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Iron-Catalyzed C–H Functionalization Processes

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Abstract

Iron-catalyzed C–H activation has recently emerged as an increasingly powerful tool for the step-economical transformation of unreactive C–H bonds. Particularly, the recent development of low-valent iron catalysis has set the stage for novel C–H activation strategies via chelation assistance. The low-cost, natural abundance, and low toxicity of iron prompted its very recent application in organometallic C–H activation catalysis. An overview of the use of iron catalysis in C–H activation processes is summarized herein up to May 2016.

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Abbreviations

AQ:

Aminoquinoline

Ar:

Aryl

BHT:

2,6-Bis(1,1-dimethylethyl)-4-methylphenol

Bu:

Butyl

Bn:

Benzyl

DABCO:

1,4-Diazabicyclo[2.2.2]octane

DCIB:

1,2-Dichloroisobutane

DCP:

1,2-Dichloropropane

DG:

Directing group

dppb:

1,4-Bis(diphenylphosphino)butane

dppe:

1,2-Bis(diphenylphosphino)ethane

dppen:

cis-1,2-Bis(diphenylphosphino)ethylene

dtbpy:

4,4′-Di-tert-butyl-2,2′-dipyridyl

E:

Electrophile

EDG:

Electron-donating group

equiv:

Equivalent

EWG:

Electron-withdrawing group

FG:

Functional group

Hal:

Halogen

Het:

Heteroatom

Me:

Methyl

Mes:

Mesityl

PA:

Picolinic acid

Ph:

Phenyl

Ph-dppen:

(Z)-1-Phenyl-1,2-bis(diphenylphosphino)ethylene

Pin:

Pinacol

PMP:

p-Methoxyphenyl

Pr:

Propyl

Q:

8-Aminoquinoline

SET:

Single electron transfer

TAM:

Triazolylaminomethyl

TEMPO:

(2,2,6,6-Tetramethypiperidin-1-yl)oxidanyl

TM:

Transition metal

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Authors and Affiliations

  1. Institut für Organische und Biomolekulare Chemie, Georg-August-Universität Göttingen, Tammannstr. 2, 37077, Göttingen, Germany

    Gianpiero Cera & Lutz Ackermann

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  1. Gianpiero Cera
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  2. Lutz Ackermann
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Correspondence to Lutz Ackermann.

Additional information

This article is part of the Topical Collection “Ni- and Fe-Based Cross-Coupling Reactions”; edited by Arkaitz Correa.

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Cera, G., Ackermann, L. Iron-Catalyzed C–H Functionalization Processes. Top Curr Chem (Z) 374, 57 (2016). https://doi.org/10.1007/s41061-016-0059-6

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