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Journal of Plant Diseases and Protection

, Volume 125, Issue 2, pp 131–132 | Cite as

Revisiting wishful thinking: the need of molecular tools to accurately assess the risks associated with microbial biocontrol agents

  • Holger B. Deising
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In this issue of JPDP, Ben Lugtenberg comments on an opinion paper questioning the safety of biological control agents (Deising et al. 2017). Lugtenberg is commenting on concern(s) raised by Deising et al. (2017) that antagonistic biocontrol microbes newly introduced into agro-ecosystems establish confronting interactions, in which silent secondary metabolism gene clusters may be activated and synthesis of structurally and toxicologically unknown secondary metabolites may be synthesized. Synthesis of secondary metabolites may be induced either in the biocontrol agent(s) or in the microbial residents. In microbial consortia, exchange and enzymatic modification of secondary metabolites will give rise to a cocktail of compounds with unknown, possibly toxic or even carcinogenic function. Activation of secondary metabolite gene clusters and formation of novel compounds in microbial consortia have been shown (Deising et al. 2017, and references therein), are accepted in the scientific...

Notes

Compliance with ethical standards

Conflict of interest

The author declares that he has no conflict of interest.

References

  1. Cole RJ, Cox RH (1981) Handbook of toxic fungal metabolites. Academic, LondonGoogle Scholar
  2. Deising HB, Gase I, Kubo Y (2017) The unpredictable risk imposed by microbial secondary metabolites: How safe is biological control of plant diseases? J Plant Dis Prot 124:413–419CrossRefGoogle Scholar
  3. Georgianna DR, Fedorova ND, Burroughs JL, Dolezal AL, Bok J, Horowitz-Brown S, Woloshuk CP, Yu J, Keller NP, Payne GA (2010) Beyond aflatoxin: four distinct expression patterns and functional roles associated with Aspergillus flavus secondary metabolism gene clusters. Mol Plant Pathol 11:213–226CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Deutsche Phytomedizinische Gesellschaft 2018

Authors and Affiliations

  1. 1.Chair for Phytopathology and Plant Protection, Institute for Agricultural and Nutritional Sciences, Faculty for Natural Sciences IIIMartin-Luther-University Halle-WittenbergHalle (Saale)Germany

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