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Multifunctional Peptide-Melanin Hybrid Nanodots with Robust Anti-Cutaneous Photoaging Activity

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Abstract

Skin aging is a systematic and complex process, mainly including intrinsic aging caused by time change and extrinsic aging caused by environmental factors. Photoaging caused by ultraviolet (UV) irradiation is the principle extrinsic factor of skin aging, which can directly or indirectly cause damage to DNA and other biomolecules, generate reactive oxygen species (ROS), and induce a decrease in collagen synthesis and other adverse effect. Herein, to address the causative factors and multiple side effects of skin photoaging, we constructed multifunctional peptide-melanin hybrid nanodots (PMHDs) to achieve multifaceted synergistic anti-skin aging by using melanin-like nanodots (MDs) and functional peptides as active motifs. Among them, the peptide has the activity of promoting collagen synthesis, while the MDs have the function of absorbing UV light and scavenging free radicals. Additionally, the MDs also act as a carrier to increase the cellular uptake of the peptide. The anti-photoaging effects of the PMHDs were systematically verified in a multidimensional manner at the biochemical, cellular and small animal levels, respectively.

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Availability of Data and Materials

The data and materials in current study are available from the corresponding author on reasonable request.

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Funding

This work is financially supported by National Natural Science Foundation of China (NSFC) (22007083); Wenzhou Major Science and Technology Innovation Project (ZZN2023002); the Fundamental Research Funds of Shengzhou Innovation Research Institute of Zhejiang Sci-Tech University (SYY2023B000004); the Fundamental Research Funds of Zhejiang Sci-Tech University (24262132-Y).

Author information

Author notes

  1. Peizhe Li and Qiming Zhu have contributed equally.

Authors and Affiliations

  1. Key Laboratory of Surface & Interface Science of Polymer Materials of Zhejiang Province, School of Chemistry and Chemical Engineering, Zhejiang Sci-Tech University, Hangzhou, 310018, China

    Peizhe Li, Qiming Zhu, Baozhu Wang, Yongmiao Shen & Zhijun Zhang

  2. College of Textile Science and Engineering (International Silk Institute), Zhejiang Sci-Tech University, Hangzhou, 310018, China

    Shanshan He & Miao Su

  3. Shanghai Beautyart Biotechnology Co., Ltd, Shanghai, 200438, China

    Qi Xu & Kaiyan Li

  4. Shengzhou Innovation Research Institute of Zhejiang Sci-Tech University, Shengzhou, 312400, China

    Yongmiao Shen & Zhijun Zhang

Authors
  1. Peizhe Li
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  2. Qiming Zhu
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  3. Baozhu Wang
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  4. Shanshan He
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  5. Qi Xu
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  6. Kaiyan Li
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  7. Yongmiao Shen
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  8. Miao Su
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  9. Zhijun Zhang
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Corresponding author

Correspondence to Zhijun Zhang.

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The authors have no relevant financial or non-financial interests to disclose.

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Cite this article

Li, P., Zhu, Q., Wang, B. et al. Multifunctional Peptide-Melanin Hybrid Nanodots with Robust Anti-Cutaneous Photoaging Activity. J. Anal. Test. (2024). https://doi.org/10.1007/s41664-024-00311-4

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  • DOI: https://doi.org/10.1007/s41664-024-00311-4

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