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In vivo SPECT imaging of an 131I-labeled PM 2.5 mimic substitute

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Abstract

The health effects of ambient PM 2.5 and its potential mechanisms have generated considerable interest. In vitro cell studies and ex vivo animal experiments may not accurately determine the characteristics of PM 2.5 particles. To better understand their detailed mechanisms, we performed an in vivo study using single photon emission tomography (SPECT) imaging. To mimic the PM 2.5 particles, SiO2 nanoparticles modified by ethylene carbonate or polyvinyl pyrrolidone were labeled with 131I. After administration via inhalation, in vivo SPECT imaging of the radiolabeled particles in sprague dawley rats was performed. It was found that radioactivity accumulated in the lungs and trachea 6 and 24 h after administration. In addition, significant radioactivity was observed in the abdomen, including the liver and kidneys. The results were also confirmed by ex vivo autoradiography. This study revealed that in vivo SPECT imaging could be an effective method for investigating the properties of PM 2.5 particles.

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Authors and Affiliations

  1. Key Laboratory of Synthetic and Biological Colloids, School of Chemical and Material Engineering, Ministry of Education, Jiangnan University, Wuxi, 214122, China

    Dong-Hui Pan, Dong-Jian Shi & Ming-Qing Chen

  2. Key Laboratory of Nuclear Medicine, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Ministry of Health, Jiangsu Institute of Nuclear Medicine, Wuxi, 214063, China

    Dong-Hui Pan, Jie Sheng, Xin-Yu Wang, Qian-Huan Huang, Jun-Jie Yan, Li-Zhen Wang, Run-Ling Yang & Yu-Ping Xu

Authors
  1. Dong-Hui Pan
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  2. Jie Sheng
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  3. Xin-Yu Wang
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  4. Qian-Huan Huang
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Correspondence to Yu-Ping Xu or Ming-Qing Chen.

Additional information

This work was supported by the National Natural Science Foundation of China (Nos. 31671035, 51803082), National Significant New Drugs Creation Program (No. 2017ZX09304021), Jiangsu Province Foundation (Nos. BK20170204, BK20161137), and Jiangsu Provincial Medical Innovation Team (Nos. CXTDA2017024, LGY2017088, QNRC2016628).

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Pan, DH., Sheng, J., Wang, XY. et al. In vivo SPECT imaging of an 131I-labeled PM 2.5 mimic substitute. NUCL SCI TECH 31, 111 (2020). https://doi.org/10.1007/s41365-020-00818-2

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