Sleep and Biological Rhythms

, Volume 16, Issue 1, pp 107–115 | Cite as

Age- and gender-related differences of CPAP acceptance for obstructive sleep apnea syndrome in Taiwan

  • Yi-Chih Huang
  • Chou-Chin Lan
  • Yao-Kuang Wu
  • Wen-Lin Su
  • Mei-Chen YangEmail author
Original Article


In our previous study, we observed younger OSAS patients had higher CPAP acceptance but similar compliance as older OSAS patients, suggesting gender factor might play an important role on CPAP acceptance. Hence, we aimed to evaluate the influences of both gender and age on CPAP acceptance and compliance in Taiwanese OSAS patients. This retrospective study included 371 subjects which were subdivided by gender and age (younger: age < 55 years, and older: age ≥ 55 years) (n = 24 for younger women, n = 67 for older women, n = 131 for younger men; and n = 149 for older men). Anthropometric parameters, blood pressures, Epworth sleepiness scale, polysomnography variables, CPAP acceptance, and CPAP compliance were collected and compared. Univariate analysis evaluated the influence of different variables on CPAP acceptance. Due to the presence of multicollinearity for N3 sleep and AHI, as well as N3 sleep and DI, multivariate logistic regression models were conducted using three different models with N3 sleep, AHI, and DI included separately. Univariate analysis found women had less CPAP acceptance than men. Multivariate logistic regression analysis indicated younger women had lower CPAP acceptance, but in contrast younger men had higher CPAP acceptance. No difference was observed among the four subgroups for long-term CPAP compliance. In conclusion, our findings suggest that both age and gender impact CPAP acceptance for treating OSAS in Taiwan, with women having lower CPAP acceptance than men regardless of age. No apparent influence of age and gender on CPAP compliance was observed.


Obstructive sleep apnea syndrome Continuous positive airway pressure Acceptance Compliance Age Gender 



Apnea/hypopnea index


Coronary artery disease


Continuous positive airway pressure


Cardiovascular disease


Cerebrovascular accident


Diastolic blood pressure


Desaturation index


Excessive daytime sleepiness




Epworth sleepiness scale




Mean arterial pressure


Obstructive sleep apnea syndrome




Rapid eye movement


Oxygen saturation


Systolic blood pressure




Compliance with ethical standards

Author contributions

Literature search: CCL and WLS; data collection: YCH and MCY; study design: MCY and YKW; analysis of data: MCY; manuscript preparation: YCH and MCY; review of manuscript: YKW and MCY. All authors read and approved the study.


The study was supported by a grant from the Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation (TCRD-TPE-106-RT-1).

Conflict of interest

On behalf of all authors, the corresponding author states that there is no conflict of interest.

Ethical approval

The study was performed in accordance with the Declaration of Helsinki. The Institutional Review Board of the Taipei Tzuchi Hospital approved the protocol.

Informed consent

Since the study was retrospective in design, informed consent was not necessary.

Supplementary material

41105_2017_132_MOESM1_ESM.doc (66 kb)
Supplementary material 1 (DOC 65 KB)


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Copyright information

© Japanese Society of Sleep Research 2017

Authors and Affiliations

  • Yi-Chih Huang
    • 1
    • 2
  • Chou-Chin Lan
    • 1
    • 2
  • Yao-Kuang Wu
    • 1
    • 2
  • Wen-Lin Su
    • 1
    • 2
  • Mei-Chen Yang
    • 1
    • 2
    Email author
  1. 1.Division of Pulmonary Medicine, Department of Internal Medicine, Taipei Tzu-Chi HospitalBuddhist Tzu Chi Medical FoundationNew Taipei CityTaiwan
  2. 2.The School of MedicineTzu-Chi UniversityHualienTaiwan

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