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Role of Actin Cytoskeleton in E-cadherin-Based Cell–Cell Adhesion Assembly and Maintenance

Journal of the Indian Institute of Science volume 101, pages 51–62 (2021)Cite this article

Abstract

The cellular cytoskeleton consisting of microtubules, intermediate filaments and the actin filaments is a dynamic structure providing shape and structural stability to cells. Particularly, the actin cytoskeleton formed by a combination of polymerized actin molecules and several other actin binding proteins including myosin is key to sensing and development of mechanical forces in cells. Given this and other features, the actin cytoskeleton has been implicated in a variety of cellular process including cellular motility and migration, cytokinesis, phagocytosis, cytoplasmic streaming, organelle transport, cellular transformation and metastasis, cellular metabolism, cell–matrix adhesion, and cell–cell adhesion. The latter is mediated by E-cadherin in the epithelial tissue and is fundamental to tissue morphogenesis and normal development. Here we discuss the role of the actin cytoskeleton in the assembly and maintenance of E-cadherin-based cell–cell adhesion through the formation of cellular appendages such as filopodia and lamellipodia and thus, impinging on one of the fundamental features of multicellular organisms.

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Acknowledgements

This work is supported by an internal funding from the College of Health & Life Sciences, Hamad Bin Khalifa University, a member of the Qatar Foundation. A.M.G. and S.R. are supported by a postdoctoral fellowship and scholarship from the College of Health & Life Sciences, Hamad Bin Khalifa University, a member of the Qatar Foundation, respectively.

Funding

This work is supported by an internal funding from the College of Health & Life Sciences, Hamad Bin Khalifa University, a member of the Qatar Foundation. A.M.G. and S.R. are supported by a postdoctoral fellowship and scholarship from the College of Health & Life Sciences, Hamad Bin Khalifa University, a member of the Qatar Foundation, respectively.

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  1. Saad Rasool and Anupriya M. Geethakumari Equal contribution.

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  1. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar

    Saad Rasool, Anupriya M. Geethakumari & Kabir H. Biswas

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K.H.B. conceived the article and prepared the figures. All authors contributed in writing the article.

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Rasool, S., Geethakumari, A.M. & Biswas, K.H. Role of Actin Cytoskeleton in E-cadherin-Based Cell–Cell Adhesion Assembly and Maintenance. J Indian Inst Sci 101, 51–62 (2021). https://doi.org/10.1007/s41745-020-00214-0

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Keywords

  • Actomyosin
  • Adhesion
  • Cadherin
  • Cytoskeleton
  • Filopodia
  • Lamellipodia