A new light source (Valkee©) does not alter sleep–wake parameters and does not improve mood in phase delayed subjects

Abstract

Not much evidence exists concerning the effects on sleep and mood of transcranial bright light. In this study, 50 students, all with wake-up time 9:00 a.m. or later in weekends/free days, participated in a double-blind placebo-controlled experiment comparing the effects of bright light (n = 27; 8.0 lm) and placebo (n = 23; 0.1 lm). Data collection consisted of sleep assessment, with both sleep diaries and actigraphy. In addition, the Fatigue Severity Scale and the Profile of Mood States (POMS) were administered. Following 1 week of baseline recording, the therapy was initiated, aiming to phase advance the sleep–wake period. The therapy lasted for 2 weeks and consisted of gradually advancing daily light exposure of 12 min’ transcranial bright light. Subjects in the two conditions did not change differently from baseline to post-treatment on any sleep parameters. A significant condition × time interaction was found for one of six subscales (vigor–activity) of the POMS, suggesting a more favorable development from baseline to post-treatment in the placebo compared to the bright light condition. No differences in terms of side-effects were reported between conditions. It is concluded that transcranial bright light, at times where conventional light therapy has phase-advancing properties, did not influence any sleep parameters differently than placebo. Transcranial bright light was associated with a less favorable development from baseline to post-treatment on one mood parameter compared to placebo.

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References

  1. 1.

    Czeisler CA, Duffy JF, Shanahan TL, Brown EN, Mitchell JF, Rimmer DW, et al. Stability, precision, and near-24-hour period of the human circadian pacemaker. Science. 1999;284:2177–81.

    Article  CAS  PubMed  Google Scholar 

  2. 2.

    Johnson CH, Elliott JA, Foster R. Entrainment of circadian programs. Chronobiol Int. 2003;20:741–74.

    Article  PubMed  Google Scholar 

  3. 3.

    Khalsa SBS, Jewett ME, Cajochen C, Czeisler CA. A phase response curve to single bright light pulses in human subjects. J Physiol (Lond). 2003;549:945–52.

    Article  CAS  Google Scholar 

  4. 4.

    Rajaratnam SM, Arendt J. Health in a 24-h society. Lancet. 2001;358:999–1005.

    Article  CAS  PubMed  Google Scholar 

  5. 5.

    Bjorvatn B, Pallesen S. A practical approach to circadian rhythm sleep disorders. Sleep Med Rev. 2009;13:47–60.

    Article  PubMed  Google Scholar 

  6. 6.

    Folkard S, Monk TH. Shiftwork and performance. Hum Factors. 1979;21:489–92.

    Google Scholar 

  7. 7.

    Hattar S, Liao HW, Takao M, Berson DM, Yau KW. Melanopsin-containing retinal ganglion cells: architecture, projections, and intrinsic photosensitivity. Science. 2002;295:1065–70.

    PubMed Central  Article  CAS  PubMed  Google Scholar 

  8. 8.

    Terman M, Terman JS. Light therapy. In: Kryger MH, Roth T, Dement WC, editors. Principles and practice of sleep medicine. 5th ed. St. Louis: Elsevier Saunders; 2011. p. 1682–95.

    Google Scholar 

  9. 9.

    Ruger M, St Hilaire MA, Brainard GC, Khalsa SBS, Kronauer RE, Czeisler CA, et al. Human phase response curve to a single 6.5 h pulse of short-wavelength light. J Physiol (Lond). 2013;591:353–63.

    Article  CAS  Google Scholar 

  10. 10.

    Cole RJ, Smith JS, Alcala YC, Elliott JA, Kripke DF. Bright-light mask treatment of delayed sleep phase syndrome. J Biol Rhythms. 2002;17:89–101.

    Article  PubMed  Google Scholar 

  11. 11.

    Lack L, Bramwell T, Wright H, Kemp K. Morning blue light can advance the melatonin rhythm in mild delayed sleep phase syndrome. Sleep Biol Rhythms. 2007;5:78–80.

    Google Scholar 

  12. 12.

    Sharkey KM, Carskadon MA, Figueiro MG, Zhu Y, Rea MS. Effects of an advanced sleep schedule and morning short wavelength light exposure on circadian phase in young adults with late sleep schedules. Sleep Med. 2011;12:685–92.

    PubMed Central  Article  PubMed  Google Scholar 

  13. 13.

    Terman M, Terman JS. Circadian rhythm phase advance with dawn simulation and negative air ionization for seasonal affective disorder. Am J Psychiatry. 2006;163:2126–33.

    Article  PubMed  Google Scholar 

  14. 14.

    Boulos Z, Macchi MM, Sturchler MP, Stewart KT, Brainard GC, Suhner A, et al. Light visor treatment for jet lag after westward travel across six time zones. Aviat Space Environ Med. 2002;73:953–63.

    PubMed  Google Scholar 

  15. 15.

    Terman M, Terman JS. Light therapy for seasonal and nonseasonal depression: efficacy, protocol, safety, and side effects. CNS Spectr. 2005;10:647–63.

    Article  PubMed  Google Scholar 

  16. 16.

    Ruger M, Gordijn MCM, Beersma DGM, de Vries B, Daan S. Acute and phase-shifting effects of ocular and extraocular light in human circadian physiology. J Biol Rhythms. 2003;18:409–19.

    Article  PubMed  Google Scholar 

  17. 17.

    Starck T, Nissilä J, Aunio A, Abou-Elseoud A, Remes J, Nikkinen J, et al. Stimulating brain tissue with bright light alters functional connectivity in brain at the resting state. World J Neurosci. 2012;2:81–90.

    Article  Google Scholar 

  18. 18.

    Timonen M, Nissila J, Liettu A, Jokelainen J, Jurvelin H, Aunio A, et al. Can transcranial brain-targeted bright light treatment via ear canals be effective in relieving symptoms in seasonal affective disorder? A pilot study. Med Hypotheses. 2012;78:511–5.

    Article  PubMed  Google Scholar 

  19. 19.

    Jurvelin H, Takala T, Nissila J, Timonen M, Ruger M, Jokelainen J, et al. Transcranial bright light treatment via the ear canals in seasonal affective disorder: a randomized, double-blind dose-response study. BMC Psychiatry. 2014;14:article no. 288.

  20. 20.

    Bromundt V, Frey S, Odermatt J, Cajochen C. Extraocular light via the ear canal does not acutely affect human circadian physiology, alertness and psychomotor vigilance performance. Chronobiol Int. 2014;31:343–8.

    Article  PubMed  Google Scholar 

  21. 21.

    Burgess HJ, Eastman CI. The dim light melatonin onset following fixed and free sleep schedules. J Sleep Res. 2005;14:229–37.

    Article  PubMed  Google Scholar 

  22. 22.

    Wright H, Lack L, Bootzin RR. Relationships between dim light melatonin onset and the timing of sleep in sleep onset insomniacs. Sleep Biol Rhythms. 2006;4:78–80.

    Article  Google Scholar 

  23. 23.

    Benloucif S, Guico MJ, Reid KJ, Wolfe LF, L’Hermite-Baleriaux M, Zee PC. Stability of melatonin and temperature as circadian phase markers and their relation to sleep times in humans. J Biol Rhythms. 2005;20:178–88.

    Article  CAS  PubMed  Google Scholar 

  24. 24.

    Saxvig IW, Pallesen S, Wilhelmsen-Langeland A, Molde H, Bjorvatn B. Prevalence and correlates of delayed sleep phase in high school students. Sleep Med. 2012;13:193–9.

    Article  PubMed  Google Scholar 

  25. 25.

    Short MA, Gradisar M, Lack LC, Wright HR, Dohnt H. The sleep patterns and well-being of Australian adolescents. J Adolesc. 2013;36:103–10.

    Article  PubMed  Google Scholar 

  26. 26.

    Roenneberg T, Wirz-Justice A, Merrow M. Life between clocks: daily temporal patterns of human chronotypes. J Biol Rhythms. 2003;18:80–90.

    Article  PubMed  Google Scholar 

  27. 27.

    Hirschfeld RMA, Williams JBW, Spitzer RL, Calabrese JR, Flynn L, Keck PE, et al. Development and validation of a screening instrument for bipolar spectrum disorder: the mood disorder questionnaire. Am J Psychiatry. 2000;157:1873–5.

    Article  CAS  PubMed  Google Scholar 

  28. 28.

    Krupp LB, Larocca NG, Muirnash J, Steinberg AD. The Fatigue Severity Scale—application to patients with multiple-sclerosis and systemic lupus-erythematosus. Arch Neurol. 1989;46:1121–3.

    Article  CAS  PubMed  Google Scholar 

  29. 29.

    Norcross JC, Guadagnoli E, Prochaska JO. Factor structure of the Profile of Mood States (POMS)—2 partial replications. J Clin Psychol. 1984;40:1270–7.

    Article  CAS  PubMed  Google Scholar 

  30. 30.

    Orne MT. On the social psychology of the psychological experiment: with particular reference to demand characteristics and their implications. Am Psychol. 1962;17:776–83.

    Article  Google Scholar 

  31. 31.

    Levitt AJ, Joffe RT, Moul DE, Lam RW, Teicher MH, Lebegue B, et al. Side-effects of light therapy in seasonal affective-disorder. Am J Psychiatry. 1993;150:650–2.

    Article  CAS  PubMed  Google Scholar 

  32. 32.

    Sadeh A. The role and validity of actigraphy in sleep medicine: an update. Sleep Med Rev. 2011;15:259–67.

    Article  PubMed  Google Scholar 

  33. 33.

    Faul F, Erdfelder E, Lang AG, Buchner A. G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods. 2007;39:175–91.

    Article  PubMed  Google Scholar 

  34. 34.

    Saxvig IW, Wilhelmsen-Langeland A, Pallesen S, Vedaa O, Nordhus IH, Bjorvatn B. A randomized controlled trial with bright light and melatonin for delayed sleep phase disorder: effects on subjective and objective sleep. Chronobiol Int. 2014;31:72–86.

    Article  CAS  PubMed  Google Scholar 

  35. 35.

    Gradisar M, Dohnt H, Gardner G, Paine S, Starkey K, Menne A, et al. A randomized controlled trial of cognitive-behavior therapy plus bright light therapy for adolescent delayed sleep phase disorder. Sleep. 2011;34:1671–80.

    PubMed Central  PubMed  Google Scholar 

  36. 36.

    Jurvelin H, Takala T, Heberg L, Nissila J, Ruger M, Leppaluoto J, et al. Transcranial bright light exposure via ear canals does not suppress nocturnal melatonin in healthy adults—a single-blind, sham-controlled, crossover trial. Chronobiol Int. 2014;31:855–60.

    Article  CAS  PubMed  Google Scholar 

  37. 37.

    Lewy AJ, Wehr TA, Goodwin FK, Newsome DA, Markey SP. Light suppresses melatonin secretion in humans. Science. 1980;210:1267–9.

    Article  CAS  PubMed  Google Scholar 

  38. 38.

    Jurvelin H, Jokelainen J, Takala T. Transcranial bright light and symptoms of jet lag: a randomized, placebo-controlled trial. Aerosp Med Hum Perform. 2015;86(4):1–8.

    Article  Google Scholar 

  39. 39.

    Magnusson A, Partonen T. The diagnosis, symptomatology, and epidemiology of seasonal affective disorder. CNS Spectr. 2005;10:625–34.

    PubMed  Google Scholar 

  40. 40.

    Haimov I, Arendt J. The prevention and treatment of jet lag. Sleep Med Rev. 1999;3:229–40.

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgments

The authors received 12,000 Euros from Valkee® covering expenses related to the conduct of the present study.

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Correspondence to Ståle Pallesen.

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Pallesen, S., Nødtvedt, Ø., Saxvig, I.W. et al. A new light source (Valkee©) does not alter sleep–wake parameters and does not improve mood in phase delayed subjects. Sleep Biol. Rhythms 14, 97–105 (2016). https://doi.org/10.1007/s41105-015-0027-5

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Keywords

  • Transcranial bright light
  • Sleep–wake rhythm
  • Mood
  • Randomized controlled trial