Synthesis, Magneto-structural Properties and Colloidal Stability Studies of Ni0.3Zn0.7Fe2O4 Nanoparticles Coated with Pluronic P123 Block Copolymer for Potential Biomedical Applications

Abstract

Spinel Ni0.3Zn0.7Fe2O4 (NZFO) magnetic nanoparticles was prepared by the low temperature auto-combustion method using a glycine fuel-rich composition without any further heat treatment at high temperature. Subsequently, the synthesized MNPs were coated with Pluronic P123 (PP123) after its surface was functionalized with oleic acid (OA). The effect of the coatings on the morphology, structural and magnetic properties of NZFO nanoparticles was studied using powder X-ray diffraction (XRD), Fourier transform infrared, thermogravimetric analysis, field emission scanning electron microscopy (FE-SEM) and vibrating sample magnetometer (VSM). The colloidal behaviour of coated MNPs in physiological saline medium like water or phosphate buffer saline (PBS) was also studied by zeta potential measurements. XRD results showed the formation of cubic spinel crystalline phase with and without OA–PP123 coatings. Also, after OA–PP123 coating, the crystallite size (from Scherrer formula) decreases from 55 to 53 nm. However, an enlargement in the particle size and a reduction in agglomeration were observed from FE-SEM results when the nanoparticles were coated with OA–PP123. VSM measurements showed ferromagnetic behaviour at room temperature before and after coating. The colloidal stability study of the coated sample revealed a considerable high zeta potential value at physiological pH (7.4) highlighting its potential biomedical applications.

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References

  1. Apostolov AT, Apostolova IN, Wesselinova JM (2013) Ferrimagnetic nanoparticles for self-controlled magnetic hyperthermia. Eur Phys J B 86:483

    MathSciNet  Article  Google Scholar 

  2. Baldi G, Lorenzi G, Ravagli C (2009) Hyperthermic effect of magnetic nanoparticles under electromagnetic field. Process Appl Ceram 3(1–2):103–109

    Article  Google Scholar 

  3. Banerjee SS, Chen DH (2007) Magnetic nanoparticles grafted with cyclodextrin for hydrophobic drug delivery. Chem Mater 19:6345–6349

    Article  Google Scholar 

  4. Chiappetta DA, Sosnik A (2007) Poly (ethylene oxide)-poly (propylene oxide) block copolymer micelles as drug delivery agents. Eur J Pharm Biopharm 66:303–317

    Article  Google Scholar 

  5. Colombo M, Carregal-Romero S, Casula MF, Gutierez L, Morales MP, Bohm IB, Heverhagen JT, Prosperi D, Parak WJ (2012) Biological applications of magnetic nanoparticles. Chem Soc Rev 41:4306–4334

    Article  Google Scholar 

  6. Dorniani D, Kura AU, Hussein-Al-Ali SH, Bin Hussein MZ, Fakurazi S, Shaari AH, Ahmad Z (2014) In vitro sustained release study of gallic acid coated with magnetite-PEG and magnetite-PVA for drug delivery system. Sci World J 2014:1–11. https://doi.org/10.1155/2014/416354 (Article ID 416354)

    Google Scholar 

  7. Dutz S, Andra W, Hergt R, Muller R, Oestreich C, Schmidt C, Topfer J, Zeisberger M, Bellemann ME (2007) Influence of dextran coating on the magnetic behaviour of iron oxide nanoparticles. J Magn Magn Mater 311:51–54

    Article  Google Scholar 

  8. Ehi-Eromosele CO, Ita BI, Iweala EEJ, Adalikwu SA, Anawe PAL (2015) Magneto-structural properties of Ni–Zn nanoferrites synthesized by the low-temperature auto-combustion method. Bull Mater Sci 38(5):1465–1472

    Article  Google Scholar 

  9. Gazeau F, Levy M, Wilhelm C (2008) Optimizing magnetic nanoparticle design for nanothermotherapy. Nanomedicine 3:831–844

    Article  Google Scholar 

  10. Gonzales M, Krishnan KM (2007) Phase transfer of highly monodisperse iron oxide nanocrystals with Pluronic F127 for biomedical applications. J Magn Magn Mater 311:59–62

    Article  Google Scholar 

  11. Gul IH, Ahmed W, Maqsood A (2008) Electrical and magnetic characterization of nanocrystalline Ni–Zn ferrite synthesis by co-precipitation route. J Magn Magn Mater 320:270–275

    Article  Google Scholar 

  12. Jadhav SV, Nikam DS, Khot VM, Mali SS, Hong CK, Pawar SH (2015) PVA and PEG functionalised LSMO nanoparticles for magnetic fluid hyperthermia application. Mater Charact 102:209–220

    Article  Google Scholar 

  13. Jordan A, Scholz R, Wust P, Fähling H, Felix R (1999) Magnetic fluid hyperthermia (MFH): cancer treatment with AC magnetic field induced excitation of biocompatible superparamagnetic nanoparticles. J Magn Magn Mater 201:413–419

    Article  Google Scholar 

  14. Kareem SH, Ati AA, Shamsuddin M, Lee SL (2015) Nanostructural, morphological and magnetic studies of PEG/Mn(1−x)Zn(x)Fe2O4 nanoparticles synthesized by co-precipitation. Ceram Int 41:11702–11709

    Article  Google Scholar 

  15. Kashevsky BE, Kashevsky SB, Korenkov VS, Istomin YP, Terpinskaya TI, Ulashchik VS (2015) Magnetic hyperthermia with hard-magnetic nanoparticles. J Magn Magn Mater 380:335–340

    Article  Google Scholar 

  16. Khairy M (2014) Synthesis, characterization, magnetic and electrical properties of polyaniline/NiFe2O4 nanocomposite. Synth Metals 189:34–41

    Article  Google Scholar 

  17. Koh I, Josephson L (2009) Magnetic nanoparticle sensors. Sensors 9:8130–8145

    Article  Google Scholar 

  18. Kolhatkar AG, Jamison AC, Litvinov D, Willson RC, Lee RT (2013) Tuning the magnetic properties of nanoparticles. Int J Mol Sci 14:15977–16009

    Article  Google Scholar 

  19. Kulshrestha P, Gogo M, Bahadur D, Banerjee R (2012) In vitro application of paclitaxel loaded magnetoliposomes for combined chemotherapy and hyperthermia. Colloids Surf B 96:1–7

    Article  Google Scholar 

  20. Kuznetsov AA, Shlyakhtin OA, Brusentsov NA, Kuznetsov OA (2002) Smart mediators for self-controlled inductive heating. Eur Cell Mater 3(Suppl. 2):75–77

    Google Scholar 

  21. Mahdavi M, Namvar F, Ahmad MB, Mohamad R (2013) Green biosynthesis and characterization of magnetic iron oxide (Fe3O4) nanoparticles using seaweed (Sargassum muticum) aqueous extract. Molecules 18:5954–5964

    Article  Google Scholar 

  22. Maier-Hauff K, Uldrich F, Nestler D, Niehoff H, Wust P, Thiesen B, Orawa H, Budach V, Jordan A (2011) Efficacy and safety of intratumoral thermotherapy using magnetic iron-oxide nanoparticles combined with external beam radiotherapy on patients with recurrent glioblastoma multiforme. J Neuro-Oncol 103:317–324

    Article  Google Scholar 

  23. Mamani JB, Costa-Filho AJ, Cornejo DR, Vieirad ED, Gamarra LF (2013) Synthesis and characterization of magnetite nanoparticles coated with lauric acid. Mater Charact 81:28–36

    Article  Google Scholar 

  24. Montagne F, Monval MO, Pichot C, Mozzanega H, Elaissari A (2002) Preparation and characterization of narrow sized (O/W) magnetic emulsion. J Magn Magn Mater 250:302–312

    Article  Google Scholar 

  25. Morales MA, Jain TK, Labhasetwar V, Leslie-Pelecky DL (2005) Magnetic studies of iron oxide nanoparticles coated with oleic acid and Pluronic® block copolymer. J Appl Phys 97:10Q905

    Article  Google Scholar 

  26. Morrison SA, Cahill CL, Carpenter EE, Calvin S, Swaminathan R, McHenry ME, Harris VG (2004) Magnetic and structural properties of nickel zinc ferrite nanoparticles synthesized at room temperature. J Appl Phys 95(11):6392–6395

    Article  Google Scholar 

  27. Nguyen DT, Kyo-Seon K (2014) Functionalization of magnetic nanoparticles for biomedical applications. Korean J Chem Eng 31(8):1289–1305

    Article  Google Scholar 

  28. Prasad AS, Dolia SN (2012) Gd substituted NiCa ferrite/polyvinyl alcohol nanocomposite. J Magn Magn Mater 324:869–872

    Article  Google Scholar 

  29. Rahimi M, Wadajkar A, Subramanian K, Yousef M, Cui WN, Hsieh JT, Nguyen KT (2010) In vitro evaluation of novel polymer-coated magnetic nanoparticles for controlled drug delivery. Nanomed Nanotechnol Biol Med 6:672–680

    Article  Google Scholar 

  30. Rahimi M, Kameli P, Ranjbar M, Salamati H (2013) The Effect of polyvinyl alcohol (PVA) coating on structural, magnetic properties and spin dynamics of Ni0.3Zn0.7Fe2O4 ferrite nanoparticles. J Magn Magn Mater 347:139–145

    Article  Google Scholar 

  31. Sakellari D, Brintakis K, Kostopoulou A, Myrovali E, Simeonidis K, Lappas A, Angelakeris M (2016) Ferrimagnetic nanocrystal assemblies as versatile magnetic particle hyperthermia mediators. Mater Sci Eng C 58:187–193

    Article  Google Scholar 

  32. Shah SA, Asdi MH, Hashmi MU, Umar MF, Awan S (2012) Thermoresponsive copolymer coated MnFe2O4 magnetic nanoparticles for hyperthermia therapy and controlled drug delivery. Mater Chem Phys 137:365–371

    Article  Google Scholar 

  33. Song H, He R, Wang K, Ruan J, Bao C, Li N, Ji J, Cui D (2009) Anti-HIF-1α antibody-conjugated pluronic triblock copolymers Encapsulated with Paclitaxel for tumor targeting therapy. Biomaterials 30(36):6955–6963

    Article  Google Scholar 

  34. Thorat ND, Otari SV, Bohara RA, Yadav HM, Khot VM, Salunkhe AB, Phdatre MR, Prasad AI, Ningthoujam RS, Pawar SH (2014) Structured superparamagnetic nanoparticles for high performance mediator of magnetic fluid hyperthermia: synthesis, colloidal stability and biocompatibility evaluation. Mater Sci Eng C 42:637–646

    Article  Google Scholar 

  35. Uskokovic V, Kosak A, Drofenik M (2006) Preparation of silica-coated lanthanum strontium manganite particles with designable curie point for application in hyperthermia treatments. Int J Appl Ceram Technol 3(2):134–143

    Article  Google Scholar 

  36. Wang J, Pang X, Akinc M, Lin Z (2010) Synthesis and characterization of perovskite PbTiO3 nanoparticles with solution processability. J Mater Chem 20:5945–5949

    Article  Google Scholar 

  37. Widmann G (2001) Interpreting TGA curves. In: Information for users of Mettler Toledo thermal analysis systems. UserCom 1, Switzerland, p 1

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Acknowledgements

This work would not have been possible without the visiting research grant given to Dr. Ehi-Eromosele C.O. by the International Centre for Materials Science, Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore, India.

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Correspondence to Cyril O. Ehi-Eromosele.

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Ehi-Eromosele, C.O., Ita, B.I. & Iweala, E.E.J. Synthesis, Magneto-structural Properties and Colloidal Stability Studies of Ni0.3Zn0.7Fe2O4 Nanoparticles Coated with Pluronic P123 Block Copolymer for Potential Biomedical Applications. Iran J Sci Technol Trans Sci 42, 209–217 (2018). https://doi.org/10.1007/s40995-018-0486-z

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Keywords

  • Magnetic nanoparticles
  • Coating
  • Biomedical application
  • Colloidal stability
  • PP123