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Topics in Current Chemistry

, 374:57 | Cite as

Iron-Catalyzed C–H Functionalization Processes

  • Gianpiero Cera
  • Lutz Ackermann
Review
Part of the following topical collections:
  1. Ni- and Fe-Based Cross-Coupling Reactions

Abstract

Iron-catalyzed C–H activation has recently emerged as an increasingly powerful tool for the step-economical transformation of unreactive C–H bonds. Particularly, the recent development of low-valent iron catalysis has set the stage for novel C–H activation strategies via chelation assistance. The low-cost, natural abundance, and low toxicity of iron prompted its very recent application in organometallic C–H activation catalysis. An overview of the use of iron catalysis in C–H activation processes is summarized herein up to May 2016.

Keywords

Iron C–H activation Chelation assistance Arylation Alkylation Alkenylation Amination 

Abbreviations

AQ

Aminoquinoline

Ar

Aryl

BHT

2,6-Bis(1,1-dimethylethyl)-4-methylphenol

Bu

Butyl

Bn

Benzyl

DABCO

1,4-Diazabicyclo[2.2.2]octane

DCIB

1,2-Dichloroisobutane

DCP

1,2-Dichloropropane

DG

Directing group

dppb

1,4-Bis(diphenylphosphino)butane

dppe

1,2-Bis(diphenylphosphino)ethane

dppen

cis-1,2-Bis(diphenylphosphino)ethylene

dtbpy

4,4′-Di-tert-butyl-2,2′-dipyridyl

E

Electrophile

EDG

Electron-donating group

equiv

Equivalent

EWG

Electron-withdrawing group

FG

Functional group

Hal

Halogen

Het

Heteroatom

Me

Methyl

Mes

Mesityl

PA

Picolinic acid

Ph

Phenyl

Ph-dppen

(Z)-1-Phenyl-1,2-bis(diphenylphosphino)ethylene

Pin

Pinacol

PMP

p-Methoxyphenyl

Pr

Propyl

Q

8-Aminoquinoline

SET

Single electron transfer

TAM

Triazolylaminomethyl

TEMPO

(2,2,6,6-Tetramethypiperidin-1-yl)oxidanyl

TM

Transition metal

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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  1. 1.Institut für Organische und Biomolekulare ChemieGeorg-August-Universität GöttingenGöttingenGermany

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