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Transition-Metal Catalyzed Synthesis of Pyrimidines: Recent Advances, Mechanism, Scope and Future Perspectives

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Abstract

Pyrimidine is a pharmacologically important moiety that exhibits diverse biological activities. This review reflects the growing significance of transition metal-catalyzed reactions for the synthesis of pyrimidines (with no discussion being made on the transition metal-catalyzed functionalization of pyrimidines). The effect of different catalysts on the selectivity/yields of pyrimidines and catalyst recyclability (wherever applicable) are described, together with attempts to illustrate the role of the catalyst through mechanisms. Although several methods have been researched for synthesizing this privileged scaffold, there has been a considerable push to expand transition metal-catalyzed, sustainable, efficient and selective synthetic strategies leading to pyrimidines. The aim of the authors with this update (2017–2023) is to drive the designing of new transition metal-mediated protocols for pyrimidine synthesis.

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All data used in this review were retrieved from the cited references.

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Acknowledgements

V.K. Maikhuri and B. K. Singh are grateful to the Institution of Eminence, University of Delhi for providing financial support to strengthen research and development. D. Mathur is grateful for the Navdhara Research Grant by Daulat Ram College, University of Delhi for providing funding assistance to support research. We thank several colleagues and co-workers mentioned in the Reference List from our Laboratories for their collaboration, dedication and hard work.

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Authors and Affiliations

  1. Bioorganic Laboratory, Department of Chemistry, University of Delhi, Delhi, 110007, India

    Vipin K. Maikhuri, Divya Mathur, Virinder S. Parmar & Brajendra K. Singh

  2. Department of Chemistry, Daulat Ram College, University of Delhi, Delhi, 110007, India

    Divya Mathur

  3. Department of Chemistry, Maitreyi College, University of Delhi, Delhi, 110021, India

    Ankita Chaudhary

  4. Department of Chemistry, R.D.S College, B.R.A. Bihar University, Muzaffarpur, India

    Rajesh Kumar

  5. Nanoscience Program, CUNY Graduate Center and Department of Chemistry, City College & Medgar Evers College, The City University of New York, 160 Convent Avenue, New York, NY, 10031, USA

    Virinder S. Parmar

  6. Institute of Click Chemistry Research and Studies, Amity University, Noida, Uttar Pradesh, 201303, India

    Virinder S. Parmar

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  1. Vipin K. Maikhuri
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Correspondence to Divya Mathur.

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We dedicate this article to the fond memory of our long-term friend, collaborator, colleague and teacher, the (late) Professor Ashok K. Prasad, whose continued inspiration over the past several decades has shaped the careers of many young scientists.

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Maikhuri, V.K., Mathur, D., Chaudhary, A. et al. Transition-Metal Catalyzed Synthesis of Pyrimidines: Recent Advances, Mechanism, Scope and Future Perspectives. Top Curr Chem (Z) 382, 4 (2024). https://doi.org/10.1007/s41061-024-00451-2

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