Journal of the Australian Ceramic Society

, Volume 53, Issue 1, pp 217–223 | Cite as

Part 2: biocompatibility evaluation of hydroxyapatite-based clinoptilolite and Al2O3 composites

  • C. KalkandelenEmail author
  • M. Suleymanoglu
  • S. E. Kuruca
  • A. Akan
  • F.N. Oktar
  • O. Gunduz


The biocompatibility of clinoptilolite/alumina/bovine hydroxyapatite (Cp - A12O3 - BHA) composite, at different ratio obtained by powder pressing process, were investigated studying the behavior of osteosarcoma (SAOS-2) cells. The biocompatibility was examined by means of cytotoxicity and cytocompatibility tests. The structure and morphology of bioceramic composites were studied by scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR) technique. The results showed that these materials have no toxic effects. The natural composite that fabricated in this study may be a promising approach for bone-engineering applications.


Bovine hydroxyapatite Clinoptilolite Alumina Biocomposites Biocompatibility 



This study was supported by Istanbul University, Scientific Research Projects Coordination Unit, Project No: 29071.


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Copyright information

© Australian Ceramic Society 2017

Authors and Affiliations

  • C. Kalkandelen
    • 1
    • 2
    Email author
  • M. Suleymanoglu
    • 3
  • S. E. Kuruca
    • 3
  • A. Akan
    • 4
    • 1
  • F.N. Oktar
    • 5
    • 6
  • O. Gunduz
    • 7
    • 6
  1. 1.Biomedical Engineering, Ph.D. Program, Institute of Graduate Studies in Science and EngineeringIstanbul UniversityIstanbulTurkey
  2. 2.Vocational School of Technical Sciences, Biomedical Devices Technology DepartmentIstanbul UniversityIstanbulTurkey
  3. 3.Istanbul Faculty of PhysiologyIstanbul UniversityIstanbulTurkey
  4. 4.Department of Biomedical Engineering, Faculty of Engineering and ArchitectureIzmir Katip Celebi UniversityIzmirTurkey
  5. 5.Department of Bioengineering, Faculty of EngineeringMarmara UniversityIstanbulTurkey
  6. 6.Advanced Nanomaterials Research LaboratoryMarmara UniversityIstanbulTurkey
  7. 7.Department of Metallurgy and Materials Engineering, Faculty of TechnologyMarmara UniversityIstanbulTurkey

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