Abstract
We report an adolescent case of malignant brain tumor who presented with an irregular sleep–wake cycle as the first significant clinical symptom. The patient was referred to us with a 1-year history of irregular sleep–wake cycle. Subsequently, she was diagnosed with a brain tumor in left temporal lobe, which severely compressed the brain stem. Postoperatively, her sleep–wake cycle normalized, suggesting that the tumor caused reversible dysfunction of the circadian rhythm. Irregular sleep–wake rhythm is most commonly seen in elderly with neurodegenerative disorders. This case suggests that organic causes should be considered when an irregular sleep–wake pattern is seen in adolescents.
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References
American Academy of Sleep Medicine. International classification of sleep disorders. 3rd ed. Darien: American Academy of Sleep Medicine; 2014.
Kroenke K, Spitzer RL, Williams JB. The PHQ-9: validity of a brief depression severity measure. J Gen Intern Med. 2001;16:606–13.
Armstrong TS, Vera-Bolanos E, Acquaye AA, Gilbert MR, Ladha H, Mendoza T. The symptom burden of primary brain tumors: evidence for a core set of tumor- and treatment-related symptoms. Neuro-Oncology. 2016;18:252–60.
Gustafsson M, Edvardsson T, Ahlstrom G. The relationship between function, quality of life and coping in patients with low-grade gliomas. Support Care Cancer. 2006;14:1205–12.
Mulrooney DA, Ness KK, Neglia JP, Whitton JA, Green DM, Zeltzer LK, et al. Fatigue and sleep disturbance in adult survivors of childhood cancer: a report from the childhood cancer survivor study (CCSS). Sleep. 2008;31:271–81.
Gapstur R, Gross CR, Ness K. Factors associated with sleep–wake disturbances in child and adult survivors of pediatric brain tumors: a review. Oncol Nurs Forum. 2009;36:723–31.
Wang JL, Lim AS, Chiang WY, Hsieh WH, Lo MT, Schneider JA, et al. Suprachiasmatic neuron numbers and rest-activity circadian rhythms in older humans. Ann Neurol. 2015;78:317–22.
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The authors are grateful to the patient and her parents for allowing us to publish this case report.
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Nakajima, S., Suzuki, M., Kaneko, Y. et al. Irregular sleep–wake cycle associated with malignant brain tumor in an adolescent. Sleep Biol. Rhythms 17, 459–461 (2019). https://doi.org/10.1007/s41105-019-00239-8
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DOI: https://doi.org/10.1007/s41105-019-00239-8