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Associations between 24-h sleep–wake patterns and cardiometabolic risk factors in youth seeking mental health care

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Abstract

One hundred and eleven youth with mental ill-health underwent systematic clinical, laboratory and actigraphy monitoring to report associations between 24-h sleep–wake patterns and cardiometabolic risk factors. Multiple linear regression analyses, controlling for medication usage and class, age and sex, found significant associations between: later sleep onset and BMI; standard variation (SV) in the sleep offset with both insulin values and the updated homeostatic model assessment of insulin resistance (HOMA2-IR) values; and the SV of the sleep midpoint with both poorer fasting insulin, and HOMA2-IR values. Further longitudinal research is required to determine the causative relationships between 24-h sleep–wake cycle patterns, and cardiometabolic outcomes.

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Funding

This study was partially funded by a philanthropic gift (The Liu McCabe Family Scholarship awarded to C.E.W), a National Health and Medical Research Council Australia Fellowship (No. 511921, awarded to I.B.H) and a philanthropic gift (the Caroline Quinn Research Grant awarded to J.S.C). The funders of this study had no involvement in the: study design; collection, analysis and reporting of the data; writing of the report; or decision to submit the paper for publication.

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Authors and Affiliations

  1. Youth Mental Health Team, Brain and Mind Centre, University of Sydney, Sydney, NSW, Australia

    Chloe E. Wilson, Joanne S. Carpenter, Yun Song, Nicholas Ho & Ian B. Hickie

Authors
  1. Chloe E. Wilson
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  2. Joanne S. Carpenter
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  3. Yun Song
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  4. Nicholas Ho
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  5. Ian B. Hickie
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Corresponding author

Correspondence to Chloe E. Wilson.

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On behalf of all the authors, the corresponding author states that there is no conflict of interest.

Ethics approval

The Human Research Ethics Committee of the University of Sydney approved our study.

Human animal rights

All the procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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All participants (or their guardians if under 16 years old) gave written informed consent for the use of routinely collected clinical data for research and publication purposes.

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Sponsors had no involvement in the study design; collection, analysis or interpretation of the data; writing of the report; or the decision to submit the manuscript for publication.

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Wilson, C.E., Carpenter, J.S., Song, Y. et al. Associations between 24-h sleep–wake patterns and cardiometabolic risk factors in youth seeking mental health care. Sleep Biol. Rhythms 19, 337–340 (2021). https://doi.org/10.1007/s41105-021-00314-z

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  • DOI: https://doi.org/10.1007/s41105-021-00314-z

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