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Guess What?

Towards Understanding Autism from Structured Video Using Facial Affect

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Abstract

Autism Spectrum Disorder (ASD) is a condition affecting an estimated 1 in 59 children in the United States. Due to delays in diagnosis and imbalances in coverage, it is necessary to develop new methods of care delivery that can appropriately empower children and caregivers by capitalizing on mobile tools and wearable devices for use outside of clinical settings. In this paper, we present a mobile charades-style game, Guess What?, used for the acquisition of structured video from children with ASD for behavioral disease research. We then apply face tracking and emotion recognition algorithms to videos acquired through Guess What? game play. By analyzing facial affect in response to various prompts, we demonstrate that engagement and facial affect can be quantified and measured using real-time image processing algorithms: an important first-step for future therapies, at-home screenings, and outcome measures based on home video. Our study of eight subjects demonstrates the efficacy of this system for deriving highly emotive structured video from children with ASD through an engaging gamified mobile platform, while revealing the most efficacious prompts and categories for producing diverse emotion in participants.

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Funding

This study was supported by awards to D.P.W. by the National Institutes of Health (1R21HD091500-01 and 1R01EB025025-01). Additionally, we acknowledge support to D.P.W. from the Hartwell Foundation, the David and Lucile Packard Foundation Special Projects Grant, Beckman Center for Molecular and Genetic Medicine, Coulter Endowment Translational Research Grant, Berry Fellowship, Child Health Research Institute, Spectrum Pilot Program, and Thrasher Research Fund. The Dekeyser and Friends Foundation, the Mosbacher Family Fund for Autism Research, and Peter Sullivan provided additional funding.

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Correspondence to Haik Kalantarian.

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Kalantarian, H., Washington, P., Schwartz, J. et al. Guess What?. J Healthc Inform Res 3, 43–66 (2019). https://doi.org/10.1007/s41666-018-0034-9

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