Cross-Dehydrogenative Coupling Reactions Between P(O)–H and X–H (X = S, N, O, P) Bonds

  • Akram Hosseinian
  • Sepideh Farshbaf
  • Leila Zare FekriEmail author
  • Mohammad Nikpassand
  • Esmail Vessally


P(O)–X (X = S, N, O, P) bond-containing compounds have extensive application in medicinal chemistry, agrochemistry, and material chemistry. These useful organophosphorus compounds also have many applications in organic synthesis. In light of the importance of titled compounds, there is continuing interest in the development of synthetic methods for P(O)–X bonds construction. In the last 4 years, the direct coupling reaction of P(O)–H compounds with thiols, alcohols, and amines/amides has received much attention because of the atom-economic character. This review aims to give an overview of new developments in cross-dehydrogenative coupling reactions between P(O)–H and X–H (X = S, N, O, P) bonds, with special emphasis on the mechanistic aspects of the reactions.


Cross-dehydrogenative couplings Phosphorylation P(O)–H bond P(O)–S bond P(O)–O bond P(O)–S bond P(O)–P(O) bond 



The authors wish to acknowledge Dr. Khadijeh Didehban and Azam Monfared for their suitable comments on our paper.


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Akram Hosseinian
    • 1
  • Sepideh Farshbaf
    • 2
  • Leila Zare Fekri
    • 3
    Email author
  • Mohammad Nikpassand
    • 4
  • Esmail Vessally
    • 3
  1. 1.Department of Engineering Science, College of EngineeringUniversity of TehranTehranIran
  2. 2.Department of Chemistry and Center for Photochemical SciencesBowling Green State UniversityBowling GreenUSA
  3. 3.Department of ChemistryPayame Noor UniversityTehranIran
  4. 4.Department of Chemistry, Rasht BranchIslamic Azad UniversityRashtIran

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