers
  • Membranes
  • Aggregation
  • Duplication
  • Replication
  • Generation
  • Reproduction
  • Proto-genomes
  • Proto-cells