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Optimization of the Procedure for Gram Scale Synthesis of Silicon Rhodamine and its Application in Labeling BRD4 Kinase Inhibitor

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Scheme 1
Scheme 2
Fig. 1
Fig. 2

Data availability

The data that support the findings of this study are available from the corresponding authors Wei Ren, Sijin Yang and Zengjin Liu, upon reasonable request.

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Acknowledgements

This research was funded by the Sichuan Science and Technology Program ( 24NSFSC5985, 2022YFS0635), the Innovation Team and Talents Cultivation Program of the National Administration of Traditional Chinese Medicine (ZYYCXTD-C-202207), the Luzhou Science and Technology Program (2022-SYF-38, 2020-JYJ-51), university-level project of Southwest Medical University (2021ZKQN118), Joint project of Southwest Medical University and Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University (2020XYLH-016) and the Innovation Team of Sichuan Provincial Administration of Traditional Chinese Medicine (2022C007). Thanks for the experiment conditions provided by Luzhou Key Laboratory for Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases with Integrated Traditional Chinese and Western Medicine and the High-resolution Mass Spectrometry Testing Center of the Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University.

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Author notes

  1. Yanan Zhou, Tao Bi and Raoqiong Wang contributed equally to this work.

Authors and Affiliations

  1. National Traditional Chinese Medicine Clinical Research Base and Drug Research Center of Integrated Traditional Chinese and Western Medicine, the Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, 646000, China

    Yanan Zhou, Tao Bi, Pan Liang, Hong Wang, Hongping Shen, Zengjin Liu, Sijin Yang & Wei Ren

  2. Institute of Integrated Chinese and Western Medicine, Southwest Medical University, Luzhou, 646000, China

    Yanan Zhou, Tao Bi, Pan Liang, Hong Wang, Hongping Shen, Zengjin Liu, Sijin Yang & Wei Ren

  3. Department of Urology, the Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, 646000, China

    Junyu Lai

  4. Department of Sports Physiotherapy, College of Physical Education, Southwest Medical University, Luzhou, 646000, China

    Qiang Luo

  5. State Key Laboratory of Quality Research in Chinese Medicines, Guangdong-Hong Kong-Macao Joint Laboratory of Respiratory Infectious Disease, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Macau, 999078, China

    Raoqiong Wang

Authors
  1. Yanan Zhou
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  2. Tao Bi
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  11. Wei Ren
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Corresponding authors

Correspondence to Zengjin Liu, Sijin Yang or Wei Ren.

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The authors declare that they have no competing financial interests.

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Zhou, Y., Bi, T., Wang, R. et al. Optimization of the Procedure for Gram Scale Synthesis of Silicon Rhodamine and its Application in Labeling BRD4 Kinase Inhibitor. J. Anal. Test. (2024). https://doi.org/10.1007/s41664-024-00309-y

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