Abstract
A 74-year-old man presented with creepy, dull and restless sensation of the legs for a year. The abnormal leg sensation occurred predominantly during rest and evening. However, the patient denied having the urge to move his legs. The abnormal sensations did not fulfill the criteria for restless legs syndrome (RLS) or leg motor restlessness, a condition in which an urge to move the legs exists but not fulfilling 4 essential features of RLS. Neurological examination showed right-side dominant parkinsonism. Dopaminergic treatment provided marked improvement in the leg restlessness and parkinsonism. Any restlessness or abnormal sensation in the legs at late-onset could be an early sensorimotor manifestation of PD.
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References
Allen RP, Picchietti DL, Garcia-Borreguero D, Ondo WG, Walters AS, Winkelman JW, et al. Restless legs syndrome/Willis-Ekbom disease diagnostic criteria: updated International Restless Legs Syndrome Study Group (IRLSSG) consensus criteria–history, rationale, description, and significance. Sleep Med. 2014;15:860–73.
Moller JC, Unger M, Stiasny-Kolster K, Oertel WH. Restless legs syndrome (RLS) and Parkinson’s disease (PD)-related disorders or different entities? J Neurol Sci. 2010;289:135–7.
Trenkwalder C, Allen R, Hogl B, Paulus W, Winkelmann J. Restless legs syndrome associated with major diseases: a systematic review and new concept. Neurology. 2016;86:1336–43.
Angelini M, Negrotti A, Marchesi E, Bonavina G, Calzetti S. A study of the prevalence of restless legs syndrome in previously untreated Parkinson’s disease patients: absence of co-morbid association. J Neurol Sci. 2011;310:286–8.
Gjerstad MD, Tysnes OB, Larsen JP. Increased risk of leg motor restlessness but not RLS in early Parkinson disease. Neurology. 2011;77:1941–6.
Wong JC, Li Y, Schwarzschild MA, Ascherio A, Gao X. Restless legs syndrome: an early clinical feature of Parkinson disease in men. Sleep. 2014;37:369–72.
Suzuki K, Okuma Y, Uchiyama T, Miyamoto M, Sakakibara R, Shimo Y, et al. Characterizing restless legs syndrome and leg motor restlessness in patients with Parkinson’s disease: a multicenter case-controlled study. Parkinsonism Relat Disord. 2017;44:18–22
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Suzuki, K., Matsubara, T., Sakuramoto, H. et al. Uncomfortable and unpleasant sensations in the legs without an urge to move as the initial manifestation of Parkinson’s disease. Sleep Biol. Rhythms 16, 369–370 (2018). https://doi.org/10.1007/s41105-018-0160-z
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DOI: https://doi.org/10.1007/s41105-018-0160-z