Sleep and Biological Rhythms

, Volume 14, Issue 1, pp 55–62 | Cite as

Circadian clock gene variants and insomnia, sleepiness, and shift work disorder

  • Eirunn Thun
  • S. Le Hellard
  • T. M. Osland
  • B. Bjorvatn
  • B. E. Moen
  • N. Magerøy
  • V. M. Steen
  • S. Giddaluru
  • H.-R. Brattbakk
  • S. Pallesen
Original Article

Abstract

Shift workers often experience circadian misalignment and problems adjusting adequately to their work schedules, which is manifested in the high prevalence rates of shift work disorder, insomnia and sleepiness in this group of workers compared to day workers. However, there exist large inter-individual differences in tolerance to shift work. We investigated whether frequency variation in single nucleotide polymorphisms capturing genetic variation in genes involved in the regulation of circadian rhythms (clock genes) was associated with insomnia, sleepiness, and shift work disorder in a sample of Norwegian nurses employed in various work schedules. Saliva samples from 691 female nurses participating in “the Survey on Shift work, Sleep and Health” were analysed for associations between genetic variations in clock genes and the nurses’ survey responses. A total of 662 single nucleotide polymorphisms were analysed. After multiple testing correction, we did not observe any statistically significant associations between the genetic variants and insomnia, sleepiness, or shift work disorder.

Keywords

Clock genes Single nucleotide polymorphisms Insomnia Sleepiness Shift work disorder 

Supplementary material

41105_2015_23_MOESM1_ESM.xlsx (150 kb)
Supplementary material 1 (XLSX 150 kb)

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Copyright information

© Japanese Society of Sleep Research 2015

Authors and Affiliations

  • Eirunn Thun
    • 1
  • S. Le Hellard
    • 2
    • 3
  • T. M. Osland
    • 2
    • 3
  • B. Bjorvatn
    • 4
    • 5
  • B. E. Moen
    • 6
  • N. Magerøy
    • 7
  • V. M. Steen
    • 2
    • 3
  • S. Giddaluru
    • 2
    • 3
  • H.-R. Brattbakk
    • 2
    • 3
  • S. Pallesen
    • 1
    • 4
  1. 1.Department of Psychosocial ScienceUniversity of BergenBergenNorway
  2. 2.Department of Clinical ScienceKG Jebsen Centre for Psychosis Research, The Norwegian Centre for Mental Disorders Research (NORMENT), University of BergenBergenNorway
  3. 3.Dr. Einar Martens Research Group for Biological PsychiatryCenter for Medical Genetics and Molecular Medicine, Haukeland University HospitalBergenNorway
  4. 4.Norwegian Competence Center for Sleep Disorders, Haukeland University HospitalBergenNorway
  5. 5.Department of Global Public Health and Primary CareUniversity of BergenBergenNorway
  6. 6.Centre for International HealthUniversity of BergenBergenNorway
  7. 7.Department of Occupational MedicineHaukeland University HospitalBergenNorway

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