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Topics in Current Chemistry

, 376:5 | Cite as

Analysis of US FDA-Approved Drugs Containing Sulfur Atoms

Review
Part of the following topical collections:
  1. Sulfur Chemistry

Abstract

In this review, we discuss all sulfur-containing FDA-approved drugs and their structures. The second section of the review is dedicated to structural analysis and is divided into 14 subsections, each focusing on one type of sulfur-containing moiety. A concise graphical representation of each class features drugs that are organized on the basis of structural similarity, evolutionary relevance, and medical indication. This review offers a unique and comprehensive overview of the structural features of all sulfur-containing FDA-approved drugs to date.

Keywords

Sulfonamide Thioether Sulfoxide Sulfone Sulfate Sulfur heterocycle 

Abbreviations

6-APA

6-Aminopenicillanic acid

ADP

Adenosine diphosphate

cGMP

Cyclic guanosine monophosphate

COX-2

Cyclooxygenase-2

GERD

Gastroesophageal reflux disease

GPCR

G protein-coupled receptor

HIV

Human immunodeficiency virus

mRNA

Messenger RNA

NSAID

Nonsteroidal anti-inflammatory drugs

SMN1

Survival motor neuron 1

SMN2

Survival motor neuron 2

PBP-3

Penicillin binding protein 3

P2Y12

A type of purinergic receptor

PDE5

Phosphodiesterase type 5

PET

Positron emission tomography

PPI

Proton pump inhibitor

US FDA

United States Food and Drug Administration

Notes

Acknowledgements

The funding was provided by National Science Foundation (Grant no. CHE-1565500).

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Chemistry and BiochemistryUniversity of ArizonaTucsonUSA
  2. 2.Department of Pharmacology and ToxicologyUniversity of ArizonaTucsonUSA

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