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Disruption of Neurosynaptic Physiology and Neuron Network Dysfunction in Brain Disorders: an Environmental and Occupational Health Perspective

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Activitas Nervosa Superior

Abstract

Signaling molecules are subject to impact of numerous products of risk genes and varied environmental insults. Networks of signaling cascades regulate new synaptic transmission and morphology. Pollutants may impact brain through cellular, molecular, and inflammatory pathways, causing direct damage or predisposing to damage by other insults, leading to diseases. Disruptions in structure and function of neurotransmission elements and protein networks contribute to pathogenesis of neuropsychiatric diseases. Different affected brain regions and/or synaptic connections between excitatory and inhibitory neurons characterize different specific clinical states. Identification of the functioning of synaptic signaling networks and specific neuronal pathways would facilitate identification of specific pathomechanisms with implications for preventive and corrective interventions. The present article attempts to garner greater emphasis in contemporary medical teaching, awareness, and preparedness for meeting the mounting health care challenge of pollution-inflicted disruption of neurophysiology and associated brain dysfunction and diseases.

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References

  • Achard, S., Bassett, D. S., Meyer-Lindenberg, A., & Bullmore, E. (2008). Fractal connectivity of long-memory networks. Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics, 77(3 Pt 2), 036104.

    Article  PubMed  Google Scholar 

  • Aertsen, A. M., Gerstein, G. L., Habib, M. K., & Palm, G. (1989). Dynamics of neuronal firing correlation: modulation of "effective connectivity". Journal of Neurophysiology, 61(5), 900–917.

    PubMed  Google Scholar 

  • Allan, S. M., & Rothwell, N. J. (2001). Cytokines and acute neurodegeneration. Nature Reviews. Neuroscience, 2(10), 734–744.

    Article  PubMed  Google Scholar 

  • Allman, J. M., Watson, K. K., Tetreault, N. A., & Hakeem, A. Y. (2005). Intuition and autism: a possible role for von Economo neurons. Trends in Cognitive Sciences, 9(8), 367–373.

    Article  PubMed  Google Scholar 

  • Alloisio, S., Nobile, M., & Novellino, A. (2015). Multiparametric characterisation of neuronal network activity for in vitro agrochemical neurotoxicity assessment. Neurotoxicology, 48, 152–165.

    Article  PubMed  Google Scholar 

  • Ashok, A., Rai, N. K., Tripathi, S., & Bandyopadhyay, S. (2015). Exposure to As-, Cd-, and Pb-mixture induces Aβ, amyloidogenic APP processing and cognitive impairments via oxidative stress-dependent neuroinflammation in young rats. Toxicological Sciences, 143(1), 64–80.

    Article  PubMed  Google Scholar 

  • Avital, A., Goshen, I., Kamsler, A., Segal, M., Iverfeldt, K., Richter-Levin, G., & Yirmiya, R. (2003). Impaired interleukin-1 signaling is associated with deficits in hippocampal memory processes and neural plasticity. Hippocampus, 13(7), 826–834.

    Article  PubMed  Google Scholar 

  • Bains, J. S., & Oliet, S. H. (2007). Glia: they make your memories stick! Trends in Neurosciences, 30(8), 417–424.

    Article  PubMed  Google Scholar 

  • Bartolomei, F., Bosma, I., Klein, M., Baayen, J. C., Reijneveld, J. C., Postma, T. J., et al. (2006). Disturbed functional connectivity in brain tumour patients: evaluation by graph analysis of synchronization matrices. Clinical Neurophysiology, 117(9), 2039–2049.

    Article  PubMed  Google Scholar 

  • Barttfeld, P., Wicker, B., Cukier, S., Navarta, S., Lew, S., & Sigman, M. (2011). A big-world network in ASD: dynamical connectivity analysis reflects a deficit in long-range connections and an excess of short-range connections. Neuropsychologia, 49(2), 254–263.

    Article  PubMed  Google Scholar 

  • Bassett, D. S., & Bullmore, E. (2006). Small-world brain networks. The Neuroscientist, 12(6), 512–523.

    Article  PubMed  Google Scholar 

  • Bassett, D. S., & Bullmore, E. T. (2009). Human brain networks in health and disease. Current Opinion in Neurology, 22(4), 340–347.

    Article  PubMed  PubMed Central  Google Scholar 

  • Bassett, D. S., Bullmore, E., Verchinski, B. A., Mattay, V. S., Weinberger, D. R., & Meyer-Lindenberg, A. (2008). Hierarchical organization of human cortical networks in health and schizophrenia. The Journal of Neuroscience, 28(37), 9239–9248.

    Article  PubMed  PubMed Central  Google Scholar 

  • Beattie, E. C., Stellwagen, D., Morishita, W., Bresnahan, J. C., Ha, B. K., Von Zastrow, M., Beattie, M. S., & Malenka, R. C. (2002). Control of synaptic strength by glial TNFalpha. Science, 295(5563), 2282–2285.

    Article  PubMed  Google Scholar 

  • Becker, L. E. (1991). Synaptic dysgenesis. The Canadian Journal of Neurological Sciences, 18(2), 170–180.

    Article  PubMed  Google Scholar 

  • Beddington, J., Cooper, C. L., Field, J., Goswami, U., Huppert, F. A., Jenkins, R., et al. (2008). The mental wealth of nations. Nature, 455(7216), 1057–1060.

    Article  PubMed  Google Scholar 

  • Bettencourt, L. M., Stephens, G. J., Ham, M. I., & Gross, G. W. (2007). Functional structure of cortical neuronal networks grown in vitro. Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics, 75(2 Pt 1), 021915.

    Article  PubMed  Google Scholar 

  • Bezzi, P., Carmignoto, G., Pasti, L., Vesce, S., Rossi, D., Rizzini, B. L., Pozzan, T., & Volterra, A. (1998). Prostaglandins stimulate calcium-dependent glutamate release in astrocytes. Nature, 391(6664), 281–285.

    Article  PubMed  Google Scholar 

  • Bezzi, P., Domercq, M., Vesce, S., & Volterra, A. (2001). Neuron-astrocyte cross-talk during synaptic transmission: physiological and neuropathological implications. Progress in Brain Research, 132, 255–265.

    Article  PubMed  Google Scholar 

  • Bhattacharjee, S., Zhao, Y., Hill, J. M., Percy, M. E., & Lukiw, W. J. (2014). Aluminum and its potential contribution to Alzheimer's disease (AD). Frontiers in Aging Neuroscience, 6, 62. doi:10.3389/fnagi.2014.00062.

    PubMed  PubMed Central  Google Scholar 

  • Blanpied, T. A., & Ehlers, M. D. (2004). Microanatomy of dendritic spines: emerging principles of synaptic pathology in psychiatric and neurological disease. Biological Psychiatry, 55(12), 1121–1127.

    Article  PubMed  Google Scholar 

  • Block, M. L., & Calderón-Garcidueñas, L. (2009). Air pollution: mechanisms of neuroinflammation and CNS disease. Trends in Neurosciences, 32(9), 506–516.

    Article  PubMed  PubMed Central  Google Scholar 

  • Boersma, M., Smit, D. J., de Bie, H. M., Van Baal, G. C., Boomsma, D. I., de Geus, E. J., et al. (2011). Network analysis of resting state EEG in the developing young brain: structure comes with maturation. Human Brain Mapping, 32(3), 413–425.

    Article  PubMed  Google Scholar 

  • Bolognin, S., Messori, L., & Zatta, P. (2009). Metal ion physiopathology in neurodegenerative disorders. Neuromolecular Medicine, 11(4), 223–238.

    Article  PubMed  Google Scholar 

  • Bosboom, J. L., Stoffers, D., Wolters, E. C., Stam, C. J., & Berendse, H. W. (2009). MEG resting state functional connectivity in Parkinson's disease related dementia. Journal of Neural Transmission, 116(2), 193–202.

    Article  PubMed  Google Scholar 

  • Bosma, G. P., Steens, S. C., Petropoulos, H., Admiraal-Behloul, F., van den Haak, A., Doornbos, J., et al. (2004). Multisequence magnetic resonance imaging study of neuropsychiatric systemic lupus erythematosus. Arthritis and Rheumatism, 50(10), 3195–3202.

    Article  PubMed  Google Scholar 

  • Boulanger, L. M. (2004). MHC class I in activity-dependent structural and functional plasticity. Neuron Glia Biology, 1(3), 283–289.

    Article  PubMed  PubMed Central  Google Scholar 

  • Broyd, S. J., Demanuele, C., Debener, S., Helps, S. K., James, C. J., & Sonuga-Barke, E. J. (2009). Default-mode brain dysfunction in mental disorders: a systematic review. Neuroscience and Biobehavioral Reviews, 33(3), 279–296.

    Article  PubMed  Google Scholar 

  • Calabresi, P., Picconi, B., Tozzi, A., & Di Filippo, M. (2007). Dopamine-mediated regulation of corticostriatal synaptic plasticity. Trends in Neurosciences, 30(5), 211–219.

    Article  PubMed  Google Scholar 

  • Calderón-Garcidueñas, L., Reed, W., Maronpot, R. R., Henríquez-Roldán, C., Delgado-Chavez, R., Calderón-Garcidueñas, A., et al. (2004). Brain inflammation and Alzheimer's-like pathology in individuals exposed to severe air pollution. Toxicologic Pathology, 32(6), 650–658.

    Article  PubMed  Google Scholar 

  • Calderón-Garcidueñas, L., Mora-Tiscareño, A., Ontiveros, E., Gómez-Garza, G., Barragán-Mejía, G., Broadway, J., et al. (2008a). Air pollution, cognitive deficits and brain abnormalities: a pilot study with children and dogs. Brain and Cognition, 68(2), 117–127.

    Article  PubMed  Google Scholar 

  • Calderón-Garcidueñas, L., Solt, A. C., Henríquez-Roldán, C., Torres-Jardón, R., Nuse, B., Herritt, L., et al. (2008b). Long-term air pollution exposure is associated with neuroinflammation, an altered innate immune response, disruption of the blood-brain barrier, ultrafine particulate deposition, and accumulation of amyloid beta-42 and alpha-synuclein in children and young adults. Toxicologic Pathology, 36(2), 289–310.

    Article  PubMed  Google Scholar 

  • Calderón-Garcidueñas, L., Engle, R., Mora-Tiscareño, A., Styner, M., Gómez-Garza, G., Zhu, H., et al. (2011). Exposure to severe urban air pollution influences cognitive outcomes, brain volume and systemic inflammation in clinically healthy children. Brain and Cognition, 77(3), 345–355.

    Article  PubMed  Google Scholar 

  • Campbell, A., Araujo, J. A., Li, H., Sioutas, C., & Kleinman, M. (2009). Particulate matter induced enhancement of inflammatory markers in the brains of apolipoprotein E knockout mice. Journal of Nanoscience and Nanotechnology, 9(8), 5099–5104.

    Article  PubMed  Google Scholar 

  • Caspi, A., McClay, J., Moffitt, T. E., Mill, J., Martin, J., Craig, I. W., Taylor, A., & Poulton, R. (2002). Role of genotype in the cycle of violence in maltreated children. Science, 297(5582), 851–854.

    Article  PubMed  Google Scholar 

  • Chen, J. C., & Schwartz, J. (2009). Neurobehavioral effects of ambient air pollution on cognitive performance in US adults. Neurotoxicology, 30(2), 231–239.

    Article  PubMed  Google Scholar 

  • Chen, S., Le, W. D., Xie, W. J., Alexianu, M. E., Engelhardt, J. I., Siklós, L., & Appel, S. H. (1998). Experimental destruction of substantia nigra initiated by Parkinson disease immunoglobulins. Archives of Neurology, 55(8), 1075–1080.

    Article  PubMed  Google Scholar 

  • Chen, C., Magee, J. C., & Bazan, N. G. (2002). Cyclooxygenase-2 regulates prostaglandin E2 signaling in hippocampal long-term synaptic plasticity. Journal of Neurophysiology, 87(6), 2851–2857.

    PubMed  Google Scholar 

  • Chen, Z. J., He, Y., Rosa-Neto, P., Germann, J., & Evans, A. C. (2008). Revealing modular architecture of human brain structural networks by using cortical thickness from MRI. Cerebral Cortex, 18(10), 2374–2381.

    Article  PubMed  PubMed Central  Google Scholar 

  • Collins, A. R. (2004). The comet assay for DNA damage and repair: principles, applications, and limitations. Molecular Biotechnology, 26(3), 249–261.

    Article  PubMed  Google Scholar 

  • Cory-Slechta, D. A. (2005). Studying toxicants as single chemicals: does this strategy adequately identify neurotoxic risk? Neurotoxicology, 26(4), 491–510.

    Article  PubMed  Google Scholar 

  • Cunningham, C., Campion, S., Lunnon, K., Murray, C. L., Woods, J. F., Deacon, R. M., et al. (2009). Systemic inflammation induces acute behavioral and cognitive changes and accelerates neurodegenerative disease. Biological Psychiatry, 65(4), 304–312.

    Article  PubMed  PubMed Central  Google Scholar 

  • Damoiseaux, J. S., & Greicius, M. D. (2009). Greater than the sum of its parts: a review of studies combining structural connectivity and resting-state functional connectivity. Brain Structure & Function, 213(6), 525–533.

    Article  Google Scholar 

  • Dantzer, R., O'Connor, J. C., Freund, G. G., Johnson, R. W., & Kelley, K. W. (2008). From inflammation to sickness and depression: when the immune system subjugates the brain. Nature Reviews. Neuroscience, 9(1), 46–56.

    Article  PubMed  PubMed Central  Google Scholar 

  • de Haan, W., Pijnenburg, Y. A., Strijers, R. L., van der Made, Y., van der Flier, W. M., Scheltens, P., & Stam, C. J. (2009). Functional neural network analysis in frontotemporal dementia and Alzheimer's disease using EEG and graph theory. BMC Neuroscience, 10, 101. doi:10.1186/1471-2202-10-101.

    Article  PubMed  PubMed Central  Google Scholar 

  • De Vico, F. F., Astolfi, L., Cincotti, F., Mattia, D., Marciani, M. G., Tocci, A., et al. (2008). Cortical network dynamics during foot movements. Neuroinformatics, 6(1), 23–34.

    Article  Google Scholar 

  • Dehaene, S., & Changeux, J. P. (2011). Experimental and theoretical approaches to conscious processing. Neuron, 70(2), 200–227.

    Article  PubMed  Google Scholar 

  • Delbeuck, X., Van der Linden, M., & Collette, F. (2003). Alzheimer's disease as a disconnection syndrome? Neuropsychology Review, 13(2), 79–92.

    Article  PubMed  Google Scholar 

  • Dhillon, A. S., Tarbutton, G. L., Levin, J. L., Plotkin, G. M., Lowry, L. K., Nalbone, J. T., & Shepherd, S. (2008). Pesticide/environmental exposures and Parkinson's disease in East Texas. Journal of Agromedicine, 13(1), 37–48.

    Article  PubMed  Google Scholar 

  • Edwards, S. C., Jedrychowski, W., Butscher, M., Camann, D., Kieltyka, A., Mroz, E., et al. (2010). Prenatal exposure to airborne polycyclic aromatic hydrocarbons and children's intelligence at 5 years of age in a prospective cohort study in Poland. Environmental Health Perspectives, 118(9), 1326–1331.

    Article  PubMed  PubMed Central  Google Scholar 

  • Fedorovich, S. V., Alekseenko, A. V., & Waseem, T. V. (2010). Are synapses targets of nanoparticles? Biochemical Society Transactions, 38(2), 536–538.

    Article  PubMed  Google Scholar 

  • Ferri, R., Rundo, F., Bruni, O., Terzano, M. G., & Stam, C. J. (2008). The functional connectivity of different EEG bands moves towards small-world network organization during sleep. Clinical Neurophysiology, 119(9), 2026–2036.

    Article  PubMed  Google Scholar 

  • Gass, J. T., & Olive, M. F. (2008). Glutamatergic substrates of drug addiction and alcoholism. Biochemical Pharmacology, 75(1), 218–265.

    Article  PubMed  Google Scholar 

  • Gerlofs-Nijland, M. E., van Berlo, D., Cassee, F. R., Schins, R. P., Wang, K., & Campbell, A. (2010). Effect of prolonged exposure to diesel engine exhaust on proinflammatory markers in different regions of the rat brain. Particle and Fibre Toxicology, 7, 12.

    Article  PubMed  PubMed Central  Google Scholar 

  • Gläscher, J., Tranel, D., Paul, L. K., Rudrauf, D., Rorden, C., Hornaday, A., Grabowski, T., Damasio, H., & Adolphs, R. (2009). Lesion mapping of cognitive abilities linked to intelligence. Neuron, 61(5), 681–691.

    Article  PubMed  PubMed Central  Google Scholar 

  • Gläscher, J., Rudrauf, D., Colom, R., Paul, L. K., Tranel, D., Damasio, H., & Adolphs, R. (2010). Distributed neural system for general intelligence revealed by lesion mapping. Proceedings of the National Academy of Sciences of the United States of America, 107(10), 4705–4709.

    Article  PubMed  PubMed Central  Google Scholar 

  • Goddard, C. A., Butts, D. A., & Shatz, C. J. (2007). Regulation of CNS synapses by neuronal MHC class I. Proceedings of the National Academy of Sciences of the United States of America, 104(16), 6828–6833.

    Article  PubMed  PubMed Central  Google Scholar 

  • Goldberg, N. D., O'Dea, R. F., & Haddox, M. K. (1973). Cyclic GMP. Advances in Cyclic Nucleotide Research, 3, 155–223.

    PubMed  Google Scholar 

  • Goldman, S. M. (2014). Environmental toxins and Parkinson's disease. Annual Review of Pharmacology and Toxicology, 54, 141–164.

    Article  PubMed  Google Scholar 

  • Goldman, D., Oroszi, G., & Ducci, F. (2005). The genetics of addictions: uncovering the genes. Nature Reviews. Genetics, 6(7), 521–532.

    Article  PubMed  Google Scholar 

  • Gonatas, N. K., & Moss, A. (1975). Pathologic axons and synapses in human neuropsychiatric disorders. Human Pathology, 6(5), 571–582.

    Article  PubMed  Google Scholar 

  • Gong, G., & O’Bryant, S. E. (2010). The arsenic exposure hypothesis for Alzheimer disease. Alzheimer Disease and Associated Disorders, 24(4), 311–316.

    Article  PubMed  Google Scholar 

  • Gong, L., Pan, Y. X., & Chen, H. (2010). Gestational low protein diet in the rat mediates Igf2 gene expression in male offspring via altered hepatic DNA methylation. Epigenetics, 5(7), 619–626.

    Article  PubMed  Google Scholar 

  • González-Forero, D., Portillo, F., Gómez, L., Montero, F., Kasparov, S., & Moreno-López, B. (2007). Inhibition of resting potassium conductances by long-term activation of the NO/cGMP/protein kinase G pathway: a new mechanism regulating neuronal excitability. The Journal of Neuroscience, 27(23), 6302–6312.

    Article  PubMed  Google Scholar 

  • Gonzalez-Pina, R., Escalante-Membrillo, C., Alfaro-Rodriguez, A., & Gonzalez-Maciel, A. (2008). Prenatal exposure to ozone disrupts cerebellar monoamine contents in newborn rats. Neurochemical Research, 33(5), 912–918.

    Article  PubMed  Google Scholar 

  • Gottesman, I. I., & Gould, T. D. (2003). The endophenotype concept in psychiatry: etymology and strategic intentions. The American Journal of Psychiatry, 160(4), 636–645.

    Article  PubMed  Google Scholar 

  • Greicius, M. D., Supekar, K., Menon, V., & Dougherty, R. F. (2009). Resting-state functional connectivity reflects structural connectivity in the default mode network. Cerebral Cortex, 19(1), 72–78.

    Article  PubMed  Google Scholar 

  • Hagmann, P., Kurant, M., Gigandet, X., Thiran, P., Wedeen, V. J., Meuli, R., & Thiran, J. P. (2007). Mapping human whole-brain structural networks with diffusion MRI. PLoS One, 2(7), e597.

    Article  PubMed  PubMed Central  Google Scholar 

  • Hagmann, P., Cammoun, L., Gigandet, X., Meuli, R., Honey, C. J., Wedeen, V. J., & Sporns, O. (2008). Mapping the structural core of human cerebral cortex. PLoS Biology, 6(7), e159. doi:10.1371/journal.pbio.0060159.

    Article  PubMed  PubMed Central  Google Scholar 

  • Haier, R. J., Jung, R. E., Yeo, R. A., Head, K., & Alkire, M. T. (2004). Structural brain variation and general intelligence. NeuroImage, 23(1), 425–433.

    Article  PubMed  Google Scholar 

  • Hariri, A. R., Drabant, E. M., & Weinberger, D. R. (2006). Imaging genetics: perspectives from studies of genetically driven variation in serotonin function and corticolimbic affective processing. Biological Psychiatry, 59(10), 888–897.

    Article  PubMed  Google Scholar 

  • Hatcher, J. M., Pennell, K. D., & Miller, G. W. (2008). Parkinson's disease and pesticides: a toxicological perspective. Trends in Pharmacological Sciences, 29(6), 322–329.

    Article  PubMed  Google Scholar 

  • Hemmer, B., Cepok, S., Nessler, S., & Sommer, N. (2002). Pathogenesis of multiple sclerosis: an update on immunology. Current Opinion in Neurology, 15(3), 227–231.

    Article  PubMed  Google Scholar 

  • Holmes, A., Kinney, J. W., Wrenn, C. C., Li, Q., Yang, R. J., Ma, L., et al. (2003). Galanin GAL-R1 receptor null mutant mice display increased anxiety-like behavior specific to the elevated plus-maze. Neuropsychopharmacology, 28(6), 1031–1044.

    PubMed  Google Scholar 

  • Holtmaat, A., & Svoboda, K. (2009). Experience-dependent structural synaptic plasticity in the mammalian brain. Nature Reviews. Neuroscience, 10(9), 647–658.

    Article  PubMed  Google Scholar 

  • Höschl, C., & Hajek, T. (2001). Hippocampal damage mediated by corticosteroids—a neuropsychiatric research challenge. European Archives of Psychiatry and Clinical Neuroscience, 251(Suppl 2), II81–II88.

    Article  PubMed  Google Scholar 

  • Hou, L., Zhu, Z. Z., Zhang, X., Nordio, F., Bonzini, M., Schwartz, J., et al. (2010). Airborne particulate matter and mitochondrial damage: a cross-sectional study. Environmental Health, 9, 48. doi:10.1186/1476-069X-9-48.

    Article  PubMed  PubMed Central  Google Scholar 

  • Hsieh, H., Boehm, J., Sato, C., Iwatsubo, T., Tomita, T., Sisodia, S., & Malinow, R. (2006). AMPAR removal underlies Abeta-induced synaptic depression and dendritic spine loss. Neuron, 52(5), 831–843.

    Article  PubMed  PubMed Central  Google Scholar 

  • Hunot, S., & Hirsch, E. C. (2003). Neuroinflammatory processes in Parkinson's disease. Annals of Neurology, 53(Suppl 3), S49–S58.

    Article  PubMed  Google Scholar 

  • Iturria-Medina, Y., Sotero, R. C., Canales-Rodríguez, E. J., Alemán-Gómez, Y., & Melie-García, L. (2008). Studying the human brain anatomical network via diffusion-weighted MRI and graph theory. NeuroImage, 40(3), 1064–1076.

    Article  PubMed  Google Scholar 

  • Jacob, T. C., Moss, S. J., & Jurd, R. (2008). GABA(A) receptor trafficking and its role in the dynamic modulation of neuronal inhibition. Nature Reviews. Neuroscience, 9(5), 331–343.

    Article  PubMed  PubMed Central  Google Scholar 

  • Jardim, M. J. (2011). microRNAs: implications for air pollution research. Mutation Research, 717(1–2), 38–45.

    Article  PubMed  Google Scholar 

  • Jensen, O., Kaiser, J., & Lachaux, J. P. (2007). Human gamma-frequency oscillations associated with attention and memory. Trends in Neurosciences, 30(7), 317–324.

    Article  PubMed  Google Scholar 

  • Kasai, H., Matsuzaki, M., Noguchi, J., Yasumatsu, N., & Nakahara, H. (2003). Structure-stability-function relationships of dendritic spines. Trends in Neurosciences, 26(7), 360–368.

    Article  PubMed  Google Scholar 

  • Katusic, Z. S., & Austin, S. A. (2014). Endothelial nitric oxide: protector of a healthy mind. European Heart Journal, 35(14), 888–894.

    Article  PubMed  Google Scholar 

  • Kauer, J. A., & Malenka, R. C. (2007 Nov). Synaptic plasticity and addiction. Nature Reviews. Neuroscience, 8(11), 844–858.

    Article  PubMed  Google Scholar 

  • Kaur, D., Peng, J., Chinta, S. J., Rajagopalan, S., Di Monte, D. A., Cherny, R. A., & Andersen, J. K. (2007). Increased murine neonatal iron intake results in Parkinson-like neurodegeneration with age. Neurobiology of Aging, 28(6), 907–913.

    Article  PubMed  Google Scholar 

  • Kim, H. S., Shin, N. Y., Jang, J. H., Kim, E., Shim, G., Park, H. Y., Hong, K. S., & Kwon, J. S. (2011). Social cognition and neurocognition as predictors of conversion to psychosis in individuals at ultra-high risk. Schizophrenia Research, 130(1–3), 170–175.

    Article  PubMed  Google Scholar 

  • Kitzbichler, M. G., Smith, M. L., Christensen, S. R., & Bullmore, E. (2009). Broadband criticality of human brain network synchronization. PLoS Computational Biology, 5(3), e1000314. doi:10.1371/journal.pcbi.1000314.

    Article  PubMed  PubMed Central  Google Scholar 

  • Knyazev, G. G., Volf, N. V., & Belousova, L. V. (2015). Age-related differences in electroencephalogram connectivity and network topology. Neurobiology of Aging, 36(5), 1849–1859.

    Article  PubMed  Google Scholar 

  • Konrad, K., & Eickhoff, S. B. (2010). Is the ADHD brain wired differently? A review on structural and functional connectivity in attention deficit hyperactivity disorder. Human Brain Mapping, 31(6), 904–916.

    Article  PubMed  Google Scholar 

  • Kwok, J. B. (2010). Role of epigenetics in Alzheimer's and Parkinson's disease. Epigenomics, 2(5), 671–682.

    Article  PubMed  Google Scholar 

  • Lehnertz, K., Bialonski, S., Horstmann, M. T., Krug, D., Rothkegel, A., Staniek, M., & Wagner, T. (2009). Synchronization phenomena in human epileptic brain networks. Journal of Neuroscience Methods, 183(1), 42–48.

    Article  PubMed  Google Scholar 

  • Leistedt, S. J., Coumans, N., Dumont, M., Lanquart, J. P., Stam, C. J., & Linkowski, P. (2009). Altered sleep brain functional connectivity in acutely depressed patients. Human Brain Mapping, 30(7), 2207–2219.

    Article  PubMed  Google Scholar 

  • Levesque, S., Surace, M. J., McDonald, J., & Block, M. L. (2011). Air pollution & the brain: subchronic diesel exhaust exposure causes neuroinflammation and elevates early markers of neurodegenerative disease. Journal of Neuroinflammation, 8, 105.

    Article  PubMed  PubMed Central  Google Scholar 

  • Levinson, D. F. (2005). Meta-analysis in psychiatric genetics. Current Psychiatry Reports, 7(2), 143–151.

    Article  PubMed  Google Scholar 

  • Liu, M., Choi, D. Y., Hunter, R. L., Pandya, J. D., Cass, W. A., Sullivan, P. G., Kim, H. C., Gash, D. M., & Bing, G. (2010 Feb). Trichloroethylene induces dopaminergic neurodegeneration in Fisher 344 rats. Journal of Neurochemistry, 112(3), 773–783.

    Article  PubMed  Google Scholar 

  • Logroscino, G. (2005). The role of early life environmental risk factors in Parkinson disease: what is the evidence? Environmental Health Perspectives, 113(9), 1234–1238.

    Article  PubMed  PubMed Central  Google Scholar 

  • Lord, C., Cook, E. H., Leventhal, B. L., & Amaral, D. G. (2000). Autism spectrum disorders. Neuron, 28(2), 355–363.

    Article  PubMed  Google Scholar 

  • Lu, C. S., Huang, C. C., Chu, N. S., & Calne, D. B. (1994). Levodopa failure in chronic manganism. Neurology, 44(9), 1600–1602.

    Article  PubMed  Google Scholar 

  • Lu, Q., Qiu, X., Hu, N., Wen, H., Su, Y., & Richardson, B. C. (2006). Epigenetics, disease, and therapeutic interventions. Ageing Research Reviews, 5(4), 449–467.

    Article  PubMed  Google Scholar 

  • Luccini, R., Dorman, D., Elder, A., & Veroneci, B. (2011). Neurological impacts from inhalation of pollutants and the nose-brain connection. NeuroToxicology, 33(4). doi:10.1016/j.neuro.2011.12.001

  • Lynch, M. A. (2009). The multifaceted profile of activated microglia. Molecular Neurobiology, 40(2), 139–156.

    Article  PubMed  Google Scholar 

  • Maher, F. O., Nolan, Y., & Lynch, M. A. (2005). Downregulation of IL-4-induced signalling in hippocampus contributes to deficits in LTP in the aged rat. Neurobiology of Aging, 26(5), 717–728.

    Article  PubMed  Google Scholar 

  • Malenka, R. C., & Nicoll, R. A. (1999). Long-term potentiation—a decade of progress? Science, 285(5435), 1870–1874.

    Article  PubMed  Google Scholar 

  • Malinow, R., & Malenka, R. C. (2002). AMPA receptor trafficking and synaptic plasticity. Annual Review of Neuroscience, 25, 103–126.

    Article  PubMed  Google Scholar 

  • Mariussen, E., Morch Andersen, J., & Fonnum, F. (1999). The effect of polychlorinated biphenyls on the uptake of dopamine and other neurotransmitters into rat brain synaptic vesicles. Toxicology and Applied Pharmacology, 161(3), 274–282.

    Article  PubMed  Google Scholar 

  • Marques, S. C., Oliveira, C. R., Pereira, C. M., & Outeiro, T. F. (2011). Epigenetics in neurodegeneration: a new layer of complexity. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 35(2), 348–355.

    Article  Google Scholar 

  • Mattson, M. P. (2010). ER calcium and Alzheimer's disease: in a state of flux. Science Signaling, 3(114), pe10. doi:10.1126/scisignal.3114pe10.

    Article  PubMed  PubMed Central  Google Scholar 

  • Mazzoli-Rocha, F., Fernandes, S., Einicker-Lamas, M., & Zin, W. A. (2010). Roles of oxidative stress in signaling and inflammation induced by particulate matter. Cell Biology and Toxicology, 26(5), 481–498.

    Article  PubMed  Google Scholar 

  • Micheloyannis, S., Pachou, E., Stam, C. J., Breakspear, M., Bitsios, P., Vourkas, M., Erimaki, S., & Zervakis, M. (2006). Small-world networks and disturbed functional connectivity in schizophrenia. Schizophrenia Research, 87(1–3), 60–66.

    Article  PubMed  Google Scholar 

  • Micheloyannis, S., Vourkas, M., Tsirka, V., Karakonstantaki, E., Kanatsouli, K., & Stam, C. J. (2009). The influence of ageing on complex brain networks: a graph theoretical analysis. Human Brain Mapping, 30(1), 200–208.

    Article  PubMed  Google Scholar 

  • Migliore, L., & Coppedè, F. (2009). Environmental-induced oxidative stress in neurodegenerative disorders and aging. Mutation Research, 674(1–2), 73–84.

    Article  PubMed  Google Scholar 

  • Moffitt, T. E., Caspi, A., & Rutter, M. (2005). Strategy for investigating interactions between measured genes and measured environments. Archives of General Psychiatry, 62(5), 473–481.

    Article  PubMed  Google Scholar 

  • Morse, D. C., Seegal, R. F., Borsch, K. O., & Brouwer, A. (1996). Long-term alterations in regional brain serotonin metabolism following maternal polychlorinated biphenyl exposure in the rat. Neurotoxicology, 17(3–4), 631–638.

    PubMed  Google Scholar 

  • Murias, M., Swanson, J. M., & Srinivasan, R. (2007). Functional connectivity of frontal cortex in healthy and ADHD children reflected in EEG coherence. Cerebral Cortex, 17(8), 1788–1799.

    Article  PubMed  Google Scholar 

  • Nathan, C., & Xie, Q. W. (1994). Nitric oxide synthases: roles, tolls, and controls. Cell, 78(6), 915–918.

    Article  PubMed  Google Scholar 

  • Niemi, W. D., Audi, J., Bush, B., & Carpenter, D. O. (1998). PCBs reduce long-term potentiation in the CA1 region of rat hippocampus. Experimental Neurology, 151(1), 26–34.

    Article  PubMed  Google Scholar 

  • Nomura, Y., Uehara, T., & Nakazawa, M. (1996). Neuronal apoptosis by glial NO: involvement of inhibition of glyceraldehyde-3-phosphate dehydrogenase. Human Cell, 9(3), 205–214.

    PubMed  Google Scholar 

  • Oberdörster, G., Elder, A., & Rinderknecht, A. (2009). Nanoparticles and the brain: cause for concern? Journal of Nanoscience and Nanotechnology, 9(8), 4996–5007.

    Article  PubMed  PubMed Central  Google Scholar 

  • O'Bryant, S. E., Xiao, G., Barber, R., Reisch, J., Hall, J., Cullum, C. M., et al. (2011). A blood-based algorithm for the detection of Alzheimer's disease. Dementia and Geriatric Cognitive Disorders, 32(1), 55–62.

    Article  PubMed  PubMed Central  Google Scholar 

  • Ottet, M. C., Schaer, M., Cammoun, L., Schneider, M., Debbané, M., Thiran, J. P., & Eliez, S. (2013). Reduced fronto-temporal and limbic connectivity in the 22q11.2 deletion syndrome: vulnerability markers for developing schizophrenia? PLoS One, 8(3), e58429. doi:10.1371/journal.pone.0058429.

    Article  PubMed  PubMed Central  Google Scholar 

  • Ovrevik, J., Låg, M., Holme, J. A., Schwarze, P. E., & Refsnes, M. (2009). Cytokine and chemokine expression patterns in lung epithelial cells exposed to components characteristic of particulate air pollution. Toxicology, 259(1–2), 46–53.

    Article  PubMed  Google Scholar 

  • Owen, M. J., Williams, N. M., & O'Donovan, M. C. (2004). Dysbindin-1 and schizophrenia: from genetics to neuropathology. The Journal of Clinical Investigation, 113(9), 1255–1257.

    Article  PubMed  PubMed Central  Google Scholar 

  • Pandey, A. K., & Deshpande, S. B. (2012). Bisphenol A depresses compound action potential of frog sciatic nerve in vitro involving Ca(2+)-dependent mechanisms. Neuroscience Letters, 517(2), 128–132.

    Article  PubMed  Google Scholar 

  • Pandey, A. K., & Deshpande, S. B. (2015). Bisphenol A depresses monosynaptic and polysynaptic reflexes in neonatal rat spinal cord in vitro involving estrogen receptor-dependent NO-mediated mechanisms. Neuroscience, 289, 349–357.

    Article  PubMed  Google Scholar 

  • Pandey, G., & Pandey, A. K. (2013). Nutrition research perspectives in immune mediated inflammatory disorders. Indian Journal of Rheumatology, 8, 30–36.

    Article  Google Scholar 

  • Pandey, A. K., Pandey, G., Pandey, S. S., & Pandey, B. L. (2014). Human biology of diet and lifestyle linked chronic inflammatory non-communicable disease epidemic—a review. Human Biology Review, 3(1), 25–42.

    Google Scholar 

  • Pereda, E., Quiroga, R. Q., & Bhattacharya, J. (2005). Nonlinear multivariate analysis of neurophysiological signals. Progress in Neurobiology, 77(1–2), 1–37.

    Article  PubMed  Google Scholar 

  • Pijnenburg, Y. A., vd Made, Y., Cappellen, V., van Walsum, A. M., Knol, D. L., Scheltens, P., & Stam, C. J. (2004). EEG synchronization likelihood in mild cognitive impairment and Alzheimer's disease during a working memory task. Clinical Neurophysiology, 115(6), 1332–1339.

    Article  PubMed  Google Scholar 

  • Pogarell, O., Teipel, S. J., Juckel, G., Gootjes, L., Möller, T., Bürger, K., et al. (2005). EEG coherence reflects regional corpus callosum area in Alzheimer's disease. Journal of Neurology, Neurosurgery, and Psychiatry, 76(1), 109–111.

    Article  PubMed  PubMed Central  Google Scholar 

  • Power, M. C., Weisskopf, M. G., Alexeeff, S. E., Coull, B. A., Spiro 3rd, A., & Schwartz, J. (2011). Traffic-related air pollution and cognitive function in a cohort of older men. Environmental Health Perspectives, 119(5), 682–687.

    Article  PubMed  Google Scholar 

  • Praticò, D., Uryu, K., Sung, S., Tang, S., Trojanowski, J. Q., & Lee, V. M. (2002). Aluminum modulates brain amyloidosis through oxidative stress in APP transgenic mice. The FASEB Journal, 16(9), 1138–1140.

    PubMed  Google Scholar 

  • Ramocki, M. B., & Zoghbi, H. Y. (2008). Failure of neuronal homeostasis results in common neuropsychiatric phenotypes. Nature, 455(7215), 912–918.

    Article  PubMed  PubMed Central  Google Scholar 

  • Rice, D., & Barone Jr., S. (2000). Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models. Environmental Health Perspectives, 108(Suppl 3), 511–533.

    Article  PubMed  PubMed Central  Google Scholar 

  • Rivas-Manzano, P., & Paz, C. (1999). Cerebellar morphological alterations in rats induced by prenatal ozone exposure. Neuroscience Letters, 276(1), 37–40.

    Article  PubMed  Google Scholar 

  • Rossini, P. M., Del Percio, C., Pasqualetti, P., Cassetta, E., Binetti, G., Dal Forno, G., et al. (2006). Conversion from mild cognitive impairment to Alzheimer's disease is predicted by sources and coherence of brain electroencephalography rhythms. Neuroscience, 143(3), 793–803.

    Article  PubMed  Google Scholar 

  • Rubinov, M., Knock, S. A., Stam, C. J., Micheloyannis, S., Harris, A. W., Williams, L. M., & Breakspear, M. (2009). Small-world properties of nonlinear brain activity in schizophrenia. Human Brain Mapping, 30(2), 403–416.

    Article  PubMed  Google Scholar 

  • Salnikov, V., Lukyánenko, Y. O., Frederick, C. A., Lederer, W. J., & Lukyánenko, V. (2007). Probing the outer mitochondrial membrane in cardiac mitochondria with nanoparticles. Biophysical Journal, 92(3), 1058–1071.

    Article  PubMed  Google Scholar 

  • Santucci, D., Sorace, A., Francia, N., Aloe, L., & Alleva, E. (2006). Prolonged prenatal exposure to low-level ozone affects aggressive behaviour as well as NGF and BDNF levels in the central nervous system of CD-1 mice. Behavioural Brain Research, 166(1), 124–130.

    Article  PubMed  Google Scholar 

  • Schantz, S. L., Gasior, D. M., Polverejan, E., McCaffrey, R. J., Sweeney, A. M., Humphrey, H. E., et al. (2001). Impairments of memory and learning in older adults exposed to polychlorinated biphenyls via consumption of Great Lakes fish. Environmental Health Perspectives, 109(6), 605–611.

    Article  PubMed  PubMed Central  Google Scholar 

  • Schmithorst, V. J., Wilke, M., Dardzinski, B. J., & Holland, S. K. (2005). Cognitive functions correlate with white matter architecture in a normal pediatric population: a diffusion tensor MRI study. Human Brain Mapping, 26(2), 139–147.

    Article  PubMed  PubMed Central  Google Scholar 

  • Schmitt, J. E., Lenroot, R. K., Wallace, G. L., Ordaz, S., Taylor, K. N., Kabani, N., et al. (2008). Identification of genetically mediated cortical networks: a multivariate study of pediatric twins and siblings. Cerebral Cortex, 18(8), 1737–1747.

    Article  PubMed  PubMed Central  Google Scholar 

  • Schneider, H., Pitossi, F., Balschun, D., Wagner, A., del Rey, A., & Besedovsky, H. O. (1998). A neuromodulatory role of interleukin-1beta in the hippocampus. Proceedings of the National Academy of Sciences of the United States of America, 95(13), 7778–7783.

    Article  PubMed  PubMed Central  Google Scholar 

  • Schoonheim, M. M., Hulst, H. E., Landi, D., Ciccarelli, O., Roosendaal, S. D., Sanz-Arigita, E. J., et al. (2012). Gender-related differences in functional connectivity in multiple sclerosis. Multiple Sclerosis, 18(2), 164–173.

    Article  PubMed  Google Scholar 

  • Selkoe, D. J. (2002). Alzheimer's disease is a synaptic failure. Science, 298(5594), 789–791.

    Article  PubMed  Google Scholar 

  • Sendiña-Nadal, I., Buldú, J. M., Leyva, I., Bajo, R., Almendral, J. A., & del-Pozo, F. (2011). Integration versus segregation in functional brain networks. IEEE Transactions on Biomedical Engineering, 58(10), 3004–3007.

    Article  PubMed  Google Scholar 

  • Sharma, H. S., & Sharma, A. (2012 Feb). Neurotoxicity of engineered nanoparticles from metals. CNS & Neurological Disorders Drug Targets, 11(1), 65–80.

    Article  Google Scholar 

  • Sharma, H. S., Ali, S. F., Hussain, S. M., Schlager, J. J., & Sharma, A. (2009). Influence of engineered nanoparticles from metals on the blood-brain barrier permeability, cerebral blood flow, brain edema and neurotoxicity. An experimental study in the rat and mice using biochemical and morphological approaches. Journal of Nanoscience and Nanotechnology, 9(8), 5055–5072.

    Article  PubMed  Google Scholar 

  • Siddique, S., Banerjee, M., Ray, M. R., & Lahiri, T. (2011). Attention-deficit hyperactivity disorder in children chronically exposed to high level of vehicular pollution. European Journal of Pediatrics, 170(7), 923–929.

    Article  PubMed  Google Scholar 

  • Simon, H. A. (1962). The architecture of complexity. Proceedings of the American Philosophical Society, 106(6), 467–482.

    Google Scholar 

  • Sisó, S., González, L., & Jeffrey, M. (2010). Neuroinvasion in prion diseases: the roles of ascending neural infection and blood dissemination. Interdisciplinary Perspectives on Infectious Diseases, 2010, 747892. doi:10.1155/2010/747892.

    Article  PubMed  PubMed Central  Google Scholar 

  • Spencer, P. S., & Palmer, V. S. (2012). Interrelationships of undernutrition and neurotoxicity: food for thought and research attention. Neurotoxicology, 33(3), 605–616.

    Article  PubMed  PubMed Central  Google Scholar 

  • Spillantini, M. G., Crowther, R. A., Jakes, R., Hasegawa, M., & Goedert, M. (1998). alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proceedings of the National Academy of Sciences of the United States of America, 95(11), 6469–6473.

    Article  PubMed  PubMed Central  Google Scholar 

  • Sporns, O., & Zwi, J. D. (2004). The small world of the cerebral cortex. Neuroinformatics, 2(2), 145–162.

    Article  PubMed  Google Scholar 

  • Srinivasan, R., Thorpe, S., & Nunez, P. L. (2013). Top-down influences on local networks: basic theory with experimental implications. Frontiers in Computational Neuroscience, 7, 29.

    Article  PubMed  PubMed Central  Google Scholar 

  • Stam, C. J., & de Bruin, E. A. (2004). Scale-free dynamics of global functional connectivity in the human brain. Human Brain Mapping, 22(2), 97–109.

    Article  PubMed  Google Scholar 

  • Stam, C. J., & van Straaten, E. C. (2012). The organization of physiological brain networks. Clinical Neurophysiology, 123(6), 1067–1087.

    Article  PubMed  Google Scholar 

  • Stam, C. J., de Haan, W., Daffertshofer, A., Jones, B. F., Manshanden, I., van Cappellen van Walsum, A. M., et al. (2009). Graph theoretical analysis of magnetoencephalographic functional connectivity in Alzheimer's disease. Brain, 132(Pt 1), 213–224.

    Article  PubMed  Google Scholar 

  • Steinert, J. R., Robinson, S. W., Tong, H., Haustein, M. D., Kopp-Scheinpflug, C., & Forsythe, I. D. (2011). Nitric oxide is an activity-dependent regulator of target neuron intrinsic excitability. Neuron, 71(2), 291–305.

    Article  PubMed  PubMed Central  Google Scholar 

  • Südhof, T. C. (2008). Neuroligins and neurexins link synaptic function to cognitive disease. Nature, 455(7215), 903–911.

    Article  PubMed  PubMed Central  Google Scholar 

  • Suglia, S. F., Gryparis, A., Wright, R. O., Schwartz, J., & Wright, R. J. (2008). Association of black carbon with cognition among children in a prospective birth cohort study. American Journal of Epidemiology, 167(3), 280–286.

    Article  PubMed  Google Scholar 

  • Sunico, C. R., Portillo, F., González-Forero, D., & Moreno-López, B. (2005). Nitric-oxide-directed synaptic remodeling in the adult mammal CNS. The Journal of Neuroscience, 25(6), 1448–1458.

    Article  PubMed  Google Scholar 

  • Sunyer, J. (2008). The neurological effects of air pollution in children. The European Respiratory Journal, 32(3), 535–537.

    Article  PubMed  Google Scholar 

  • Tabuchi, K., Blundell, J., Etherton, M. R., Hammer, R. E., Liu, X., Powell, C. M., & Südhof, T. C. (2007). A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in mice. Science, 318(5847), 71–76.

    Article  PubMed  PubMed Central  Google Scholar 

  • Tancredi, V., D'Antuono, M., Cafè, C., Giovedì, S., Buè, M. C., D'Arcangelo, G., Onofri, F., & Benfenati, F. (2000). The inhibitory effects of interleukin-6 on synaptic plasticity in the rat hippocampus are associated with an inhibition of mitogen-activated protein kinase ERK. Journal of Neurochemistry, 75(2), 634–643.

    Article  PubMed  Google Scholar 

  • Uhlhaas, P. J. (2011). High-frequency oscillations in schizophrenia. Clinical EEG and Neuroscience, 42(2), 77–82.

    Article  PubMed  Google Scholar 

  • Vahidnia, A., Romijn, F., van der Voet, G. B., & de Wolff, F. A. (2008). Arsenic-induced neurotoxicity in relation to toxicokinetics: effects on sciatic nerve proteins. Chemico-Biological Interactions, 176(2–3), 188–195.

    Article  PubMed  Google Scholar 

  • van Berlo, D., Albrecht, C., Knaapen, A. M., Cassee, F. R., Gerlofs-Nijland, M. E., Kooter, I. M., et al. (2010). Comparative evaluation of the effects of short-term inhalation exposure to diesel engine exhaust on rat lung and brain. Archives of Toxicology, 84(7), 553–562.

    Article  PubMed  PubMed Central  Google Scholar 

  • van den Heuvel, M. P., & Hulshoff Pol, H. E. (2010). Specific somatotopic organization of functional connections of the primary motor network during resting state. Human Brain Mapping, 31(4), 631–644.

    PubMed  Google Scholar 

  • van den Heuvel, M., Mandl, R., Luigjes, J., & Hulshoff, P. H. (2008). Microstructural organization of the cingulum tract and the level of default mode functional connectivity. The Journal of Neuroscience, 28(43), 10844–10851.

    Article  PubMed  Google Scholar 

  • Vereker, E., O'Donnell, E., & Lynch, M. A. (2000). The inhibitory effect of interleukin-1beta on long-term potentiation is coupled with increased activity of stress-activated protein kinases. The Journal of Neuroscience, 20(18), 6811–6819.

    PubMed  Google Scholar 

  • Verones, B., & Oortgiesen, M. (2001). Neurogenic inflammation and particulate matter (PM) air pollutants. Neurotoxicology, 22(6), 795–810.

    Article  PubMed  Google Scholar 

  • Vincent, J. L., Kahn, I., Snyder, A. Z., Raichle, M. E., & Buckner, R. L. (2008). Evidence for a frontoparietal control system revealed by intrinsic functional connectivity. Journal of Neurophysiology, 100(6), 3328–3342.

    Article  PubMed  PubMed Central  Google Scholar 

  • Viviani, B., Boraso, M., Marchetti, N., & Marinovich, M. (2014). Perspectives on neuroinflammation and excitotoxicity: a neurotoxic conspiracy? Neurotoxicology, 43, 10–20.

    Article  PubMed  Google Scholar 

  • Volterra, A., & Meldolesi, J. (2005). Astrocytes, from brain glue to communication elements: the revolution continues. Nature Reviews. Neuroscience, 6(8), 626–640.

    Article  PubMed  Google Scholar 

  • Vrijheid, M., Martinez, D., Aguilera, I., Bustamante, M., Ballester, F., Estarlich, M., et al. (2012). Indoor air pollution from gas cooking and infant neurodevelopment. Epidemiology, 23(1), 23–32.

    Article  PubMed  Google Scholar 

  • Wang, B., & Du, Y. (2013). Cadmium and its neurotoxic effects. Oxidative Medicine and Cellular Longevity, 2013, 898034. doi:10.1155/2013/898034.

    PubMed  PubMed Central  Google Scholar 

  • Wang, S., Zhang, Z., Lu, G., & Luo, L. (2007). Localization of brain activity by temporal anti-correlation with the posterior cingulate cortex. Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2007, 5227–5230.

    Google Scholar 

  • Wang, S., Zhang, J., Zeng, X., Zeng, Y., Wang, S., & Chen, S. (2009). Association of traffic-related air pollution with children's neurobehavioral functions in Quanzhou, China. Environmental Health Perspectives, 117(10), 1612–1618.

    Article  PubMed  PubMed Central  Google Scholar 

  • Wang, J., Barstein, J., Ethridge, L. E., Mosconi, M. W., Takarae, Y., & Sweeney, J. A. (2013). Resting state EEG abnormalities in autism spectrum disorders. Journal of Neurodevelopmental Disorders, 5(1), 24. doi:10.1186/1866-1955-5-24.

    Article  PubMed  PubMed Central  Google Scholar 

  • Wilker, E. H., Preis, S. R., Beiser, A. S., Wolf, P. A., Au, R., Kloog, I., et al. (2015). Long-term exposure to fine particulate matter, residential proximity to major roads and measures of brain structure. Stroke, 46(5), 1161–1166.

    Article  PubMed  PubMed Central  Google Scholar 

  • Windham, G. C., Zhang, L., Gunier, R., Croen, L. A., & Grether, J. K. (2006). Autism spectrum disorders in relation to distribution of hazardous air pollutants in the San Francisco Bay area. Environmental Health Perspectives, 114(9), 1438–1444.

    Article  PubMed  PubMed Central  Google Scholar 

  • Wirdefeldt, K., Adami, H. O., Cole, P., Trichopoulos, D., & Mandel, J. (2011). Epidemiology and etiology of Parkinson's disease: a review of the evidence. European Journal of Epidemiology, 26(Suppl 1), S1–58.

    Article  PubMed  Google Scholar 

  • Womelsdorf, T., & Fries, P. (2007). The role of neuronal synchronization in selective attention. Current Opinion in Neurobiology, 17(2), 154–160.

    Article  PubMed  Google Scholar 

  • Woolgar, A., Parr, A., Cusack, R., Thompson, R., Nimmo-Smith, I., Torralva, T., Roca, M., Antoun, N., Manes, F., & Duncan, J. (2010). Fluid intelligence loss linked to restricted regions of damage within frontal and parietal cortex. Proceedings of the National Academy of Sciences of the United States of America, 107(33), 14899–14902.

    Article  PubMed  PubMed Central  Google Scholar 

  • Wu, J., Wang, C., Sun, J., & Xue, Y. (2011). Neurotoxicity of silica nanoparticles: brain localization and dopaminergic neurons damage pathways. ACS Nano, 5(6), 4476–4489.

    Article  PubMed  Google Scholar 

  • Yamamoto, H., Saitoh, Y., Yasugawa, S., & Miyamoto, E. (1990). Dephosphorylation of tau factor by protein phosphatase 2A in synaptosomal cytosol fractions, and inhibition by aluminum. Neurochemistry, 55(2), 683–690.

    Article  Google Scholar 

  • Yang, W., & Omaye, S. T. (2009). Air pollutants, oxidative stress and human health. Mutation Research, 674(1–2), 45–54.

    Article  PubMed  Google Scholar 

  • Yuste, R., & Bonhoeffer, T. (2001). Morphological changes in dendritic spines associated with long-term synaptic plasticity. Annual Review of Neuroscience, 24, 1071–1089.

    Article  PubMed  Google Scholar 

  • Zarate Jr., C. A., Singh, J., & Manji, H. K. (2006). Cellular plasticity cascades: targets for the development of novel therapeutics for bipolar disorder. Biological Psychiatry, 59(11), 1006–1020.

    Article  PubMed  Google Scholar 

  • Zawia, N. H., Lahiri, D. K., & Cardozo-Pelaez, F. (2009). Epigenetics, oxidative stress, and Alzheimer disease. Free Radical Biology & Medicine, 46(9), 1241–1249.

    Article  Google Scholar 

  • Zhang, X., Yaseen, Z. S., Galynker, I. I., Hirsch, J., & Winston, A. (2011). Can depression be diagnosed by response to mother's face? A personalized attachment-based paradigm for diagnostic fMRI. PLoS One, 6(12), e27253. doi:10.1371/journal.pone.0027253.

    Article  PubMed  PubMed Central  Google Scholar 

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    Abhay Kumar Pandey

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Pandey, A.K. Disruption of Neurosynaptic Physiology and Neuron Network Dysfunction in Brain Disorders: an Environmental and Occupational Health Perspective. Act Nerv Super 59, 61–77 (2017). https://doi.org/10.1007/s41470-017-0007-y

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