Effects of total nocturnal sleep time and siesta on hepatocellular carcinoma risks in individuals with chronic HBV infection

  • Xu-Jin Liu
  • Fan Zhang
  • Yuan Liu
  • Yu-Chen Fan
  • Kai Wang
Original Article

Abstract

The aim of this study was to investigate the effects of total nocturnal sleep time and siesta on hepatocellular carcinoma (HCC) risks in chronic HBV infected individuals. This research was retrospective. A case–control study with 226 HCC patients and 375 controls enrolled was conducted. All subjects were chronic HBV infected. The total nocturnal sleep time and siesta or not were recorded by interview. We found that the total nocturnal sleep time and siesta were associated with the incidence of HCC (p < 0.001). The adjusted OR of HCC for the subjects with the shortest total nocturnal sleep time (≤ 6 hs) was 2.557 (p = 0.032), relative to those who slept between 6 and 8 h. The patients who slept ≥ 8 h experienced much lower risk. The adjusted OR of HCC for subjects with total nocturnal sleep time ≥ 8 h were 0.507 (p = 0.005) relative to those who slept 6–8 h. The subjects without siesta habit experienced a higher risk of HCC compared to those who with the siesta habit (adjusted OR 2.157, p = 0.001). These findings indicate that lack of nocturnal sleep is a potential risk factor for HCC in chronic HBV infected individuals whereas the siesta is a protective factor.

Keywords

Total nocturnal sleep time Siesta Hepatocellular carcinoma Chronic hepatitis B virus infection 

Abbreviations

HBV

Hepatitis B virus

HCV

Hepatitis C virus

HCC

Hepatocellular carcinoma

HBsAg

Hepatitis B surface antigen

HBeAg

Hepatitis B e antigen

OR

Odds ratio

CI

Confidence interval

CT

Computer tomography

MRI

Magnetic resonance imaging

ALT

Alanine transaminase

AST

Aspartate transaminase

TBIL

Total bilirubin

AFP

Alpha-fetoprotein

AKP

Alkaline phosphatase

ALB

Albumin

NAFLD

Nonalcoholic fatty liver disease

BMI

Body mass index

IFN

Interferon

Supplementary material

41105_2017_131_MOESM1_ESM.docx (21 kb)
Supplementary material 1 (DOCX 21 KB)

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Copyright information

© Japanese Society of Sleep Research 2017

Authors and Affiliations

  • Xu-Jin Liu
    • 1
    • 2
  • Fan Zhang
    • 3
  • Yuan Liu
    • 4
  • Yu-Chen Fan
    • 1
    • 2
  • Kai Wang
    • 1
    • 2
  1. 1.Department of HepatologyQilu Hospital of Shandong UniversityJinanChina
  2. 2.Institute of HepatologyShandong UniversityJinanChina
  3. 3.Department of Plastic SurgeryQilu Hospital of Shandong UniversityJinanChina
  4. 4.Department of RadiotherapyQilu Hospital of Shandong UniversityJinanChina

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