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Prevalence of restless legs syndrome in pregnant women: a meta-analysis

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Abstract

Restless legs syndrome is a neuromotor problem which is more common among pregnant women. Several studies have reported different prevalences for this disorder. Combining the results of these studies reveals reliable evidences for policymakers. This study aims to estimate the total prevalence of restless legs syndrome in pregnant women using meta-analysis. Different databanks (PubMed, Web of Sciences, EMBASE, EBSCO, Ovid, Scopus and Google Scholar) were searched using relevant keywords. After limiting the search strategy, reviewing the abstracts and full texts and quality assessment, eligible papers were selected for meta-analysis. Cochrane and I-squared indices were used to detect the degree of heterogeneity. The point prevalences were combined using random effects model. Studies that influenced the heterogeneity were detected using sensitivity analysis, while meta-regression models were applied to determine the factors that most affected the heterogeneity. Out of 26 eligible articles, 20.5% of pregnant women (95% confidence interval 16.5–24.2) were suffering from restless legs syndrome compared to 2.9% in Japan to 43.7% in Iran. Our meta-analysis showed that approximately one-fifth of pregnant women in the world have restless leg syndrome.

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Abbreviations

IRLSSG:

International Restless Legs Syndrome Study Group

RLS:

Restless legs syndrome

References

  1. Hensley JG, Shamim-Uzzaman Q. Prevalence of Willis–Ekbom disease/restless legs syndrome during pregnancy: a review. Open Sleep J. 2013;6(1):54–62.

    Article  Google Scholar 

  2. Oyieng’o DO, Kirwa K, Tong I, Martin S, Antonio Rojas-Suarez J, Bourjeily G. Restless legs symptoms and pregnancy and neonatal outcomes. Clin Ther. 2016;38(2):256–64.

    Article  PubMed  Google Scholar 

  3. Innes KE, Kandati S, Flack KL, Agarwal P, Selfe TK. The relationship of restless legs syndrome to history of pregnancy-induced hypertension. J Women’s Health. 2016;25(4):397–408.

    Article  Google Scholar 

  4. Gupta R, Dhyani M, Kendzerska T, Pandi-Perumal S, BaHammam A, Srivanitchapoom P, et al. Restless legs syndrome and pregnancy: prevalence, possible pathophysiological mechanisms and treatment. Acta Neurol Scand. 2015. doi:10.1111/ane.12520.

    PubMed  PubMed Central  Google Scholar 

  5. Srivanitchapoom P, Pandey S, Hallett M. Restless legs syndrome and pregnancy: a review. Parkinsonism Relat Disord. 2014;20(7):716–22.

    Article  PubMed  PubMed Central  Google Scholar 

  6. Ma S, Shang X, Guo Y, Liu G, Yang J, Xue R. Restless legs syndrome and hypertension in Chinese pregnant women. Neurol Sci. 2015;36(6):877–81.

    Article  PubMed  Google Scholar 

  7. Shang X, Yang J, Guo Y, Ma S, Jia Z, Xue R. Restless legs syndrome among pregnant women in China: prevalence and risk factors. Sleep Breath. 2015;19(3):1093–9.

    Article  PubMed  Google Scholar 

  8. Terzi H, Terzi R, Zeybek B, Ergenoglu M, Hacivelioglu S, Akdemir A, et al. Restless legs syndrome is related to obstructive sleep apnea symptoms during pregnancy. Sleep Breath. 2015;19(1):73–8.

    Article  PubMed  Google Scholar 

  9. Liu G, Li L, Zhang J, Xue R, Zhao X, Zhu K, et al. Restless legs syndrome and pregnancy or delivery complications in China: a representative survey. Sleep Med. 2016;17:158–62.

    Article  CAS  PubMed  Google Scholar 

  10. Hennessy MD, De La Torre FA. Heredity of restless legs syndrome in a pregnant population. J Obstet Gynaecol Neonat Nurs. 2013;42(6):737–48.

    Article  Google Scholar 

  11. Alves DAG, de Carvalho LBC, de Morais JF, do Prado GF. Restless legs syndrome during pregnancy in Brazilian women. Sleep Med. 2010;11(10):1049–54.

    Article  PubMed  Google Scholar 

  12. Meharaban Z, Yahya S, Sadegniiat K. Restless legs syndrome during pregnancy and preterm birth in women referred to health centers of Ardabil. Iran Red Crescent Med J. 2015;17:12.

    Article  Google Scholar 

  13. Patrick L. Restless legs syndrome: pathophysiology and the role of iron and folate. Altern Med Rev. 2007;12(2):101–13.

    PubMed  Google Scholar 

  14. Dzaja A, Wehrle R, Lancel M, Pollmächer T. Elevated es-tradiol plasma levels in women with restless legs during pregnancy. Sleep. 2009;32(2):169–74.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Pereira JC Jr, Pradella-Hallinan M, Pessoa HdL. Imbalance between thyroid hormones and the dopaminergic system might be central to the pathophysiology of restless legs syndrome: a hypothesis. Clinics. 2010;65(5):547–54.

    Article  Google Scholar 

  16. Tunç T, Karadağ YS, Doğulu F, İnan LE. Predisposing factors of restless legs syndrome in pregnancy. Mov Disord. 2007;22(5):627–31.

    Article  PubMed  Google Scholar 

  17. Moosazadeh M, Nekoei-Moghadam M, Aliram-Zany M, Amiresmaili M. Identification of Mutation of glucose-6-phosphate dehy-drogenase (G6PD) in Iran: meta-analysis study. Iran J Public Health. 2013;42(9):1007.

    CAS  PubMed  PubMed Central  Google Scholar 

  18. Moosazadeh M, Amiresmaili M, Aliramezany M. Prevalence of G6PD deficiency in Iran, a mata-analysis. Acta Med Iran. 2014;52(4):256.

    PubMed  Google Scholar 

  19. Moosazadeh M. Meta‑analysis of prevalence of smoking in 15–64‑year‑old population of west of Iran. Int J Prev Med. 2013;1(1):1108–14.

    Google Scholar 

  20. von Elm E, Altman DG, Egger M, Pocock SJ, Gotzsche PC, Vandenbroucke JP, et al. The strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies. Prev Med. 2007;45(4):247–51.

    Article  Google Scholar 

  21. Harano S, Ohida T, Kaneita Y, Yokoyama E, Tamaki T, Takemura S, et al. Prevalence of restless legs syndrome with pregnancy and the relationship with sleep disorders in the Japanese large population. Sleep Biol Rhythm. 2008;6(2):102–9.

    Article  Google Scholar 

  22. Wesstrom J, Skalkidou A, Manconi M, Fulda S, Sundstrom-Poromaa I. Pre-pregnancy restless legs syndrome (Willis-Ekbom disease) is associated with perinatal depression. J Clin Sleep Med. 2014;10(5):527–33.

    PubMed  PubMed Central  Google Scholar 

  23. Balendran J, Champion D, Jaaniste T, Welsh A. A common sleep disorder in pregnancy: restless legs syndrome and its predictors. Aust N Z J Obstet Gynaecol. 2011;51(3):262–4.

    Article  PubMed  Google Scholar 

  24. Vahdat M, Sariri E, Miri S, Rohani M, Kashanian M, Sabet A, et al. Prevalence and associated features of restless legs syndrome in a population of Iranian women during pregnancy. Int J Gynaecol Obstet. 2013;123(1):46–9.

    Article  PubMed  Google Scholar 

  25. Sarberg M, Josefsson A, Wirehn AB, Svanborg E. Restless legs syndrome during and after pregnancy and its relation to snoring. Acta Obstet Gynaecol Scand. 2012;91(7):850–5.

    Article  Google Scholar 

  26. Chen PH, Liou KC, Chen CP, Cheng SJ. Risk factors and prevalence rate of restless legs syndrome among pregnant women in Taiwan. Sleep Med. 2012;13(9):1153–7.

    Article  PubMed  Google Scholar 

  27. Sikandar R, Khealani BA, Wasay M. Predictors of restless legs syndrome in pregnancy: a hospital based cross sectional survey from Pakistan. Sleep Med. 2009;10(6):676–8.

    Article  PubMed  Google Scholar 

  28. Ismailogullari S, Ozturk A, Mazicioglu MM, Serin S, Gultekin M, Aksu M. Restless legs syndrome and pregnancy in Kayseri, Turkey: a hospital based survey. Sleep Biol Rhythm. 2010;8(2):137–43.

    Article  Google Scholar 

  29. Facco FL, Kramer J, Ho KH, Zee PC, Grobman WA. Sleep disturbances in pregnancy. Obstet Gynaecol. 2010;115(1):77–83.

    Article  Google Scholar 

  30. Hubner A, Krafft A, Gadient S, Werth E, Zimmermann R, Bassetti CL. Characteristics and determinants of restless legs syndrome in pregnancy: a prospective study. Neurology. 2013;80(8):738–42.

    Article  PubMed  Google Scholar 

  31. Mindell JA, Cook RA, Nikolovski J. Sleep patterns and sleep disturbances across pregnancy. Sleep Med. 2015;16(4):483–8.

    Article  PubMed  Google Scholar 

  32. Manconi M, Govoni V, De Vito A, Economou NT, Cesnik E, Casetta I, et al. Restless legs syndrome and pregnancy. Neurology. 2004;63(6):1065–9.

    Article  CAS  PubMed  Google Scholar 

  33. Minar M, Habanova H, Rusnak I, Planck K, Valkovic P. Prevalence and impact of restless legs syndrome in pregnancy. Neuro Endocrinol Lett. 2013;34(5):366–71.

    PubMed  Google Scholar 

  34. Suzuki K, Ohida T, Sone T, Takemura S, Yokoyama E, Miyake T, et al. The prevalence of restless legs syndrome among pregnant women in Japan and the relationship between restless legs syndrome and sleep problems. Sleep. 2003;26(6):673–7.

    PubMed  Google Scholar 

  35. Uglane MT, Westad S, BACKE B. Restless legs syndrome in pregnancy is a frequent disorder with a good prognosis. Acta Obstet Gynaecol Scand. 2011;90(9):1046–8.

    Article  Google Scholar 

  36. Ramirez JO, Cabrera SA, Hidalgo H, Cabrera SG, Linnebank M, Bassetti CL, et al. Is preeclampsia associated with restless legs syndrome? Sleep Med. 2013;14(9):894–6.

    Article  CAS  PubMed  Google Scholar 

  37. Neau JP, Marion P, Mathis S, Julian A, Godeneche G, Larrieu D, et al. Restless legs syndrome and pregnancy: follow-up of pregnant women before and after delivery. Eur Neurol. 2010;64(6):361–6.

    Article  PubMed  Google Scholar 

  38. Kemlink D, Plchova L, Srutkova Z, Pavlickova J, Sonka K, Parizek A. Restless legs syndrome during pregnancy in Czech women. Sleep Med. 2013;14:e167.

    Article  Google Scholar 

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Authors and Affiliations

  1. Mazandaran University of Medical Sciences, Sari, Iran

    Atekeh Hadinezhad Makrani, Motahareh Kheradmand, Zahra Foroughi & Fereshteh Farshidi

  2. Department of Community Medicine, Zabol University of Medical Sciences, Zabol, Iran

    Mahdi Afshari

  3. Molecular and Cell Biology Research Center, Mazandaran University of Medical Sciences, Sari, Iran

    Marayam Ghajar

  4. Health Sciences Research Center, Addiction Institute, Mazandaran University of Medical Sciences, Farahabad road, Sari, Iran

    Mahmood Moosazadeh

  5. Obstetrics and Gynecology Department, Mehr Hospital, Borazjan, Iran

    Kefayat Chaman-Ara

  6. Healthcare Management Department, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

    Mohammad Amin Bahrami

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  1. Atekeh Hadinezhad Makrani
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Correspondence to Mahmood Moosazadeh.

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Makrani, A.H., Afshari, M., Kheradmand, M. et al. Prevalence of restless legs syndrome in pregnant women: a meta-analysis. Sleep Biol. Rhythms 16, 3–10 (2018). https://doi.org/10.1007/s41105-017-0126-6

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  • DOI: https://doi.org/10.1007/s41105-017-0126-6

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