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Table 1 Pathogenicity and transmission of three coronavirus (CoV) outbreaks

From: A Review: Does Complement or the Contact System Have a Role in Protection or Pathogenesis of COVID-19?

Virus Outbreak Case fatality rate (%) Pandemic Status
SARS-CoV 2002–2004 9.5 Yes Eradicated from intermediate animal reservoir
MERS-CoV 2012– 34.4 No Continuous circulation in animal reservoir
SARS-CoV-2 (COVID-19) 2019– 3.4a Yes Efforts ongoing
  1. SARS-CoV-2 (COVID-19) is the third coronavirus to emerge in the human population, following SARS-CoV and MERS-CoV. SARS-CoV-2 appears to be less pathogenic in comparison; however, its origin, transmission, and pathogenesis remain largely unknown. (Table newly created, but adapted from Munster et al. [16] and Rajgor et al. [17])
  2. aEstimated by the World Health Organization as of March 3, 2020