Topics in Current Chemistry

, 376:5 | Cite as

Analysis of US FDA-Approved Drugs Containing Sulfur Atoms

Part of the following topical collections:
  1. Sulfur Chemistry


In this review, we discuss all sulfur-containing FDA-approved drugs and their structures. The second section of the review is dedicated to structural analysis and is divided into 14 subsections, each focusing on one type of sulfur-containing moiety. A concise graphical representation of each class features drugs that are organized on the basis of structural similarity, evolutionary relevance, and medical indication. This review offers a unique and comprehensive overview of the structural features of all sulfur-containing FDA-approved drugs to date.


Sulfonamide Thioether Sulfoxide Sulfone Sulfate Sulfur heterocycle 



6-Aminopenicillanic acid


Adenosine diphosphate


Cyclic guanosine monophosphate




Gastroesophageal reflux disease


G protein-coupled receptor


Human immunodeficiency virus


Messenger RNA


Nonsteroidal anti-inflammatory drugs


Survival motor neuron 1


Survival motor neuron 2


Penicillin binding protein 3


A type of purinergic receptor


Phosphodiesterase type 5


Positron emission tomography


Proton pump inhibitor


United States Food and Drug Administration



The funding was provided by National Science Foundation (Grant no. CHE-1565500).


  1. 1.
    Ilardi EA, Vitaku E, Njardarson JT (2014) J Med Chem 57:2832–2842CrossRefGoogle Scholar
  2. 2.
    Sprague JM (1958) Ann NY Acad Sci 71:328–342CrossRefGoogle Scholar
  3. 3.
    Maren TH (1976) Annu Rev Pharmacol Toxicol 16:309–327CrossRefGoogle Scholar
  4. 4.
    Fitzgerald D (2005) Dialogues Cardiovasc Med 10:175–182Google Scholar
  5. 5.
    Mulder H, Shopman W Sr, van der Lely AJ (1991) Eur J Clin Pharmacol 1991(40):379–381CrossRefGoogle Scholar
  6. 6.
    Meyer M, Chudziak F, Schwanstecher C et al (1999) Br J Pharmacol 128:27–34CrossRefGoogle Scholar
  7. 7.
    Inagaki N, Gonoi T, Clement JP et al (1996) Neuron 16:1011–1017CrossRefGoogle Scholar
  8. 8.
    Tréfouël JT, Nitti F, Bovet D (1935) CR Soc Biol 120:756Google Scholar
  9. 9.
    Seydel JK (1968) J Pharm Sci 57:1455–1478CrossRefGoogle Scholar
  10. 10.
    Lemke TL, Williams DA, Roche VF, Zito SW (2013) Foye’s medicinal chemistry, 7th edn. Lippincott Williams & Wilkins, BaltimoreGoogle Scholar
  11. 11.
    Corbin JD, Beasley A, Blount MA, Francis SH (2004) Neurochem Int 45:859–863CrossRefGoogle Scholar
  12. 12.
    Nagashima H (2002) J Biol Chem 277:50439–50449CrossRefGoogle Scholar
  13. 13.
    Abraham EP, Newton GGF (1961) Biochem J 79:377–393CrossRefGoogle Scholar
  14. 14.
    Long KS, Hansen LH, Jakobsen L, Vester B (2006) Antimicrob Agents Chemother 50:1458–1462CrossRefGoogle Scholar
  15. 15.
    Oliphant CS, Doby JB, Das K (2010) Curr Vasc Pharmacol 8:93–101CrossRefGoogle Scholar
  16. 16.
    Elion G (1989) Science 244:4900CrossRefGoogle Scholar
  17. 17.
    Nag K, Singh DR, Shetti AN, Kumar H, Sivashanmugam T, Parthasarathy S (2013) Anesth Essays Res 7:302–306CrossRefGoogle Scholar
  18. 18.
    Corey EJ, Gin DY, Kania RS (1996) J Am Chem Soc 38:9202–9203CrossRefGoogle Scholar
  19. 19.
    Blanchet PJ (1999) Can J Neurol Sci 26(Suppl 2):S21–S26CrossRefGoogle Scholar
  20. 20.
    Horvath J, Fross RD, Kleiner-Fisman G et al (2004) Mov Disord 19:656–662CrossRefGoogle Scholar
  21. 21.
    Chang W, Weber M, Breier MR, Saint Marie RL, Hines SR, Swerdlow NR (2012) Brain Res 1437:69–76CrossRefGoogle Scholar
  22. 22.
    Markowitz M, Saag M, Powderly WG et al (1995) N Eng J Med 333:1534–1539CrossRefGoogle Scholar
  23. 23.
    Humphries TJ, Merritt GJ (1999) Aliment Pharmacol Ther 13:18–26CrossRefGoogle Scholar
  24. 24.
    Miller RG, Mitchell JD, Moore DH (2012) Cochrane Database Syst Rev 3:CD001447Google Scholar
  25. 25.
    Ding Z, Kim S, Dorsam RT et al (2003) Blood 101:3908–3914CrossRefGoogle Scholar
  26. 26.
    Wallentin L (2009) Eur Heart J 30:1964–1977CrossRefGoogle Scholar
  27. 27.
    Horn AS, Snyder SH (1971) Proc Natl Acad Sci 68:2325–2328CrossRefGoogle Scholar
  28. 28.
    Massie SP (1954) Chem Rev 54:797–833CrossRefGoogle Scholar
  29. 29.
    Shen WW (1999) Compr Psychiatry 40:407CrossRefGoogle Scholar
  30. 30.
    Binchi MT (2010) Med Hypotheses 74(2):297–300CrossRefGoogle Scholar
  31. 31.
    Bovet D, Stauo AM (1937) CR Biol 124:547–549Google Scholar
  32. 32.
    Delay J, Deniker P, Harl J (1952) Ann Med Psychol 110:112–117Google Scholar
  33. 33.
    Zhang P, Li J, Han Y et al (2010) Rheumatol Int 30:713–718CrossRefGoogle Scholar
  34. 34.
    Andersson T, Weidolf L (2008) Clin Drug Investig 28:263–279CrossRefGoogle Scholar
  35. 35.
    Agranat I, Caner H, Caldwell J (2002) Nat Rev Drug Discov 1:753–768CrossRefGoogle Scholar
  36. 36.
    Shin JM, Cho YM, Sachs G (2004) J Am Chem Soc 12:7800–7811CrossRefGoogle Scholar
  37. 37.
    Besancon M, Simon A, Sachs G, Shin JM (1997) J Biol Chem 272:22438–22446CrossRefGoogle Scholar
  38. 38.
    Coulthard SA, Hogarth LA, Little M et al (2002) Mol Pharmacol 62:1CrossRefGoogle Scholar
  39. 39.
    Cresciolo C, Cosmi L, Borgogni E et al (2007) J Endocrinol 195:145–155CrossRefGoogle Scholar
  40. 40.
    Kim TH, Jeong JW, Lee KR, Ahn S, Kim S, Koo TS (2015) Arch Pharm Res 38:2076–2082CrossRefGoogle Scholar
  41. 41.
    Taurog A (1976) Endocrinology 98:1031–1046CrossRefGoogle Scholar
  42. 42.
    Jacobsen E, Larsen V (1949) Acta Pharmacol Toxicol 5:285–291CrossRefGoogle Scholar
  43. 43.
    Bieder A, Brunel P, Mazeau L (1966) Ann Pharm France 24:493–500Google Scholar
  44. 44.
    Caceres NE, Harris NB, Wellehan JF et al (1997) J Bacteriol 179:5046–5055CrossRefGoogle Scholar
  45. 45.
    Ijaz N, Fitzgerald D (2017) Br J Hosp Med 2:C88–C91CrossRefGoogle Scholar
  46. 46.
    Steudel R, Laitinen R (1982) Top Curr Chem 102:177–197CrossRefGoogle Scholar
  47. 47.
    Karr S (2017) Am J Manag Care 23:S139–S1478Google Scholar
  48. 48.
    Ottesen EW (2017) Transl Neurosci 8:1–6CrossRefGoogle Scholar
  49. 49.
    Seeling A, Oelschläger H, Rothley D (2000) Pharmazie 55:293–296Google Scholar
  50. 50.
    Diener HC, Limmroth V (1999) Opin Neurol 12:261–267CrossRefGoogle Scholar
  51. 51.
    Medeiros GF, Mendes A, Castro RAB, Baú EC, Nader B, Dietrich CP (2000) Biochim Biophys Acta Gen Subj 1475:287–294CrossRefGoogle Scholar
  52. 52.
    Ueda H, Nakajima H, Horim Y et al (1994) J Antibiot 3:301–310CrossRefGoogle Scholar
  53. 53.
    Li KW, Wu J, Simon JA (1994) J Am Chem Soc 118:7237–7238CrossRefGoogle Scholar
  54. 54.
    Kvols L, Woltering E (2006) Anticancer Drugs 17:601–608CrossRefGoogle Scholar
  55. 55.
    Plosker GL (2015) Drugs 75:1255–1268CrossRefGoogle Scholar
  56. 56.
    Aoyagi Y, Katano K, Suguna H, Prmeau J, Chang LH, Hecht SM (1982) J Am Chem Soc 104:5537–5538CrossRefGoogle Scholar
  57. 57.
    Bonadonna G, De Lena M, Monfardini S, Bartoli C, Bajetta E, Beretta G, Fossati-Bellani F (1972) Eur J Cancer 8:205–215CrossRefGoogle Scholar
  58. 58.
    Koukourakis MI, Maltezos E (2006) Anticancer Drugs 17:2CrossRefGoogle Scholar
  59. 59.
    Gahl WA, Thoene JG, Schneider JA (2002) N Eng J Med 347:111–121CrossRefGoogle Scholar
  60. 60.
    Imada A, Kitano K, Kintaka K et al (1981) Nature 289:590–591CrossRefGoogle Scholar
  61. 61.
    Hilton GF, Das T, Majji S (1996) Indian J Ophthamol 44:131–143Google Scholar
  62. 62.
    Sidharta PN, van Giersbergen PL, Halabi A, Dingemanse J (2011) Eur J Clin Pharmacol 67:977–984CrossRefGoogle Scholar
  63. 63.
    Bang LM, Scott LJ (2003) Drugs 63:2413–2424CrossRefGoogle Scholar
  64. 64.
    Busatto GF, Kerwin RW (1997) J Psychopharmachol 11:3–12CrossRefGoogle Scholar
  65. 65.
    Hulin B, McCarthy PA, Gibbs EM (1996) Curr Pharm Des 2:85–102Google Scholar
  66. 66.
    Strohmaier K, Snyder E, Adamsons I (1998) J Am Optom Assoc 69:441–451Google Scholar
  67. 67.
    Kamen L, Henney HR, Runyan JD (2008) Curr Med Res Opin 24:425–439CrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Chemistry and BiochemistryUniversity of ArizonaTucsonUSA
  2. 2.Department of Pharmacology and ToxicologyUniversity of ArizonaTucsonUSA

Personalised recommendations